Kyle Walding

me: is she sexually active?
them: she’s 82
me: word, is she sexually active?

Patterns of #tuberculosis 🫁
Cr. #devrad

#radiology
#chestrad

@pulmpeeps.bsky.social
@laurengroner.bsky.social
@mmestas.bsky.social

Blood RNA biomarkers and C-reactive protein for triage of adult patients with tuberculosis lymphadenitis and pericarditis in South Africa: a single-centre, prospective, observational, diagnostic accur... Our results suggest RNA biomarkers show better accuracy and clinical utility than C-reactive protein to trigger confirmatory tuberculosis testing in patients with tuberculosis lymphadenitis and tuberc...

Important #TBSky paper @lancetmicrobe.bsky.social by @mnoursad.bsky.social & @innate2adaptive.bsky.social

Diagnosing TB in lymph nodes or pericarditis a challenge

RNA biomarkers better than CRP to trigger confirmatory testing, but still not as good as what WHO specifies for TB triage tests #IDSky

gave an ED provider some very gentle (but important!) clinical feedback today and the person said “we hardly ever get feedback — thank you so much for letting me know!”

this is so gracious! we could all take lessons

if you’re a physician yelling about vaccine committee removals but not about flagrant human rights abuses & genocide, check your priorities

there are no ‘lanes’ when it comes to the preservation of human life and dignity—we have a moral responsibility to speak out and act to protect the vulnerable

hahahaha, you’d have to ask someone smarter than me!

i actually don’t see race as a proxy but a misleading social construct

it is significant work to tease out the actual variables, but it’s worth the work to make actual associations (or recognize the lack of association) rather than invent associations/discordances that perpetuate inequity

right, it’s not always visible bc colorism and racism are separate -isms; also, being from Africa does not identify a clear “race”

educating patients on their risk for conditions is essential, but education about these risks should be based in evidence, not carried on from (however well meaning) racist categorizations

use origin/travel, nutrition/supplementation, behaviors, etc to ID risks—these span “racial” categories

race (not real) has no correlation w country of origin (real)

country of origin (& even smaller regional commonalities like zip code) may have patterns based on cultural characteristics, disease epi, and health access, but even those may not be consistent

the concept of race isn’t necessary to understand that less melanated skin is at higher risk for UV damage—that’s true regardless of someone’s ‘background’

just a quick reminder to the medical community that ~the concept of race has no basis in scientific evidence and should not impact your *medical* decision-making~

race *does have* social implications (which can affect access/quality) bc of the disproportionate global power assigned to ‘whiteness’

i hadn’t! but i did read it and sent it to my bureau director too

Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection - PubMed Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a limited understanding of its clinical pathogenic spectrum of infection and disease. Historically, scientific ...

as i prepare to present data (epi, pathogenesis, presentation, detection, TB control considerations) on subclinical TB tomorrow for the NYC TB bureau, i have relied on this *incredible* review pubmed.ncbi.nlm.nih.gov/30021818/

thank you, @sgschumacher.bsky.social et al!

#TBSky saw this note today: “M africanum in sputum; pt doesn’t meet criteria for NTM disease, stop all therapy”

“MTB complex” includes several closely related human pathogens:
- M tb
- M bovis
- M africanum
- (& M microti, caprae, pinnipedii, orygis, canetti)

all should be treated as ‘TB disease’!

#TBSky: have any clinical TB folks seen hearing loss with BPaLM?

this is not a documented/common adverse effect that i’m aware of, but moxi does have post marketing reports of hearing loss and linezolid could potentially cause it via peripheral neuropathy

thoughts?

my goodness lol 😆

i agree! i do find it useful for identifying references, but i almost never trust the extracted and summarized text because it’s not infrequently misleading or plain wrong! i do use it nearly every day tho to find papers about what i’m trying to understand lol — always read the primary literature!

this!

Job Opportunity at LSHTM: Research Fellow The London School of Hygiene & Tropical Medicine (LSHTM) is a world-leading centre for research and postgraduate education in public and global health. Our mission is to is to improve health and healt...

Are you interested in #TB and have experience in #modelling infectious diseases?

Come join us in the TB Modelling Group at #LSHTM!

We're advertising for a 1 year Research Fellow position, with a closing date of 30 May 2025 👉 jobs.lshtm.ac.uk/vacancy.aspx...

this statement is too broad! there are so many different genres doing great things right now — are you pretty open?

This wasn’t built by an institution or backed by funding.

It was built by clinicians, pharmacists, scientists, & anonymous contributors.

No sponsors. No conflicts. Just evidence.

I’d log in at midnight and see Anonymous Koala editing rows.

That’s public science: open, people-powered, and shared.

okay king! go off

Placebo-Controlled Vaccine RCTs – Living Reference Sheet Placebo-Controlled Vaccine RCTs – Living Reference Sheet Purpose: A one-stop, crowdsourced catalogue of randomized controlled trials (RCTs) in which routine vaccines were tested against an inert or s...

Alright folks, the amazing @jakescottmd.bsky.social has set up a google sheets for you to crowd source published RCTs of vaccines.

Editable sheet (starter trials seeded): bit.ly/3EuYzqI

As data are imported, the website will autoupdate. Have at it!

www.bradspellberg.com/vaccine-rcts

omg real eggs in this economy? ID could never

agreed — it’s a dangerous documentation precedent

in my opinion, *particularly* at a safety net hospital in this current political climate, there is absolutely *no medical necessity* to document citizenship status in a patient’s medical record

if this becomes commonplace, its absence could be taken by some to mean “undocumented”

that’s what makes tb fun 🤗

important learning re calcified granulomas vs LTBI (i get asked this Q a lot) — this is nuanced, but here are some important considerations #TBSky