Brandon Findlay

If you remove the "mab" suffix, most antibody drugs are great names for demons:

Atezolizu
Basilixi
Drozitu
Ozanezu
Porgavixi

@cenmag.bsky.social Pet spa? Really?
It's been ten minutes and my wife is still giggling.

Tripartite Loops Reverse Antibiotic Resistance Abstract. Antibiotic resistance threatens to undo many of the advancements of modern medicine. A slow antibiotic development pipeline makes it impossible t

The story continues here, in a paper that came out a few months back.
academic.oup.com/mbe/article/...

Sequential antibiotic exposure restores antibiotic susceptibility AbstractBackground. The prevalence of antibiotic resistance continues to rise, rendering many valuable antimicrobial drugs ineffective. Pairwise cyclic ant

Bacteria exposed to antibiotics become resistant, that's the core of the #AMR crisis. We figured out how to expose them to antibiotics and evolve susceptibility instead. @farhanrc.bsky.social shows how, in our latest paper.
academic.oup.com/jac/advance-...

YouTube video by Concordia University School of Health Meet The Researcher: Brandon Findlay, Chemistry & Biochemistry, Antimicrobial Resistance Researcher

We’re proud to showcase the work of Brandon Findlay, Associate Professor in #Chemistry & #Biochemistry at @concordia.ca whose lab is tackling one of today’s most pressing #GlobalHealth challenges: #AntimicrobialResistance.

#HealthResearch #AntibioticResistance

www.youtube.com/watch?v=MGxV...

The Findlay lab turned 10 years old today! What an incredible journey it's been.

Forecasting the Fallout from AMR: Economic Impacts of Antimicrobial Resistance in Humans Antimicrobial resistance (AMR) is a growing global health crisis that threatens to undo decades of progress in medicine. This tool allows you to explore the potential impact of different interventions...

Pretty cool tool to visualize the cost of #AMR

Large scale laboratory evolution uncovers clinically relevant collateral antibiotic sensitivity The increasing prevalence of antibiotic resistance is a critical challenge, necessitating the development of strategies to mitigate the evolution of r…

New paper from the lab!
Evolving bacteria in the lab is a great way to understand #AMR. But, does it matter what evolution platform you use? Yes.

@farhanrc.bsky.social showed different platforms select different evolutionary paths. Read more at IJAA:
www.sciencedirect.com/science/arti...
#microsky

Metabolic and genomic adaptations of Salmonella Typhimurium grown on itaconate Jacob Pierscianowski, Suzana Diaconescu-Grabari, Farhan R. Chowdhury, Andreanne Lupien, Brandon L. Findlay, Karine Auclair

🚨NEW PREPRINT ALERT:

In this paper, Jacob and Suzana from the Auclair lab investigate how Salmonella Typhimurium adapts to growing on itaconate, with detailed metabolic and genomic studies.

Many thanks to our collaborators at McGill and Concordia! (Details below) #chemsky

doi.org/10.1101/2025...

Tripartite loops reverse antibiotic resistance Abstract. Antibiotic resistance threatens to undo many of the advancements of modern medicine. A slow antibiotic development pipeline makes it impossible t

The latest work from my lab is out in @molbioevol.bsky.social! @farhanrc.bsky.social evolved bacteria right into evolutionary traps, reverting antibiotic-resistant strains back into sensitive ones. #microsky academic.oup.com/mbe/advance-...

History. The classic alkaloids like morphine and caffeine predate the discovery of DNA and enzymes by a hundred years.

Toxin-antitoxin systems are weird, but seem pretty effective. So where are the plasmids with 20+ toxin/antitoxin pairs? The logic that makes one pair adaptive should be true for 2 pairs, 3 pairs, n+1 pairs...
#microsky

Congrats!

This seems like a fitting first post. My lab has just published a paper on the evolution of resistance to Octyl-tridecaptin A1!

This antibiotic is tough to evolve resistance against. To crack it we had to optimize SAGE, our lab evolution system.
www.sciencedirect.com/science/arti...

#AMR #microsky