Lizzy Rosser

Weekly recap in ACR Journals - Arthritis & Rheumatology cover

New studies posted this week in Arthritis & Rheumatology:

Adalimumab ± MTX as first-line therapy for childhood-onset chronic uveitis
doi.org/10.1002/art....

Bisphosphonates & PPI/H2RA coprescriptions in polymyalgia rheumatica
doi.org/10.1002/art....

How age, sex and genetics shape our antibodies Age, biological sex, and human genetic factors influence the production of antibodies during the immune response. A team of scientists from the Institut Pasteur, the CNRS and the Collège de France hav...

How age, sex and genetics shape our antibodies ?

A team of scientists from the Institut Pasteur, the @cnrs.fr and the @college-de-france.fr have shown that these factors determine not only the quantity of antibodies produced but also the specific viral regions they target. ↘️

Check out @madhvimenon.bsky.social 🌟 new paper on refractory myasthenia gravis - such an important unmet need. Congratulations Madhvi and the whole team!

@biorxivpreprint.bsky.social Hyperfunctional, gzmK-biased, glucose-responsive CD20+ cytotoxic T lymphocytes may contribute to the chronic low-grade inflammation characteristic of type 2 diabetes
www.biorxiv.org/content/10.6...

Swim 8km in March 2026 GOSH Charity

It’s my favourite day of the year - @greatormondst.bsky.social birthday! My group is incredibly lucky to collaborate in a small way with this incredible hospital, its staff, patients and their families. Anyone fancy signing up for a 8K swim?

www.gosh.org/get-involved...

Call for action on understudied lung cancer in never-smokers Lung cancer patients who have never smoked make up a significant and growing share of global lung cancer cases, yet remain an understudied group, according to a new review written by UCL researchers.

Lung cancer in never-smokers represents a growing share of lung cancer cases and is often diagnosed later, leading to worse outcomes. A new review led by Dr Deborah Caswell @uclmedsci.bsky.social calls for more funding to improve screening, detection and prevention of this form of the disease

🧬 Have you submitted your abstract for #UKimmunomet26? The deadline is approaching in 3 weeks!

Join the UK’s leading immunometabolism meeting in NCL for cutting edge research, international speakers & sessions for ECRs.

Find out more & register 🔗 https://bit.ly/493uE45

Our second annual meeting - please save the date and distribute

Thank you…!!!

Happy Women and Girls in Science Day! To honour the occasion.... we're launching our website - rosserlab.com. Have a look around, it's designed for young people who participate in our studies, their families and other scientists. HUGE thanks
@hlpeks.bsky.social for designing it 🤠

@nihr.bsky.social is looking for a new public committee member. No scientific or academic background needed. Opportunity for public/patients to shape research, deepen their knowledge, develop new skills and connections. #PPI #involvement
www.nihr.ac.uk/get-involved...

Please share 🔄

Targeted deep sequencing identifies mosaicism in patients with immune dysregulation @jacionline.bsky.social
www.sciencedirect.com/science/arti... @washumedicine.bsky.social @macattacklab.bsky.social

XCR1+ Conventional type 1 dendritic cells exacerbate the inflammation in osteogenic arthritis through IL-17A+CD8+ T cells. Graphical abstract created using BioRender

Single-cell RNA-seq study of blood and synovial fluid from patients with newly diagnosed oligoarthritis and enthesitis-related arthritis provides evidence linking HLA-B27, conventional type 1 dendritic cells, and CD8⁺ T cells within a unified pathogenic axis

A&R
doi.org/10.1002/art....

Thanks for the highlight!

Synovial Fluid Cell Counts and the Degree of Synovial Tissue Lymphocytic Inflammation in Patients with Rheumatoid Arthritis. Graphical abstract created using BioRender

Analysis of synovial fluid and tissue samples from rheumatoid arthritis patients undergoing knee arthroplasty showed synovial fluid features reflected findings in the synovial tissue, and could differentiate high & low lymphocytic synovial inflammation

ACR Open Rheumatology
doi.org/10.1002/acr2...

Integrated single-cell analyses of affinity-tested B cells enable the identification of a gene signature to predict antibody affinity Chirichella and colleagues integrated single-cell transcriptomics, BCR sequences, and affinity measurements to identify High Signature, a gene expression signature predictive of sub-nanomolar antibodi...

Integrated single-cell analyses of affinity-tested B cells enable the identification of a gene signature to predict antibody affinity @astrazeneca.bsky.social @angelettilab.bsky.social
www.cell.com/cell-systems...

Let’s go 💪 beyond excited to be part of this new initiative led by @emmaschambers.bsky.social

Our paper retweeted by the @labwaggoner.bsky.social! Maybe we’ve made it to the big time!

🔬 New research from @uclmedsci.bsky.social, @moorfields.bsky.social & @greatormondst.bsky.social is changing how we understand a sight-threatening condition in children with arthritis - bringing us closer to protecting children’s sight. 👁️

👉 Read the full story on our website:
bit.ly/49SfuQW

Altered B cell activation contributes to the immunopathogenesis of childhood arthritis-associated uveitis - Nature Communications Juvenile idiopathic arthritis (JIA) associated uveitis can cause vision loss in children, but mechanisms remain unclear. The authors here identify elevated CD19+IgD-CD27- double negative type 1 B cell...

Very proud that our investigating uveitis pathogenesis in young people living with arthritis is out today @natcomms.nature.com. A real team science effort made possible by collaborations across hospital & researchers with support of patients. Check it out 👇
www.nature.com/articles/s41...

"Ever wondered what happens if you remove Tfh cells from established germinal centres?" A great research question from former #ListerFellow @linterman.bsky.social.

🔽 Paper in Science Immunology www.science.org/doi/10.1126/...
⏬ Click and read Michelle's full thread

Congrats to Michelle and team 👏

The Royal Society Rosalind Franklin Award is made to support projects that promote women in STEM. Find out more and make your nomination now: #RSMedals #WomenInSTEM https://royalsociety.org/medals-and-prizes/rosalind-franklin-award/

head and shoulder photograph of Dr Nicola Whiffin with a broad smile and looking directly at camera.

Today we celebrate #ListerFellow @nickywhiffin.bsky.social 🤩She's on The Sunday Times Alternative Honours List 2025 for her role in discovering ReNU syndrome and the non-coding variants behind the disorder 👏
Read this fab story of discovery and rapid uptake👉 lister-institute.org.uk/renu-ed-hope...

🤩

Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes. From @hlpeks.bsky.social, @emmaschambers.bsky.social, @bcellsrosser.bsky.social, Ciurtin et al. 👉 rupress.org/jem/article/...

📘 In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...

Had a great time back at the BSI presenting the first of my post-doc work!

Registrations are now open for 'Fuelling the immune response', the 4th UK immunometabolism meeting, led by the BSI Immunometabolism Affinity Group.

Join us in Newcastle on 16 and 17 April 2026 for cutting edge immune metabolism research #UKimmunomet26

Register here: https://bit.ly/493uE45

Delighted out study was to be included on this list @jem.org have a scroll through and check it out (sex differences in class-switched memory B cells) - hubs.la/Q03YbLjR0

A new UK-led research group, including @ucl.ac.uk's Prof Lucy Wedderburn (@uclchildhealth.bsky.social), Prof Coziana Ciurtin & Dr Polly Livermore, aims to improve arthritis care by defining for the first time what remission truly means. Funded by £3m from Arthritis UK www.ucl.ac.uk/news/2025/de...

Great teaser for forthcoming publication from former #ListerFellow @linterman.bsky.social ⏬

And what a lovely pic to sum up science:
🤝close friendship and collaboration
🧠shared curiosity
🎨fresh data (what a gorgeous backdrop image😍)
🔎new insights and understanding