Qi Chen

Our 🌷 May 🌷 issue is online with a broad range of article topics and formats!

In their Opinion article (on the cover, too!), @qichen-lab.bsky.social and colleagues describe the interactions between small ncRNAs and Toll-like receptors.

Find the issue here: www.cell.com/trends/bioch...

01.05.2025 20:54 — 👍 5    🔁 3    💬 1    📌 0

Very glad to see our Sequential Activation Hypothesis highlighted on the cover @cp-trendsbiochem.bsky.social , linking small RNA-TLR interactions to autoimmune disease mechanisms.

01.05.2025 17:21 — 👍 4    🔁 2    💬 0    📌 0

Optimized identification and characterization of small RNAs with PANDORA-seq - Nature Protocols This Protocol describes optimized procedures for purification and sequencing of small noncoding RNAs from a variety of samples to characterize these diverse RNA species and map them to the parental RNAs from which they originate.

#NewNProt for #genomewide characterization of a diverse set of #smallnoncodingRNAs in cells and tissues

08.04.2025 10:48 — 👍 2    🔁 1    💬 0    📌 0

We put together a step-by-step protocols for PANDORA-seq, now available in Nature Protocols @natprot.bsky.social , including the sample preparation for sperm, sperm heads; and the analyzing software SPORTS optimized for various types of small RNAs including tsRNAs, rsRNAs, and miRNAs. rdcu.be/egk1Z

04.04.2025 06:10 — 👍 4    🔁 1    💬 0    📌 0

Proud of @jianchengyu.bsky.social and the team for thinking fearlessly to put the ideas together!

16.02.2025 00:38 — 👍 1    🔁 0    💬 0    📌 0

This idea is driven by advanced sncRNA sequencing (e.g. PANDORA-seq), uncovering an expanding universe of tsRNA/rsRNA/ysRNA & more www.nature.com/articles/s41...
These sncRNAs go beyond RNAi, adopting aptamer-like roles by binding TLR7/8 to shape immune responses
www.jbc.org/article/S002...

16.02.2025 00:38 — 👍 1    🔁 0    💬 1    📌 0

TLR7/8 aren’t just triggered by viral RNAs, they can be potentially activated by a range of RNA resources: cell stress/death, RNA therapies, microbiome, and even dietary RNAs.
Uncovering these diverse triggers may pave new paths for preventing/treating autoimmune diseases.

16.02.2025 00:38 — 👍 1    🔁 0    💬 1    📌 0

How can abnormal small RNA biogenesis spark autoimmune disease? Our opinion @cp-trendsbiochem.bsky.social discuss a novel two-stage activation hypothesis that may explain why autoimmunity hits women harder, via small RNA-TLR7/8 interactions & augmented by autoantibodies.
www.cell.com/trends/bioch...

16.02.2025 00:38 — 👍 5    🔁 3    💬 1    📌 1

go.bsky.app/QkSL6S5

05.12.2024 21:23 — 👍 3    🔁 1    💬 0    📌 0

Starting this platform with the excursion to the historic village Shirakawa-go. #tRNA2024 conference at Kanazawa, Japan

30.11.2024 07:26 — 👍 5    🔁 0    💬 1    📌 0