Congrats @mcdonnelllab.bsky.social on this amazing paper. Resharing in case for those who haven’t had the chance to read it yet!

26.06.2025 20:06 — 👍 6    🔁 1    💬 0    📌 0

Congratulations to anyone that managed to get their hands on an IFNα keyring at #PReS2025!
Credit to the @mcdonnelllab.bsky.social 3D printing facility for helping with this, it went down a treat!
Thank you to those that sent over pictures of these in the session audiences too!

18.09.2025 13:50 — 👍 1    🔁 1    💬 0    📌 0

#MedSky @mcdonnelllab.bsky.social

14.04.2025 15:17 — 👍 1    🔁 1    💬 0    📌 0

💉 Antiphospholipid Syndrome (#APS) is an autoimmune disorder that requires our urgent attention.

🔬 Thanks to your support, we've been able to fund researchers like Dr Thomas McDonnell. His ground-breaking work is advancing our understanding of APS, paving the way for better treatments.

14.04.2025 14:47 — 👍 6    🔁 4    💬 1    📌 1

Great talks at London Proteomics Day, including our own research on novel cardiovascular biomarkers in childhood lupus beautifully presented by Dr. Junjie Peng @arrdept-ucldom.bsky.social

08.04.2025 20:20 — 👍 4    🔁 3    💬 0    📌 0

And to top it off, it seems to bind to those antibodies in APS differently after being cleaved by plasmin. We're really proud to have been so comprehensive in the study, but there is still so much to understand about this molecule!

07.04.2025 13:59 — 👍 3    🔁 0    💬 0    📌 0

B2GPI also behaves very differently after being cleaved by plasmin, a lot of literature exists showing the changes but we dont really have a specific reason why it changes its behaviour. This paper suggests its because it forms a new physical structure, it looks different so it behaves differently

07.04.2025 13:59 — 👍 2    🔁 0    💬 1    📌 0

Why is this important? Well B2GPI is the main autoantigen for antiphospholipid syndrome (APS). Patients with APS attack B2GPI, that changes its function and makes clots happen. The clots are eventually broken down by plasmin in a normal fashion. So we know plasmin and B2GPI are close to eachother

07.04.2025 13:59 — 👍 4    🔁 1    💬 1    📌 0

Plasmin cleavage of β2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies β2-Glycoprotein I (β2GPI) is the main autoantigenic target of antiphospholipid syndrome, with antibodies leading to clinical manifestations. There are 2 known structural isomers of β2GPI: a J shape an...

Happy to share our newest paper in JTH, revealing novel structures of B2GPI in the presence of plasmin which alter antibody binding

www.jthjournal.org/article/S153...

07.04.2025 13:51 — 👍 3    🔁 2    💬 3    📌 1

Congrats Junjie! Great achievement and wonderful guy!

07.04.2025 13:44 — 👍 1    🔁 0    💬 0    📌 0

Congratulations to Dr. Junjie Peng who has just been awarded his PhD for work on multi-omic signatures in juvenile lupus! Junjie is also the recipient of the Best Oral Presentation Award at Versus Arthritis Fellows meeting. adolescent-rheumatology.uk/news-awards/

07.04.2025 10:15 — 👍 12    🔁 3    💬 1    📌 0

Great couple of days for @arrdept-ucldom.bsky.social at the Versus Arthritis fellows meeting 2025
@georgearobinson.bsky.social

13.03.2025 12:05 — 👍 7    🔁 2    💬 0    📌 1

Incredibly interesting data!

02.04.2025 19:19 — 👍 3    🔁 0    💬 0    📌 0

Great job George and Heather! Cant wait to hear all about it!

02.04.2025 19:07 — 👍 1    🔁 0    💬 1    📌 0

Proud moment last week with first major conference oral presentation abstract accepted for PhD student Heather Cross #EULAR2025! Also my first PI/student double bill! Bring on Barcelona!
@arrdept-ucldom.bsky.social

31.03.2025 10:15 — 👍 7    🔁 3    💬 1    📌 2