Sigrid Skånland's Avatar

Sigrid Skånland

@sigridskanland.bsky.social

Project group leader and researcher at Institute for Cancer Research, Oslo University Hospital. Developing functional precision medicine for hematologic malignancies. Sometimes photographer. https://www.ous-research.no/skanland

43 Followers  |  59 Following  |  2 Posts  |  Joined: 16.01.2025  |  1.8185

Latest posts by sigridskanland.bsky.social on Bluesky

Protein profiles predict treatment responses to the PI3K inhibitor umbralisib in patients with chronic lymphocytic leukemia Abstract. Purpose: The management of chronic lymphocytic leukemia (CLL) has significantly improved with targeted therapies. However, many patients experience a suboptimal response. To optimally select...

🎉Hurrah! Our paper is online!
In our most recent study we show that protein profiling of tumor cells can predict how patients with #CLL will respond to treatment with the PI3K inhibitor #umbralisib, either as a alone or with the BTK inhibitor #acalabrutinib.

aacrjournals.org/clincancerre...

22.03.2025 14:29 — 👍 2    🔁 0    💬 0    📌 0
Preview
Longitudinal omics data and preclinical treatment suggest the proteasome inhibitor carfilzomib as therapy for ibrutinib-resistant CLL - Nature Communications The molecular mechanisms underlying resistance to therapy in Chronic lymphocytic leukemia (CLL) remain to be explored. Here, the authors perform multi-omics analysis in a mouse model of ibrutinib resi...

A presentation I gave at the
#EHA congress in 2022 resulted in this nice collaboration with #MartinaSeiffert that confirms findings from our group that #ProteasomeInhibitors may have therapeutic efficacy in relapsed #CLL.

Very nice to see this out!👇

www.nature.com/articles/s41...

29.01.2025 11:19 — 👍 2    🔁 0    💬 0    📌 0

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