Farhan RC

Sequential antibiotic exposure restores antibiotic susceptibility AbstractBackground. The prevalence of antibiotic resistance continues to rise, rendering many valuable antimicrobial drugs ineffective. Pairwise cyclic ant

When bacteria evolve resistance to one antibiotic, they can become more vulnerable to another, a phenomenon called ‘hypersensitivity.’ We find antibiotics that leverage this, and emphasize the importance of the 'directionality' of hypersensitivities for improved therapies.

#AMR #microsky

09.10.2025 14:19 — 👍 2    🔁 0    💬 0    📌 0

Why antibiotics are like fossil fuels They helped create the modern world but are dangerously overused. How can we harness them sustainably?

"It’s as if every time you took a painkiller for your headache, you increased the chance that somebody else might have to undergo an operation without anaesthetic."

"It’s hard to imagine a more perfect anti-capitalist commodity than a product whose value depletes every time you use it."

#AMR

17.08.2025 16:58 — 👍 2    🔁 0    💬 0    📌 0

Forecasting the Fallout from AMR: Economic Impacts of Antimicrobial Resistance in Humans Antimicrobial resistance (AMR) is a growing global health crisis that threatens to undo decades of progress in medicine. This tool allows you to explore the potential impact of different interventions...

Pretty cool tool to visualize the cost of #AMR

01.08.2025 03:51 — 👍 1    🔁 1    💬 0    📌 0

Large scale experimental evolution can help identify trade-offs associated with antibiotic resistance that can have clinical relevance. We use multiple platforms to discover one such trade-off, and describe its mechanism in our report in IJAA.

03.07.2025 19:17 — 👍 2    🔁 0    💬 0    📌 0

Metabolic and genomic adaptations of Salmonella Typhimurium grown on itaconate Jacob Pierscianowski, Suzana Diaconescu-Grabari, Farhan R. Chowdhury, Andreanne Lupien, Brandon L. Findlay, Karine Auclair

🚨NEW PREPRINT ALERT:

In this paper, Jacob and Suzana from the Auclair lab investigate how Salmonella Typhimurium adapts to growing on itaconate, with detailed metabolic and genomic studies.

Many thanks to our collaborators at McGill and Concordia! (Details below) #chemsky

doi.org/10.1101/2025...

21.06.2025 11:57 — 👍 3    🔁 3    💬 1    📌 0

Compensatory evolution is a menace in the clinic, enabling maintenance of costly resistance determinants. We've built 3-drug evolutionary traps where bacteria compensate for the costs of resistance by reverting back to sensitivity!
#microsky

06.06.2025 21:13 — 👍 1    🔁 0    💬 0    📌 0

Photodynamic inactivation and its effects on the heterogeneity of bacterial resistance - Scientific Reports Scientific Reports - Photodynamic inactivation and its effects on the heterogeneity of bacterial resistance

Online version missing whole figures, and pdf missing half of the figure captions. Scientific Reports 👌

28.02.2025 19:06 — 👍 0    🔁 0    💬 0    📌 0

Mutational signature analysis predicts bacterial hypermutation and multidrug resistance - Nature Communications Mutational signature analysis of Pseudomonas aeruginosa identifies hypermutator clinical strains and prognostically predicts multidrug resistance acquisiton, potentially serving as a tool to guide eff...

Mutations in MMR (mismatch repair) genes do not predict an MMR phenotype, but a "trinucleotide mutational signature" does.

28.02.2025 18:52 — 👍 0    🔁 0    💬 0    📌 0

De novo evolution of antibiotic resistance to Oct-TriA1 The rise of antimicrobial resistance as a global health concern has led to a strong interest in compounds able to inhibit the growth of bacteria witho…

The idea of "evolution proof" antibiotics is cool, but it will probably remain an idea. We break an evolution proof antibiotic Tridecaptin in this paper. Improved lab evolution platforms will be crucial to help predict resistance.

#AMR #antibiotic #resistance

25.01.2025 23:14 — 👍 2    🔁 0    💬 0    📌 0