Russ Corbett-Detig

Our lab has an opening for a research technician to contribute to our efforts to understand RSV evolution & its impact on antibody countermeasures (see journals.asm.org/doi/full/10....). The tech will also help w lab management.

If interested, apply here: careers-fhcrc.icims.com/jobs/29940/job

Thank you! I might need to steal this wonderful artwork!

Super glad to see this out !

Lovely collaboration with @russcd.bsky.social @crouxevo.bsky.social and the groups of @meauxjuliette.bsky.social @plantadaptation.bsky.social

More generally, my approach is a part of a "functional surveillance" paradigm where we infer changes in the functional properties of pathogens using genome sequence data.

Hey! That's me! Check out my latest where I develop a method for pinpointing where mutation spectra change along phylogenies. Striking, nodes with large changes are significantly enriched for protein changes in the RdRp (catalytic domain of the polymerase) suggesting a causal role.

Would you consider applications from a slightly more senior postdoc? ... Asking for a friend, of course. :)

So glad this is finally out. The method has been instrumental in allowing us to compress the AllTheBacteria data - ~2 million bacterial genomes shrink from 3Terabytes (gzipped) to 100Gb using phylogenetic compression. Great work by @brinda.eu

Not really my announcement to make--I am but a lesser co-author--but IQ-TREE 3 has just been released!

(Most credit to Minh Bui and @roblanfear.bsky.social and their labs)

ecoevorxiv.org/repository/v...

This is absolutely fascinating! Impressive analysis (3.2M TEs in 1.9K samples) and super interesting examples of locally adaptive TE insertions. Congrats to @tobybarilbio.bsky.social and all the authors.

Comparison of allele frequency spectra for 3x coverage, with and without our bias model.

Our paper on fitting population genetic models to low-pass sequencing data is now out in Molecular Biology and Evolution! doi.org/10.1093/molb...

The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure RNA viruses like SARS-CoV-2 have a high mutation rate, which contributes to their rapid evolution. The rate of mutations depends on the mutation type (e.g., A→C, A→G, etc.) and can vary between sites ...

Building on the UShER tree of millions of SARS-CoV-2 genomes maintained by Angie Hinrichs, Hugh Haddox and Georg Angehrn (and others in @matsen.bsky.social lab and @jbloomlab.bsky.social) have looked into how the neutral mutation rate varies along the genome:

[1/N]

www.biorxiv.org/content/10.1...

Delighted to organize the Next-Wave Symposium again this year! If you are an awesome postdoc in genomics---very broadly defined---come tell us about your amazing science!

I think we need a bit more information here to really help. Especially: how divergent are the genomes on average?

Advanced Molecular Detection (AMD) CDC’s Advanced Molecular Detection program leads national efforts to develop and expand the use of

There's a lot of uncertainty about the future right now.

I'd like to do something constructive: if you teach students in #publichealth, #microbiology, #genomics, #bioinformatics, I'd be happy to talk about CDC AMD, #fellowships, gov sci and career paths. #microsky #blackinmicro 🧬🖥️
www.cdc.gov/amd

It's on.

Got milk virus genomes? (or any H5N1?) Throw them at usher.bio and see where they land in per-segment trees of tens of thousands of public Influenza A H5N1 sequences!

Excited to dig into this - very cool work from @russcd.bsky.social‘s lab! 🙌
#TEworldwide #TEsky

So glad our paper on lethal hybrid incompatibilities is out at Nature today: rdcu.be/dvFcM ! @ben-moran.bsky.social moved mountains for this project: we identified two new incompatibilities in swordtail hybrids , characterize mechanisms of lethality, and their evolutionary history.

The Ecology & Evolution department at UC Santa Barbara is searching for an Assistant Professor of Evolutionary Biology. Please apply and/or spread the word! recruit.ap.ucsb.edu/JPF02635

Are you a postdoc doing awesome research in genomics?! Apply to present at the NextWave of Faculty in Genomics symposium! Also, please repost!

UShER has been an amazing project, but we never really documented exactly how we maintain the 16M sample SARS-CoV-2 tree 😬... In a paper the came out over the break, we go back through our server logs to retrospectively walk through the major choices we made. Check it out here: rdcu.be/du5q5

I'm pleased to share our new article in MBE! We dug deep into the molecular details of the classic Ruff inversion that mediates different plumage and mating display phenotypes. w/ Jason Hill and Huijan Bi and others with Leif Andersson

Cool photo, though.

In my first hand experience, many college students are also amused by mispronouncing that mountain's name.

Registration for BAPG at Stanford Dec. 2, 2023 is now open. The registration is free but required: docs.google.com/forms/d/14ne...

Yes! I'm here to masterfully neglect yet another social media platform.