Theory of Living Matter Group

Poster with a picture of the speaker, Pablo Saez, advertising his talk: Decision Making during cell migrations. Abstract: Moving cells navigate inside living tissues often encountering obstacles and junctions, where their path branches into alternative directions of migration. This is the case of cells moving on top or within blood vessels, which often bifurcate into branches. Cells have diverse migratory strategies that differentially rely on the adhesion to the substrate. Cells that undergo mesenchymal migration are highly dependent on the adhesion to the substrate, and when facing bifurcations are forced to coordinate the adhesion and detachment of the competing branches. Recent studies showed how the decision is made -to keep or retract a branch and choose a new direction- when there is bias: open versus dead-end, differences in pressure, presence/absence of a chemoattractant. However, much less is know about how cells decide a new direction when the decision is unbiased. Similarly, it is poorly understood how migrating cells coordinate membrane dynamics during branching to maintain a good trade-off between microenvironmental exploration and migratory efficiency. Here, we use in vitro live-cell imaging using different levels of complexity, and advanced image analysis to analyze the response of migrating cells when facing symmetric junctions, and extreme branching when cells simultaneously face several bifurcations. We found that actin and membrane dynamics play a key role to choose a new direction path in both cases i) when cells face a single junction (Ron et al. 2024), and ii) when cells exhibit high levels of branching because they face several junctions at the same time (Liu et al.). In addition, we found that migrating immune cells have a fine tune regulation of branching in order to coordinate surveillance and migration. These results shed light on the mechanisms by which cells resolve unbiased junctions and branching during cell migration.

🚨 TLM Online Seminar Series - 08.10.25 | 16:00 UK
Pablo Sáez: "Decision-making during cell migration"

Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...

@cammorphoseries.bsky.social @pflenne.bsky.social @pjsaez.bsky.social

🚨New academic year calls for a new lineup of speakers. ✍️Sign up to our mailing list to hear these wonderful array of speakers this term. Please reshare among your networks 📩 lists.cam.ac.uk/sympa/subscr...

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Opportunity for senior lecturer (associate professor) in School of Chemistry at University of Bristol (UK) ref: ACAD108220 | closing: 30-Sep-2025 #UKChemJobs #ChemJobs #chemsky 🧪
www.bristol.ac.uk/jobs/find/de...

Interested in a sabbatical in Lyon? The Collegium de Lyon provides accommodation and attractive interdisciplinary environment for 1 or 2 semesters. Open to all disciplines. You can be affiliated with any local department/lab. Apply now for 2026-27. collegium.universite-lyon.fr/2026-2027-un...

Excited to share my postdoc work from the Eggeling lab in Jena (@leibnizipht.bsky.social, #FSUJena, #KTHuniversity) on bringing smart microscopy to super-resolution MINFLUX: event-triggered MINFLUX microscopy.

Have you signed up to speak at our seminar series the upcoming academic year? Sign up is open till end of the month. Share among your networks for this amazing opportunity to showcase your research 📝📩

If you are in Cambridge do consider joining our committee by emailing us

Early Career Speaking List - Theory of Living Matter Sign up to be considered as an Early Career Speaker at our upcoming events! Selected participants will have the opportunity to present their work and network with professionals in the field. Importa...

Thank you to everyone who has supported TLM talks. We will be back in Ocotber with some new exciting talks. We have plans to incorporate short talks by students and postdocs, fill out this form to express your interest forms.gle/34vMwQNVGnvm....
Have a nice summer 🌅

📢Happening today at 4pm UK time!

🚨 Join us tomorrow for this really exciting talk on the interplay between morphogen signalling and tissue organization! 🚨

🚨Next week, Wed 09/07 | 16:00 UK - Online Seminar🚨

"Feedback between morphogen signalling and tissue architecture drives robust developmental patterning" by Dr Zena Hadjivasiliou.

To attend online please register to our 📧 for the zoom link: lists.cam.ac.uk/sympa/subscr...

📢Happening today in a few hours! If you've not received the link do DM📩 us for the zoom link

🚨Join us tomorrow for this exciting talk on theory and experiment. 🚨 Please RT and follow us📝 for more such talks

🚨Our next seminar on, Wed 25/06 | 16:00 UK - online by Karen Kasza from @Columbia. Join us online🚨📝for the zoom link: lists.cam.ac.uk/sympa/subscr...

🚨Our next seminar on, Wed 25/06 | 16:00 UK - online by Karen Kasza from @Columbia. Join us online🚨📝for the zoom link: lists.cam.ac.uk/sympa/subscr...

🚨Join us online for this talk hybrid format at 14:30 BST. Sign up to our mailing list for zoom links or DM us. For those in Cambridge join us in person at the Sainsbury Laboratory in collaboration with @cammorphoseries.bsky.social 🐁

We are excited to co-host Chii Jou Chan’s talk with @tlmcambridge.bsky.social‬ next Monday at 14:30, which will be the last talk of the term. Hope to see many of you there!

🚨Our next seminar on, Mon 16/05 | 14:30 UK - Hybrid Seminar in collaboration with @cammorphoseries.bsky.social at @slcuplants.bsky.social we have Chii Jou Chan from @mbisg.bsky.social Come join us in person if you are in Cambridge🚨📝for the zoom link: lists.cam.ac.uk/sympa/subscr...

🚨 TLM Online Seminar Series - 28.05.2025 | 16:00 UK
Xavier Salvatella: "Sequence-Encoded Determinants of Condensate Kinetic Stability"

Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...

🚨TLM SEMINAR TOMORROW: Subscribe now to receive the link before the talk!
“Sequence-Encoded Determinants of Condensate Kinetic Stability” - Dr. Xavier Salvatella from @irbbarcelona.org
Mailing list:
lists.cam.ac.uk/sympa/subscr...

🚨 TLM Online Seminar Series - 28.05.2025 | 16:00 UK
Xavier Salvatella: "Sequence-Encoded Determinants of Condensate Kinetic Stability"

Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...

🚨Online Seminar - TOMORROW! 14.05.25 | 16:00 UK

Alessandra Villa & Berk Hess (KTH) : "Enhance simulation sampling using GROMACS"

Please repost & to attend online please register to our 📧for the zoom link:

lists.cam.ac.uk/sympa/subscr...

🚨 TLM Cambridge Online Seminar - 14.05.25 | 16:00 UK
Alessandra Villa & Berk Hess (KTH) : "Enhance simulation sampling using GROMACS"

Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...

🚨 Today, let’s explore the emergent order together with Prof Yilin Wu!

Join us online tomorrow!

🚨Next week, Wed 30/04 | 16:00 UK - Online Seminar🚨

"Learning the emergent order of living matter from bacteria" by Prof Yilin Wu from The Chinese University of Hong Kong.

To attend online please register to our 📧 for the zoom link: lists.cam.ac.uk/sympa/subscr...

@xsalvatella1.bsky.social @zhvas.bsky.social