John Matson

Localized delivery and retention of hydrogen sulfide causing regional lipid accumulation in mouse adipose tissues in vivo - Communications Biology Locally delivered H2S slow-releasing hydrogel promotes lipid accumulation, adipocyte hypertrophy, macrophage infiltration, and fibrosis in mouse adipose tissue, offering a practical implementation str...

NEW PAPER ALERT!! We are excited to share about our publication in collaboration with Rui Wang's group from York University published in @commsbio.nature.com !! Shout out to all the authors and congratulations to Ishani and Matson lab alumni Kuljeet!

doi.org/10.1038/s420...

07.07.2025 18:30 — 👍 1    🔁 1    💬 0    📌 0

Congratulations to our Lab Mom Sarah on her recent publication in Biomacromolecules @pubs.acs.org! This paper was published in collaboration with Baker, Moroni and Wieringa groups at @merln-um.bsky.social. We thank @nwofunding.bsky.social for the funding. Cheers to all!

pubs.acs.org/doi/10.1021/...

04.08.2025 14:55 — 👍 1    🔁 1    💬 0    📌 0

Cellular Uptake and Antioxidant Activity of H2S-Releasing Tetrapeptide Supramolecular Polymer Nanostructures Self-assembled peptide–H2S donor conjugates (PHDCs) can deliver hydrogen sulfide in vitro and in vivo, yet the link between the supramolecular nanostructure morphology and cellular uptake remains unclear. Herein, we designed constitutionally isomeric PHDCs that self-assembled in aqueous solution into either nanoribbons, nanofibers, or nanobelts with various dimensions based on cryogenic transmission electron microscopy and small-angle X-ray scattering. Nile-red loaded PHDCs showed morphology-dependent uptake by H9C2 cells based on fluorescence microscopy combined with flow cytometry and confocal imaging, where narrow, helically twisted nanoribbons entered most efficiently. All PHDCs released H2S at similar rates, but the amount of H2S released inside the cells depended on the internalization ability of each PHDC. Consistent with these results, the narrow twisted nanoribbons afforded the greatest protection against H2O2-induced oxidative stress. Overall, this study highlights how subtle molecular-level changes can influence nanostructure formation in supramolecular assemblies and ultimately affect their cellular uptake and biological activities.

Brace yourself World! We have another new publication in hand! Congratulations to our dearest Dr. Zhao, Bushra, Ishani
and Clark for their paper in ACS Material Letters @pubs.acs.org in collaboration with Bitton group from @bengurionuni.bsky.social and Yin Wang! Hurray🥳

pubs.acs.org/doi/10.1021/...

11.08.2025 14:49 — 👍 1    🔁 1    💬 0    📌 0

A BIG shout out to our awesome PMSE Best Undergraduate Student Poster judges. They came to #ACSFall2025 not only to discuss science but also to contribute to our community. Thank you! #science #chemistry #polymer #Students #Award @AmerChemSociety

21.08.2025 08:22 — 👍 3    🔁 1    💬 0    📌 1

This effort has been several years in the making, so we're excited that it is finally ready for public review. Please let us know what you think!

14.08.2025 11:18 — 👍 4    🔁 1    💬 1    📌 0

Travel to Malaysia begins today! Here I come #IUPAC2025 General Assembly and World Chemistry Congress. Looking forward to seeing many friends in iupacpolymer.bsky.social!

09.07.2025 09:20 — 👍 6    🔁 0    💬 0    📌 0

We are delighted to welcome Spencer Kearns over the summer as a part of VT's REU program. Spencer is senior at VT majoring in BS Chem. We look forward to experience some exciting research in polysaccharides from him soon!

03.06.2025 17:22 — 👍 1    🔁 1    💬 0    📌 0

Looking forward to having you join us in the @iupacpolymer.bsky.social as well!

07.05.2025 12:54 — 👍 1    🔁 0    💬 1    📌 0

Agreed! Great stuff #apme2025

07.05.2025 12:53 — 👍 1    🔁 0    💬 1    📌 0

Super excited to see this finally come out! Check out the fun TEM images. More are on the way!

04.05.2025 10:45 — 👍 4    🔁 0    💬 0    📌 0

Our undergrads Thomas, Deckland and Alex did a great job at the Undergraduates poster session in the HHS atrium today! We are super proud of their achievements and hard work !!

02.05.2025 20:23 — 👍 3    🔁 1    💬 0    📌 0

Sarah and I went to the Netherlands for her 2nd PhD defense! Now she has a PhD jointly awarded from @vtchemdept.bsky.social & @maastrichtu.bsky.social with a diploma the size of a large suitcase to prove it. Her 5 'opponents' put her through the ringer, but she came out victorious. Congrats, Sarah!

14.03.2025 19:59 — 👍 5    🔁 1    💬 0    📌 0

We enjoyed this collaborative work with groups from @vtchemdept.bsky.social and VT ChemE. Thanks to #GlycoMIP for funding and overall organization of our glycomaterials efforts!

08.01.2025 16:06 — 👍 3    🔁 1    💬 0    📌 0

Hi all, joining Bluesky today. Looking forward to discussions on #polymers, #chemistry, #H2S, #peptides, #biomaterials, and many other topics!

18.11.2024 19:39 — 👍 7    🔁 0    💬 1    📌 0