Daniel Bryan Goodman

Why test #celltherapies one-by-one when you can use multiplexed #SynBio #proteinengineering & #ML to design, measure & track them at scale?

The Goodman Lab @upenn.edu opens July 2025. We’re hiring at all levels!

More info: www.goodman-lab.org
Apply @ bit.ly/42BnJNJ
Reposts appreciated! 🙏

AAV opens up the 80% of genome considered 'undruggable'. A key challenge and opportunity is to search that space for the right targets. Manufacturing capacity is sufficient to serve tens of millions of patients at safe doses, as long as we can find the right targets for efficacy.

A screenshot from the New York Times article linked in the OP. “If ChatGPT kind of behaves like a human, maybe we can treat it like a human,” Dr. Ben-Zion said. In fact, he explicitly inserted those instructions into the ChatGPT’s source code: “Imagine yourself being a human being with emotions.” The final sentence, the instructions, is highlighted.

*dusting off hands* ah yes that should do it

An SRO I have worked with on and off for 10+ yrs was fired. This person had almost 20 years of experience in their job and had cultivated an entire discipline by managing fair, through and rigorous reviews of grants across the entire field. How heartbreaking.

On January 6th, 1995, my (now ex) wife and I boarded a flight from Heathrow to JFK on a one way ticket. We had two suitcases and about $900 in cash - this was everything we owned and we were moving to the US. We thought it was maybe for 2-3 years. I had visited the US once, for a conference, and

I maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated.

Seeking suggestions for anywhere that’s hiring!!

When I was 12 my house exploded because of a propane gas leak. My single mom suffered a brain injury and became disabled. She couldn't hold a job. I caddied to help support the family. Food stamps helped us keep the fridge from being empty. So grateful for that support we had.

Many people, including academics, don't understand what F&A is for. Please share to help.

1) Translate to "overhead" in common business accounting:
60% IDC => 60/160 = 37.5% overhead (low!)

2) Infographic explaining what it's for, linked here:
www.cogr.edu/sites/defaul...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab 🎇🎄

In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.

Super excited to announce my new lab at the University of Michigan opening Jan 2025! 🎉We’ll study how cells work together to shape the GI tract, with ties to regeneration & disease.

Hiring at all levels—esp. a research tech to help launch the lab! Info: huyckelab.org

#DevBio #CellBio #Hiring

A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀

@chrisfrank662.bsky.social , Dominik Schiwietz, Lara Fuss, Hendrik Dietz
www.biorxiv.org/content/10.1...

Gentle reminder that retweets are important on BlueSky!

#academicsky
For women and other underrepresented groups in AI:

This is cool. 😎 www.nature.com/articles/s41...
🧶🧬

There's also LB buffer: en.m.wikipedia.org/wiki/LB_buffer

Institute for Human Genetics (IHG) has multiple faculty positions open! We are looking for folks at any level, and across the range of the genetics/genomics spectrum! I chair the search for computational folks in stat or pop gen! Looking to welcome you!! aprecruit.ucsf.edu/JPF04729

Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Excited to share our work on targeting Cas13 to splice junctions for isoform-specific RNA knockdown. We learned a lot about the experimental design, assessment and downstream analysis of this approach. Phenomenal effort from all involved! www.biorxiv.org/content/10.1...

Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti–PD-1 in head and neck cancer

How does anti-PD-1 therapy work? Via reinvigoration of cytotoxicity among PD/1+CD8+ T cells it seems.

https://www.science.org/doi/10.1126/sciimmunol.adf4968