Sebastian Deorowicz

FAMSA2 enables accurate multiple sequence alignment at protein-universe scale We introduce FAMSA2, an algorithm that produces high-accuracy multiple protein sequence alignments with unprecedented speed. Across structural, phylogenetic, and functional benchmarks, FAMSA2 matches ...

Interested in a tool that aligns millions of proteins in minutes with quality similar to or better than the state-of-the-art utilities? Please take a look at our FAMSA2 paper: www.biorxiv.org/content/10.1...
and GH repo: github.com/refresh-bio/...

Vclust generates fast and accurate estimation of average nucleotide identity (ANI) for viral genomes, scaling clustering to millions of genomes. @sdeorowicz.bsky.social @bedutilh.bsky.social @prozwalak.bsky.social
@uni-jena.de @microverse.bsky.social

www.nature.com/articles/s41...

Ultrafast and accurate sequence alignment and clustering of viral genomes - Nature Methods Vclust generates fast and accurate estimation of average nucleotide identity for viral genomes, scaling clustering to millions of genomes.

Vclust (the ultra-fast, high-accuracy tool for viral genome comparison & clustering) is now published:
www.nature.com/articles/s41...
Great collaboration with A.Zielezinki, UAM guys and @bedutilh.bsky.social

Scalable and unsupervised discovery from raw sequencing reads using SPLASH2 - Nature Biotechnology SPLASH2 speeds up analysis of sequence variation in massive datasets.

Recently, our SPLASH paper (www.nature.com/articles/s41...) was published in NatBiotech. Now, we release its extended version, sc-SPLASH (www.biorxiv.org/content/10.1...), which allows reference-free analysis of single-cell data. It was a great experience to work with our collaborators on that!

GitHub - refresh-bio/agc: Assembled Genomes Compressor Assembled Genomes Compressor. Contribute to refresh-bio/agc development by creating an account on GitHub.

First post here. :-) AGC 3.2 (assembled genome compressor) has been released. Better speed, better ratio (at least for bacteria genomes), optional low-memory decompression.
github.com/refresh-bio/...