Schlisio_lab @schlisio-lab - Bluesky Profile

Huge congrats

03.10.2025 05:28 — 👍 1 🔁 0 💬 1 📌 0

🙏 With fantastic collaborators incl. @ChrisJuhlin, @MichaelMints & team!
#PPGL #CancerResearch #TumorOrigin #StemCells #SingleCell

22.07.2025 13:10 — 👍 0 🔁 0 💬 0 📌 0

5/ DLK1-NOTCH signaling emerges as a key axis in chromaffin–sustentacular cell communication. DLK1 may act as a therapeutic vulnerability in PPGL.

22.07.2025 13:10 — 👍 0 🔁 0 💬 1 📌 0

4/ Some PPGL shows widespread SOX2 in PHOX2B+ tumor cells, linking SOX2 to stem-like states & impaired differentiation via ASCL1.

22.07.2025 13:10 — 👍 0 🔁 0 💬 1 📌 0

3/ In VHL-mutated paragangliomas, a subset of these sustentacular cells carries 3p loss—the hallmark of tumor cells—suggesting a shared clonal origin.

22.07.2025 13:10 — 👍 0 🔁 0 💬 1 📌 0

2/ These cells are distinct from embryonic neural crest and Schwann cell precursors and exhibit a unique progenitor signature, verified by in vivo lineage tracing & snRNA-seq.

22.07.2025 13:10 — 👍 0 🔁 0 💬 1 📌 0

1/ We identify SOX2+/SOX10+ sustentacular glia-like cells in mouse and human adrenal medulla & organ of Zuckerkandl as postnatal chromaffin progenitors.

22.07.2025 13:10 — 👍 0 🔁 0 💬 1 📌 0

Can support glia become cancer cells? Our study identifies SOX2⁺ postnatal chromaffin progenitors that may serve as tumor-initiating cells in paraganglioma. Figure 7 we inferring CNA from VHL related PPGL pre-neoplastic sustentacular cells sharing 3p deletions with tumor cells.

22.07.2025 13:10 — 👍 0 🔁 0 💬 1 📌 0

Postnatal Sustentacular Cells as Chromaffin Progenitors and Tumor Cells of Origin in VHL-Related Paragangliomas The cellular source of chromaffin cell regeneration after birth and its relationship to paraganglioma tumorigenesis remains incompletely defined. Here, we identify a postnatal population of SOX2/SOX10...

Interested in paraganglioma, progenitors, and tumor cells of origin?
Postnatal SOX2⁺ sustentacular glia as chromaffin progenitors can serve as tumor cells of origin in VHL-mutated paragangliomas:
www.researchsquare.com/article/rs-6...

#PPGL #CancerResearch #StemCells #TumorOrigin #SingleCell

22.07.2025 13:06 — 👍 0 🔁 0 💬 1 📌 0

'Positive review only': Researchers hide AI prompts in papers Instructions in preprints from 14 universities highlight controversy on AI in peer review

asia.nikkei.com/Business/Tec...

15.07.2025 15:03 — 👍 0 🔁 0 💬 0 📌 0

YouTube video by Igor Adameyko Cyerce kikutarobabai nudibranch from Okinawa

I worked a bit longer on my pink nudibranch video collection resulting from my Okinawa trip (visiting colleagues at OIST). Now the full video is on youtube: youtu.be/-YF9AQxVYS0?...

21.06.2025 11:38 — 👍 23 🔁 3 💬 2 📌 0

Big congrats!

29.05.2025 12:23 — 👍 1 🔁 0 💬 0 📌 0

The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine Nature Neuroscience - The neuronal composition of the intestinal submucosal plexus is incompletely understood. Here Li et al. define their neuron classes, connectome and stepwise acquisition of...

Check out our new study on the innermost nervous system of the body—the submucosal plexus. We define three neuronal classes, map their connectivity, and uncover their stepwise development via phenotypic switching. Congrats to all authors! #NatureNeuroscience #EntericNervousSystem rdcu.be/eoqXz

29.05.2025 11:28 — 👍 16 🔁 6 💬 1 📌 2

Big congrats!

16.05.2025 11:23 — 👍 1 🔁 0 💬 0 📌 0

Really amazing !

10.05.2025 08:50 — 👍 1 🔁 0 💬 0 📌 0

Beautiful work! Big congrats!

10.05.2025 08:49 — 👍 0 🔁 0 💬 1 📌 0

Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity Neuroblastoma, the most prevalent extracranial pediatric solid tumor, arises from neural crest progeny cells. It exhibits substantial developmental pl…

1/9 🚀 Our latest findings in
@cp-devcell.bsky.social : #Neuroblastoma cells aren’t locked into one single fate—they flip between developmental programs, driving tumor heterogeneity and malignancy. www.sciencedirect.com/science/arti...

09.05.2025 22:02 — 👍 12 🔁 6 💬 2 📌 0