Håvard Lindholm

Repeats mimic pathogen-associated patterns across a vast evolutionary landscape An emerging hallmark of disease is transcription of pathogen-associated molecular patterns from within the genome–known as viral mimicry. We propose a statistical physics framework to measure “selecti...

Excited to have this paper out today!

Repeats mimic pathogen-associated patterns across a vast evolutionary landscape."

It was a fun and productive collaboration with Benjamin Greenbaum John LaCava, Simona Cocco, Petr Šulc and many others!

www.cell.com/cell-genomic...

Repeats mimic pathogen-associated patterns across a vast evolutionary landscape An emerging hallmark of disease is transcription of pathogen-associated molecular patterns from within the genome–known as viral mimicry. We propose a statistical physics framework to measure “selecti...

Nice to see this story out! The idea that viral mimicry is an intrinsic feedback mechanism for sensing cellular dysregulation is fascinating and this paper explores this idea really well.

It was inspiring to be part of this collaborative work. Thanks to @bengrbm.bsky.social and the rest!

😂

Congratulations to Dr. Daniel De Carvalho (@daniel-decarvalho.bsky.social) on winning the 2025 Gairdner Momentum Award! 🎉

His impactful work in cancer epigenetics is revolutionizing early detection and treatment. A well-deserved honour! 👏

🔗 www.uhnresearch.ca/news/gairdne...

Chronic viral mimicry induction following p53 loss promotes immune evasion Abstract. Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through ‘viral mimicry’ responses. Paradoxically, cancer-initiating events also facili...

Our recent work on Viral mimicry escape in Ovarian Cancer is out at Cancer Discovery: aacrjournals.org/cancerdiscov...