SciLifeLab

Exciting opportunity at @scilifelab.se

Ep2: We take a look at the wider #biodiversity crisis and the vital ecological roles butterflies play. 🌍🧪

▶️ youtube.com/watch?v=tTcqzUlwLsE

💬 Mariana Pires Braga, @jhog.bsky.social‬, Niclas Backström

@uu.se
@animecol-uu.bsky.social
@evobiouppsala.bsky.social
#EvoSKy #Conservation #ClimateChange

Staff scientist in Bioinformatics and Data Science

🧪🖥️VACANCY - Are you experienced in machine learning, bioinformatics or advance statistical methods?🧬

Become a Staff Scientist in Bioinformatics & Data Science @nbis.se & @scilifelab.se and help explore molecular, imaging, clinical and/or epidemiological data.

More info👇:
www.umu.se/en/work-with...

Hear more about the weird—sorry, different—life history of the clouded apollo butterfly from Niclas Backström (@uu.se / @evobiouppsala.bsky.social) on YouTube! 🌍🧪 ↓
www.youtube.com/watch?v=ObOH...

#EvoSKy #EvoBio #Conservation #BioDiversity #Ecology #Butterflies

A cell-based degrader assessment platform facilitates discovery of functional NUDT5 PROTACs Targeted protein degradation (TPD) via PROTACs and molecular glues holds significant therapeutic promise but demands detailed mechanistic evaluation in live cells to fully understand compound behavior...

🚨 Happy to finally share our first @biorxivpreprint.bsky.social on PROTACs and TPD with Mikael Altun and DDDP @scilifelab.se. 🚨

We develop a suite of cell-based methods to assess degrader functionality and show this with new PROTACs toward NUDT5 as PoC.

👇
www.biorxiv.org/content/10.1...

🧵 1/4

🎥 Hear from: ↓ 🌍🧪
• @jhog.bsky.social, SciLifeLab /
@uu.se / @animecol-uu.bsky.social
• Martin Elmestål, County Administrative Board of Stockholm
• Mariana Pires Braga, SLU & Fellow at SciLifeLab
• Niclas Backström, @uu.se / @evobiouppsala.bsky.social‬.

#EvoSKy #EvoBio #Conservation #BioDiversity

YouTube video by SciLifeLab The Endangered Clouded Apollo | To Save a Butterfly – mini-series Ep 1/3

In this first episode of a three-part documentary mini-series, we explore how habitat loss threatens this species, and what is done about it. 🌍🧪

▶️ Watch Episode 1 here ↓ www.youtube.com/watch?v=ObOH...

📌 Subscribe on YouTube to catch Episodes 2 & 3!

#EvoSKy #EvoBio #Conservation #BioDiversity

🦋 The #CloudedApollo is disappearing – but scientists and conservationists are stepping in to help. 🌍🧪

Episode 1 of our new mini-documentary is out now! 🎬

▶️ Watch Episode 1 here: www.youtube.com/watch?v=ObOH...

#EvoSKy #EvoBio #Conservation #BioDiversity

SciLifeLab Course Sparked International Art and Inclusion Project What does belonging in STEM look like – and who gets to decide? This question sparked Code Couture: Breaking the STEM Dress Code, a visual arts project that by Anabella Aguilera exploring how gender, ...

SciLifeLab Project Coordinator Anabella Aguilera, who initiated the project, tell us more about the project below ↓ 🧪
www.scilifelab.se/news/scilife...

#NonBinaryInSTEM #WomenInSTEM #ArtAndScience

Collages from Code Couture: Breaking the STEM Dress Code, a visual arts project that explores how gender, appearance, and clothing intersect with perceptions of credibility and inclusion in science and tech.

People from a distance at the FemTech + Feminist Tech Exhibition at KTH Royal Institute of Technology, where Code Couture: Breaking the STEM Dress Code project was displayed

Quotes from the exhibition printed on small papers and laid out on a off-white surface

What does belonging in STEM look like – and who gets to decide? This question sparked Code Couture: Breaking the STEM Dress Code, a visual arts project that explores how gender, appearance, and clothing intersect with perceptions of credibility and inclusion in science and tech. 🧪

#NonBinaryInSTEM

We are accepting applications for a PhD opportunity at @scilifelab.se

this is part of a MSCA Doctoral Network on the topic of metabolic regulation of genome function and cell identity.

A EU funded generous fellowship is offered with possibility of industry experience. Apply here:

🔦 PANCAID Partner Spotlight: @uu.se
The labs of @masoodkamali.bsky.social & @globischlab.bsky.social bring cutting-edge EV, proteomics & metabolomics expertise to PANCAID.
🟣 Working together on biomarker discovery in WP2.

@scilifelab.se
#Metabolomics #CancerResearch

🌎🧪💙

Thanks @scilifelab.se for the highlight of our recently published study @natgenet.nature.com.

Link to the full paper here: rdcu.be/eqGgf

More on this can be found here ↓ 🧪 www.scilifelab.se/news/mini-in...

#MolBiol

YouTube video by SciLifeLab Lab-grown mini-organs help uncover how pathogens cause disease

“we used mini organs, specifically mini-intestines, and infected them with a dangerous bacterium called Shigella” says @mldm.bsky.social‬

@sellinlab.bsky.social‬ (SciLifeLab & @uu.se) shows that cultured mini-organs can uncover how pathogens cause disease

youtu.be/xG_66ZGd_fk

Matthias Zepper & @phd-council.bsky.social recently organized a photography workshop. 🧪📸

“It was rewarding to see the participants bring their scientific mindset, including patience and curiosity, and apply it to photography” says Matthias Zepper, bioinformatician at @scilifelab-ngi.bsky.social

Fin Whale as a Sink of Legacy and Emerging Contaminants: First Integrated Chemical Exposomics and Gene Expression Analysis in Cetaceans Cetaceans face numerous anthropogenic chemical stressors in global oceans, yet there is a lack of studies that simultaneously assess their cumulative exposure to both legacy and emerging contaminants and their combined effects. To evaluate the susceptibility of fin whale (Balaenoptera physalus) to chemical pollution, this study employed for the first time a multidiagnostic molecular approach that integrates chemical exposomics and gene expression analysis in live-sampled skin and blubber biopsies from two distinct populations: the endangered Mediterranean subpopulation (Italy) and the vulnerable population from the Sea of Cortez (Mexico). Both marine regions are biodiversity hotspots characterized by different anthropogenic impacts, making them ideal for the assessment of heterogeneous contaminants exposure and their effects. Results revealed distinct exposure profiles in the two populations, with Mediterranean fin whales exhibiting higher concentrations of legacy pollutants such as polychlorinated biphenyls (PCBs), as well as plasticizers, perfluoroalkyl substances (PFAS), while both populations showed traces of pharmaceuticals and lifestyle-related chemicals (e.g., paracetamol, diclofenac, nicotine, UV filters) and other substances not previously reported in whales. Supported by 32 network correlations with gene expression relevant to transcriptional regulation, endocrine disruption, lipid homeostasis, and inflammation, our findings suggest that complex anthropogenic chemical exposures may compromise the health and reproductive viability of the endangered Mediterranean fin whales, affirming their importance as a global sentinel species, which reflects marine ecosystem integrity within the “One Health” framework.

🐋 New Research Alert!

Whales are majestic sentinels of ocean health. Here we uncover fin whale's exposure & response to legacy & emerging chemical contaminants

🤿 Dive into the full story:
pubs.acs.org/doi/10.1021/...

#ChemicalExposomics #MarinePollution
@scilifelab.se @stockholm-uni.bsky.social

Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids | mBio Pathogenic bacteria employ partially overlapping sets of virulence factor functions to colonize host epithelia but can differ markedly in their pathogenesis and disease kinetics. This work combines ba...

Out now @mbio.bsky.social !: We provide a time-resolved map comparing #Salmonella and #Shigella epithelial colonization strategies in human #enteroids and #colonoids. Connecting the dots among decades of molecular findings reg. underlying virulence factors.

journals.asm.org/doi/10.1128/...

So nice to be featured alongside other fellow colleagues doing research in Planetary Biology at @scilifelab.se 😁

Read more about our research bellow :)

Congrats Werner!

SciLifeLab’s contribution to biodiversity – insights from five scientists On this year’s Biodiversity Day, SciLifeLab researchers share how their work is helping us better understand – and protect – the living world around us.

“Only by grounding our actions in robust scientific knowledge can we preserve biodiversity in a changing world,” says Anabella Aguilera, Scientific Coordinator at the SciLifeLab Planetary Biology strategic area. 🧪🌏

Read the whole Q&A here ↓
www.scilifelab.se/news/scilife...

Researchers in the Q&A: @cstairs.bsky.social (@lund-university.bsky.social ), @gmkov.bsky.social (@uu.se), @rootsofthenorth.bsky.social (Swedish University of Agricultural Sciences – SLU), @mafaldaferreira.bsky.social (@stockholm-uni.bsky.social) & @mehrshmali.bsky.social (SLU)

Close-up of SciLifeLab researcher Gabriela Montejo-Kovacevich with a butterfly on her nose. The logo of the International Day for Biological Diversity is also visible

🌱 On this year’s #BiodiversityDay, five SciLifeLab researchers share how their work is helping us better understand – and protect – the living world around us. 🧪🌏

Full article ↓
www.scilifelab.se/news/scilife...

Scientists reveal how energy is delivered into the cells major “shipping port” - Department of Biochemistry and Biophysics Scientists reveal how energy is delivered into the cells major “shipping port” - Department of Biochemistry and Biophysics

A research team led from Stockholm University & @scilifelab.se has answered a long-standing question in cell biology, uncovering how the cell’s main energy currency, ATP, is transported into the endoplasmic reticulum (ER). The study is published in @nature.com.web.brid.gy
www.su.se/department-o...

🧪

Our work “AI4CellFate: Interpretable Early Cell Fate Prediction with Generative AI” is finally out in
@biorxivpreprint.bsky.social !!! 😍❤️ biorxiv.org/content/10.1... @scilifelab.se , @crick.ac.uk . More about it in the thread #AI4CellFate (1/n)⬇️

Nano technology meets art – the world's smallest Dala horse created at UCEM In a unique meeting of nano technology and cultural heritage, a microscopic Dala Horse – the iconic Swedish wooden horse – has been sculpted using a focused ion beam at Umeå Centre for Electron Micros...

(2/2) Being no larger than 7 micrometers, this sculpture pushes the boundaries of both technology and imagination. 🧪

The artist, Erik Olof Wiklund, collaborated with staff scientist UCEM to carve the horse from a piece of platinum.

Learn more: scilifelab.se/news/nano-te...

Artist Erik Olof Wiklund, student at Umeå Academy of Fine Arts, has together with staff scientist Nils Hauff pushed the boundaries of both technology and imagination – creating the world’s smallest Dala horse, the same size as a human red blood cell.

Artist Erik Olof Wiklund, student at Umeå Academy of Fine Arts, watch images of the Dala horse together with staff scientist Nils Hauff

Close-up of the Dala horse

Image of the Dala horse

(1/2) The world’s smallest Dala horse! 🧪

What happens when you combine an #ElectronMicroscope with an artist's vision?

At UCEM, a SciLifeLab unit at @umeauniversitet.bsky.social, the tiny Dala horse was created using a FIB-SEM.

Photos: Erik Olof Wiklund, Nils Hauff, Mattias Pettersson.
#FIBSEM

🧪