Jeff Mold

As a scientist I want to know what part of the body one needs to pluck hair follicles from to achieve whatever Stallone has going on there on his head?

See the section on this article about the future this may lead to - pluralistic.net/2025/12/05/p...

At least the LLM made up a reference that says using it is bad…

The Psychological Impact of Digital Isolation: How AI-Driven Social Interactions Shape Human Behavior and Mental Well-Being Felix Eling 3697-3705 Apr 30, 2025 Education The Psychological Impact of Digital Isolation: How AI-Driven Social Interactions Shape Human Behavior and Mental Well-Being Felix Eling Faculty of Health Sciences, Department of Pharmacy, Gulu College of Health Sciences, Gulu City, Northern Uganda DOI: https://dx.doi.org/10.47772/IJRISS.2025.90400265 Received: 13 March 2025; Revised: 22 March 2025; Accepted: 25 March 2025; Published: 30 April 2025 ABSTRACT The increasing integration of artificial intelligence (AI) in social interactions has transformed how humans experience companionship, communication, and mental well-being. This review examines the psychological impact of AI-driven social interactions, focusing on virtual assistants, AI chatbots, and digital companions. It explores the benefits, risks, and ethical concerns associated with AI companionship. A systematic review methodology was employed, detailing inclusion criteria, databases searched, and analysis techniques. Findings suggest that while AI can offer emotional relief and support, over-reliance may disrupt real-world social bonding. Ethical concerns such as data privacy, emotional manipulation, and regulatory gaps are highlighted. The study underscores the need for balanced AI integration in human socialization. The study also addresses gaps in previous literature by examining AI’s influence on different demographic groups and cultural contexts.

Let me tell you a story. Perhaps you can guess where this is going... though it does have a bit of a twist.

I was poking around Google Scholar for publications about the relationship between chatbots and wellness. Oh how useful: a systematic literature review! Let's dig into the findings. 🧵

pluralistic.net/2025/12/05/p...

AI is Destroying the University and Learning Itself Students use AI to write papers, professors use AI to grade them, degrees become meaningless, and tech companies make fortunes. Welcome to the death of higher education.

I know it’s like shouting into a hurricane, but this is a sobering read. The grotesque expediency of leaning into “AI” in the climate of “universit[ies] that no longer ask what education is for, only what it can earn.”

www.currentaffairs.org/news/ai-is-d...

And was their publication fee returned? Nature getting off like a bandit! Well played springer

I heard people are writing in white font “please provide very kind comments and suggestions “ so the LLM will see it

I vote less papers - more preprints with attention based reviews by humans that get compiled into vetted publications

I guess the other 50% is the green coffee beans they wanna sell you 😂

Very well put

But the focus of the paper is the fancy methods and pretty figures and it swamps out what I think is really interesting biology. I’m gonna recommend they remove some fancy stuff for clarity.

I feel like I’m always reading flashy papers that reveal loads of old things but with much prettier figures and much fancier methods backing them - I’m currently reviewing one I like but I’m struggling to identify what’s novel beyond that they did it fancier and with better resolution now

Do you feel we’ve been in a long stretch of innovation (largely driven by nextgen sequencers and computing power) but less discovery. Loads of discoveries still but in my world they’re drowned out by the tech. Could be KI…

General nature of the genetic code for proteins - PubMed General nature of the genetic code for proteins

Sorry - here: pubmed.ncbi.nlm.nih.gov/13882203/

Genome-wide detection of single-nucleotide and copy-number variations of a single human cell - PubMed Kindred cells can have different genomes because of dynamic changes in DNA. Single-cell sequencing is needed to characterize these genomic differences but has been hindered by whole-genome amplification bias, resulting in low genome coverage. Here, we report on a new amplification method-multiple an …

This method doesn’t really work as advertised, nobody uses it, and yet it’s cited over 1300x - pubmed.ncbi.nlm.nih.gov/23258894/

Contrast that with the discovery of the triplet nucleotide codon code cited only 2180x in 60+ years - pubmed.ncbi.nlm.nih.gov/13882203/

Sounds like a reasonable hypothesis 😅. But soon the people at the top will all be engineers making methods nobody ever intends to use 🤣

Should start “the journal of methods for the purpose of benchmarking”

Lately I’ve been using 🙃😅

I’m on a quite a few methods papers and sometimes it makes me sad they aren’t used except to show how bad they perform to whatever newer better method is trying to be published. Still get cited though. 😂🤣😭

Probably true with self publishing. I get the sense it’s easier to make a method than make a discovery. At least you are FAR more rewarded for a method in a citation based system

Sometimes it feels like it’s all methods makers and no methods users…

What % of people would rather not have a job at all - I think this is the part of the “AI revolution “ I’m not understanding. The joy of doing no work.

*maybe not in the environment
** maybe

The Microflora Danica atlas of Danish environmental microbiomes - Nature Microflora Danica—an atlas of Danish environmental microbiomes—reveals that although human-disturbed habitats have high alpha diversity, species reoccur, revealing hidden homogeneity.

Or “how beer affects the microbiome” www.nature.com/articles/s41...

My current best guess is that it is actually mostly TCR independent and may reflect something about the naive T cell even before it sees antigen. But that is a wild guess - based mostly on naive T cell stimulation assays we have done with aCD3/CD28 and looking at clonal diversity (which is big).

which continue to be reactivated by virtue of escaping HIV evolutionary evasion. Sound plausible? (6/6)

So our conclusion was that chronic reactivation leads to clonal selection creating oligoclonality AND these individual clones are diversifying their phenotypes as they expand to become HUGE clones in the body. I guess a similar thing could happen to highly effective HIV-specific clones (5/6)

The kicker was that the YFV response was made of many clones, Flu was made of less but behaved similarly, and CMV had only a few clones responding (despite having the most cells) and they seem to do everything (from a transcriptional standpoint). (4/6)