Jamie Smith

Systems analysis reveals alternate metabolic states adopted by Mycobacterium tuberculosis across species Mycobacterium tuberculosis (Mtb) persists within macrophages, yet how different host species shape bacterial state remains poorly understood. Here, we directly compared the intracellular transcriptome...

Excited to share our lab's newest preprint (strap in if you're excited about metabolism, species differences, or Mtb gene expression): www.biorxiv.org/content/10.1...

A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics - Nature Microbiology The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.

Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...

The summarised schedule of Black in Micro Week 2025, October 14-16. All times are in Eastern Standard Time. Mon 14: Pathways for Change. Welcome and Keynote Address 12pm. Marian Johnson-Thompson, PhD. Panel Discussion: Finding Black Spaces in STEM, 1:15-2:15 PM. Weds 15, Careers & Research: ECR Symposium 9-12 PM. Panel discussion: Navigating Careers in Microbiology 2-3 PM. Thurs 16, Community: Panel Discussion - Empowering Your Science 12-1:15 PM. Workshop: Science in Action

Friendly reminder: 🎉 Pre-register today & get ready to join our FREE online celebration. Everyone is welcome. To keep #BlackInMicro alive Donate: tinyurl.com/GiveBiM and Register to attend: linktr.ee/BlackInMicro (see links in bio) #BiMWeek2025

🗓️ Check it out! The full agenda for Black In Microbiology Week 2025 is live. Get all the details here: tinyurl.com/BIMW25 and Pre-register to secure your spot: linktr.ee/BlackInMicro. To help keep #BlackInMicro alive, Donate here: tinyurl.com/GiveBiM (all links in bio)

#MicroSky 🧪🧫

Yersinia pseudotuberculosis growth arrest during type-III secretion system expression is associated with altered ribosomal protein expression and decreased gentamicin susceptibility Author summary Slow-growing bacterial cells generally have reduced antibiotic susceptibility, rendering them difficult to eliminate during antibiotic treatment. However, for many key virulence factors...

Research from @johnshopkinsmmi.bsky.social & @johnshopkinssph.bsky.social Lab of Kimberly M. Davis @davislabjhu.bsky.social featured in @plos.org Pathogens

Davis Lab paper 'Yersinia pseudotuberculosis growth arrest during type-III secretion system ...' ⬇️ ⬇️ ⬇️

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journals.plos.org/plospathogen...

Yersinia pseudotuberculosis growth arrest during type-III secretion system expression is associated with altered ribosomal protein expression and decreased gentamicin susceptibility Author summary Slow-growing bacterial cells generally have reduced antibiotic susceptibility, rendering them difficult to eliminate during antibiotic treatment. However, for many key virulence factors...

Microbiologist & Associate Professor Kim Davis @davislabjhu.bsky.social & her lab team investigate gene expression changes associated with bacterial growth to find markers that predict bacterial survival after antibiotic treatment.

DAVIS LAB
bit.ly/45ZMgxj

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journals.plos.org/plospathogen...

Celebrated Kate’s PhD thesis defense today! Huge congrats to the new Dr. Cotten and fantastic job on your seminar and defense!! 😀

Excited to post our first S. aureus preprint on biorxiv! Big congrats to co-first authors, postdocs @anjali20anil.bsky.social and Rezia Braza, and really enjoyed the collaboration with @torreslab.bsky.social !

Big congrats to the new Dr. Cotten @katecotten.bsky.social on the manuscript submission! Preprint is now available on biorxiv, and links a tRNA modification to specific reductions in ribosomal gene expression and antibiotic tolerance. Check it out! 😀

Congratulations Dr. Cotten!! 🥳 @katecotten.bsky.social @davislabjhu.bsky.social

🎉 Congratulations to @johnshopkinssph.bsky.social & @johnshopkinsmmi.bsky.social PhD graduate Kate Cotten, PhD, who successfully defended her PhD thesis!

Way to go, Kate!

Read more about Kate & other MMI PhD students here
publichealth.jhu.edu/departments/...

#standupforscience2025 DC! Great to feel such a strong sense of community after so many weeks of uncertainty

Congratulations! 🎉🎉

Flyer with scan code to nominate a Black Scientist

Nominations are open for the Index of Inspiring Black Scientists! We're building a global resource to celebrate and connect inspiring Black scholars in STEM at all career stages. Nominate someone today! Details: forms.gle/7nq5s2xBENUF...

#InspiringBlackScientists

Happy holidays from the Davis lab!! Had a holiday breakfast this morning with our annual white elephant gift exchange! 🥳🎁 Very thankful to work with this great group of scientists!! 😀

Transgender Day of Remembrance (TDOR) is an annual observance on November 20 that honors the memory of the transgender people whose lives were lost in acts of anti-transgender violence. glaad.org/tdor-memoriam/

Antibiotic-recalcitrant Salmonella during infection - Nature Reviews Microbiology In this Review, Giorgio and Helaine provide an overview of the physiology of antibiotic-recalcitrant Salmonella enterica during infection, discuss recent insights into the clinical implications of ant...

New Salmonella Persister cells Review is just out❗️

Rachel Giorgio & Sophie Helaine overview the physiology & clinical implications of antibiotic-recalcitrant Salmonella during infection

- highlighting important knowledge gaps that need to be addressed…

www.nature.com/articles/s41...

Believe it or not, GRC has told me we need more registered applicants or this meeting might not survive! Please don't let that happen if you can afford to attend 🙏

November 18 is the International Day of LGBQTIA+ People in STEM! Today more than ever we want to stress the importance of communities, building connections, and raising each other up. Let's keep leaving our mark for the betterment of us all! 🏳️‍⚧️🏳️‍🌈 #QueerinSTEM

prideinstem.org/lgbtstemday/

Today is International Day of LGBTQIA+ People in STEM! We are marking this occasion with our first ever Pride in Microbiology Research Symposium and have a lineup of incredible speakers!

#QueerinSTEM

It's still not too late to register: forms.gle/cE8n7F1688Ns...

#MicroSky 🧪🧫🦠

Excited to see many in the bacterial pathogenesis community joining here in the last few weeks, so here's a Starter Pack to help make connections. Reply/DM to be added to this or future Packs. #Microsky go.bsky.app/VH64BaY

Transgender Awareness Week | GLAAD Each year between November 13 – 19, people and organizations around the country participate in Transgender Awareness Week to help increase understanding about transgender people and the issues…

It's Transgender Awareness Week (November 13th - November 19th): A time to reflect and learn about the issues that transgender people face, and how we can better support our trans friends and colleagues.

You can learn more here:

Starter packs BIOLOGY Ecology Macroecology https://go.bsky.app/GBn9pNZ Global ecology https://go.bsky.app/V6tN4cv Trait based ecology and evolution https://go.bsky.app/PThMXeX Invasion biology https://go.b...

hey everyone! i made a list of some useful starter packs (primarily biology/earth sciences with a few bonus things thrown in) to share with friends who have joined bsky in the last week and thought it may be useful for some people here too! 🌍🧪 #SciSky #BioSky docs.google.com/document/d/1...

Welcome refugees from X! Follow microbiologists and more in the @binningsingletons.com and Friends Starter Pack!

go.bsky.app/H5k2p2g

go.bsky.app/L3L2iFz

MAMPM February 2-4, 2025 Wintergreen Resort, Virginia

Calling all microbiologists! Registration is open for the Mid-Atlantic Microbial Pathogenesis Meeting, February 2-4, 2025.! Abstract deadline is 12/8/2024, but don't wait, filling fast. Check it out at mampm.org.

MAMPM February 2-4, 2025 Wintergreen Resort, Virginia

Exciting keynote line up at MAMPM.org: Sean Crosson, Johnna Frierson, @copperbae.bsky.social, Carol Kumamoto, @stallingslab.bsky.social! Hope to see you in Virginia in February!

Parsa and Jamie, our PhD students from Seattle, lost a bet…😂 #goblue