Jeremy Hogeveen

A reminder that the mRNA vaccine technology saved millions of lives during the Covid pandemic and received the 2023 Nobel Prize for Medicine

I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...

The affective gradient hypothesis: an affect-centered account of motivated behavior Everyone agrees that feelings and actions are intertwined, but cannot agree how. According to dominant models, actions are directed by estimates of va…

Amitai has a nice review on this www.sciencedirect.com/science/arti...

its all that mainlining fresh human blood for absolutely zero reason

#JNeurosci | Hwang, Murray, and colleagues discovered that the orbitofrontal cortex is pivotal to the arousal of the autonomic system in macaque monkeys when they view reward-predictive cues. https://doi.org/10.1523/JNEUROSCI.0619-25.2025

Positive Affect as a Developmental Mediator of Early Adversity and Internalizing Psychopathology Early life adversities (ELAs) including experiences such as abuse, neglect, and household dysfunction are strongly linked to psychopathology; yet, the developmental pathways connecting ELA to external...

🆕 RESEARCH: Not all kids respond to early adversity the same way. We examined data from ~7,400 children for 4 years and found something notable about positive emotions & mental health outcomes...
doi.org/10.1101/2025...

A thread 🧵 #MentalHealth #ChildDevelopment #Resilience /1

Modeling hidden cognitive states reveals acute and chronic effects of fentanyl on decision-making The cognitive mechanisms underlying behavior are often dynamic, shifting gradually or abruptly over time scales spanning years, to weeks, to minutes. Whether drug-induced changes in learning and decis...

I’m excited to share my latest paper, in which we used latent state modeling to reveal how fentanyl shapes decision-making dynamics in rats.

Here’s a summary of what we found (thread).

www.biorxiv.org/content/10.1...

The Neuroscience Dept at American University is hiring for a tenure-track position at the Assistant level with expertise in Computational Neuroscience. Apply by Sep 15:
american.wd1.myworkdayjobs.com/AU/job/Main-...
#FacultyJobs #AcademicJob #Neuroscience #CompNeuro #AI #ComputationalPsychiatry

🚨 New Preprint 🚨

Targeting intracranial electrical stimulation (ES) to network regions defined within individuals causes network-level effects

By Cyr et al.

***
Q: Can we use individualized network maps from precision fMRI to modulate a targeted network via intracranial ES?

A: Yes!

🧵:

Annual Meeting - Cognitive Neuroscience Society March 7 – 10, 2026 Submit a Symposium Submit a Poster CNS 2026 Annual Meeting – March 7 – March 10, 2026 We invite you to join us at the Cognitive Neuroscience Society (CNS) 2026 Annual Meeting, March...

2026 @jocn.bsky.social Travel Fellowship
@jocn.bsky.social and Cog. Neurosci. Soc. to offer a stipend of $3000, plus waived conf. reg. and waived poster submission fee to attend www.cogneurosociety.org/annual-meeti... , to one trainee based at an institution located in each of five regions:

bayesians gotta relax with the taking credit for the concept of infering things about the world

new work just out by (now Dr!) Anna Jos in collaboration with
@awestbrook.bsky.social

how do pupil diameter changes track the behavioral expression of flexible versus stable control?

find out NOW in the latest issue of Psychophysiology :

onlinelibrary.wiley.com/doi/10.1111/...

Our new paper is out! When navigating through an environment, how do we combine our general sense of direction with known landmark states? To explore this, @denislan.bsky.social used a task that allowed subjects (or neural networks) to choose either their next action or next state at each step.

No evidence for a link between mental health symptoms and pain thresholds Previous studies have suggested associations between pain perception and psychological factors such as mood, distress, fatigue, and quality of life. However, these factors and their relationship to...

Does sensitivity to acute pain correlate with mental health?
In our new paper led by @rebeccaboe.bsky.social & @francescafardo.bsky.social we analyzed thermal pain thresholds in 565 adults and found no link to mental health symptoms.
👉 doi.org/10.1080/1061...

Targeting intracranial electrical stimulation to network regions defined within individuals causes network-level effects https://www.biorxiv.org/content/10.1101/2025.07.31.667730v1

Omg that sounds 🔥

Wissenschaftliche*r Mitarbeiter*in (w/m/d) Bewerberfrist: 06.07.2025

We are looking for a Postdoc who loves fMRI, psychophysiology and data analysis 🎉. We run studies on social cognition and related processes with a focus on schizophrenia. German skills could be beneficial, bc the position involves teaching, but not mandatory.
stellen.uni-konstanz.de/jobposting/4...

Null and Noteworthy: Downstream brain areas read visual cortex signals en masse in mice The finding contradicts a theory that the regions prioritize neurons that are adept at identifying specific stimuli. Plus, a response to a study that questioned immune memory in astrocytes.

Some neurons respond more strongly to visual stimuli than others. But the rest of the brain doesn’t prioritize signals from those neurons, according to a new study. Read more in this month’s Null and Noteworthy.

By @ldattaro.bsky.social

#neuroskyence

www.thetransmitter.org/null-and-not...

Me at work: you shouldn’t condition on posttreatment variables as it biases inferences, see Montgomery et al. (2018).

Me at home: look at how sweet the kids are with each other when they’re not fighting!

Strong and sobering signals that need to be understood …

New preprint from collaboration with @sn-lab.bsky.social - 2p imaging of psilocybin's effects on neurovascular coupling 🧠🔬

We found that psilocybin prolongs the neurovascular response, independent of neural activity.

This would affect how we should interpret fMRI BOLD studies of psychedelics ‼️

After today we will have zero kids in ($$) daycare and two kids enrolled at our local elementary and holy crap that went by quickly!

Ugh, so sorry 😞

Almost missed that this is out! Former postdoc Liz Necka led this long overdue FMRI study formally comparing two types of pain modulation: Placebo analgesia & predictive cues. TLDR: these are NOT the same! Placebo analgesia reduced cue effects, & brain mechanisms were nearly all dissociable. 1/4

Looking for @theabcdstudy.bsky.social fMRI timeseries data?It's all in the 6.0 data release, thanks to @drdamienfair.bsky.social and team at ABCC 🧠: docs.abcdstudy.org/latest/docum...

Eye puffs prompt separable sensory, affective brain responses in mice, people Post-puff brain state might not be an emotion, some researchers caution, but the protocol provides a cross-species approach to study emotions.

Can we study emotion by using eye puffs that are "irritating"?
Check this Transmitter piece about the original paper in Science and some views for an against.
@thetransmitter.bsky.social
#neuroskyence
www.thetransmitter.org/emotion-proc...

thrilled to share this project over a decade in the making out now in @pnas.org! We show that precocious GABA boosting in neonates by early sevoflurane/propofol anesthetic exposure accelerates visual cortical maturation in human infants
www.pnas.org/doi/10.1073/...

Hell yeah, keep the pressure on.

If you live in one of these states, call your Senators, thank them, and remind them that there are related issues where their states and the nation needs their support and willingness to stand up.

We put out this preprint a couple months ago, but I really wanted to replicate our findings before we went to publication.

At first, what we found was very confusing!

But when we dug in, it revealed a fascinating neural strategy for how we switch between tasks

doi.org/10.1101/2024.09.29.615736

🧵