Membranoproliferative glomerulonephritis with diffuse lobular simplification of the glomeruli, caused by extensive endocapillary hypercellularity (Jones silver stain).

#RenalPath: Membranoproliferative glomerulonephritis (MPGN) is a lesion caused by subendothelial immune complex deposits.

bit.ly/4azajpy (FREE)

Hyperkalemia With Empagliflozin and Finerenone | Docwire News Joel Topf, MD, interviewed Rajiv Agarwal, MBBS, about an implementation analysis of CONFIDENCE findings on hyperkalemia with finerenone and empagliflozin in chronic kidney disease.

👀 WATCH NOW: Joel Topf @kidneyboy.bsky.social caught up with Rajiv Agarwal at #KidneyWk in Houston, where the latter presented CONFIDENCE findings on implementation of finerenone and empagliflozin. #nephrology #nephsky #kidneydisease #hyperkalemia #sglt2 www.docwirenews.com/post/hyperka...

Is It Time to Consider Population-Based Urine Dipstick Screening for Early Detection of Kidney Disease? ca. 2025 from @kireports.bsky.social @saynanorouzi.bsky.social
#Nephpearls #KidneyWk #NephSky

👉 www.kireports.org/article/S246...

Why high dose of it if compared to dose in IgA

eGFR outcomes why differ than IgA in spite of proteinurea reduction

Ischemia-reperfusion injury (IRI) is an unavoidable consequence of kidney transplantation, can targeting complement activated via the lectin and alternative pathways help reduce IRI and its clinical impact? Read more in this #ASNJASN #Review kidney.pub/JASN0826

CRS related or immune related podocytopathy

2025 Concise Clinical Guidance:
An ACC Expert Consensus Statement on Medical Weight Management for Optimization of Cardiovascular Health

by Drs. Gilbert, @drmarthagulati.bsky.social, Gluckman, @mkittlesonmd.bsky.social, Rikhi, Saseen, Tchang

What are the best practices for treating patients receiving peritoneal dialysis while hospitalized? This #ASNCJASN "Kidney Case Conference: How I Treat" shares clinician perspective on protocol and procedure. kidney.pub/CJASN0783

NO more with ACEi or ARBs

Effect of losartan on endothelial function in women with history of #preeclampsia

🔗 academic.oup.com/ajh/article/... 🔓

#OpenAccess #Free

Join us for this Global Renal Exercise Group (GREX) Webinar about intradialytic exercise on July 17th. Free registration at: us06web.zoom.us/webinar/regi...

PREVAIL Investigator on Felzartamab’s Potential to Change IgAN Therapy | Docwire News Dr. George Newman of Knoxville Kidney Center discussed the PREVAIL study of felzartamab for IgA nephropathy (IgAN). Dr. Newman is a site PI for the trial.

CHECK OUT our interview with Dr. George Edward Newman, a PI for the #PREVAIL trial of #felzartamab for #IgAN. His Knoxville site recently dosed its first patient. #nephrology #nephsky #iganephropathy www.docwirenews.com/post/prevail...

Good luck

Tirzepatide associated with 1ml/min/yr slower decline in eGfR crcys and decreased albuminuria (30% in those with baseline albuminuria, less for those with normoalbuminuria)! #ada2025

Also PPI could have a roll

American Society of Nephrology | Media Library - <asp:Literal id=

www.asn-online.org/media/podcas...

Some conclusions from a great talk on monoclonal gammopathies of renal significance from Dr. Nasr at @glomcon.org today:

More on BEDMED:
youtu.be/mqkTYElw0fo?...
With @rickyturgeon.bsky.social Dr. Scott Garrison @hswapnil.medsky.social and Dr. Isla Mackenzie
@markusathome.bsky.social

𝗜𝗦𝗡 𝗩𝗜𝗗𝗘𝗢 𝗔𝗕𝗦𝗧𝗥𝗔𝗖𝗧 𝗦𝗘𝗥𝗜𝗘𝗦: The effects of plasma exchange and glucocorticoids on early kidney function among patients with ANCA-associated vasculitis in the PEXIVAS trial. 2025 from @kidneyint.bsky.social www.kidney-internati...

#VideoAbstract by @drsumanbehera.bsky.social

Complement activation in secondary thrombotic microangiopathies

doi.org/10.1093/ndt/...

👉This review summarizes the current understanding and future directions in the management of secondary TMA, emphasizing the potential of complement inhibition as therapeutic strategy

Figure 1 Kidney biopsy day 7 post-admission. A. Light microscopy: numerous isometric osmotic vacuoles within tubular epithelial cells (H&E X400). B. Light microscopy: lymphoid infiltrate consistent with CLL within renal parenchyma (H&E x200). C. Electron microscopy: prominent vacuolization within tubular epithelial cells (uranyl acetate and lead citrate x 1000). D. Electron microscopy: higher magnification showing membrane bound osmotic vacuoles seen separate from mitochondria (uranyl acetate and lead citrate x 6000).

Figure 2 Serum creatinine trend to day 15 of hospital admission. Fenofibrate 145mg administered from day 2 to 6, olanzapine 10mg daily from day 1 and gliclazide 60mg twice daily from day 3. Intravenous fluid therapy continued to day 12. Kidney biopsy performed on day 7 (green arrow).

Interesting case report in @ajkd.bsky.social

Osmotic nephropathy from fenofibrate (or its excipient?)

www.ajkd.org/article/S027...

#NephSky

If true, add to contrast, dextran/starch, mannitol, flozins (pubmed.ncbi.nlm.nih.gov/32387022/)

Any risk to hypoglycemia

Figure 2:eGFR change from baseline over time following dapagliflozin initiation in patients with CKD without type 2 diabetes in the USA in the years 2021–23 (post-approval). *Initiation of dapagliflozin 10 mg.

Dapagliflozin in non-diabetic CKD with low/high ACR - OPTIMISE CKD observational design

Pretty flat GFR slopes?

academic.oup.com/ckj/article/... on @ckj-era.bsky.social

#NephSky #OpenAccess

Lupus nephritis and during pregnancy treatments

⬇️C3/C4 in kidney dz not a coincidence, it’s about injury to the endothelium:
1. SLE III-IV: subendothelial IC (sEnIC), endocapillary prolif (EnCP)
2. IRGN (bact): EnCP, +/- sEnIC
3. MPGN (viral, idiop): EnCP, sEnIC
4. TMA: compl-endothel injury
5. Atheroemboli: chol cryst-endothel injury
#Nephsky

www.acpjournals.org/doi/10.7326/...

Guidelines should protect patients from non expert But experts should protect patients from guidelines

Is it applicable for adults ?!!!

KDIGO GEMs: Glomerular Diseases Join me at #kdigogdgems - A virtual event covering ANCA vasculitis, complement-mediated kidney disease, IgA nephropathy and lupus nephritis

www.gems-gd.org