Gonçalo Castelo-Branco

Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)

🚨 Don’t forget to register for #Neuroepi25!
⏳ The deadline is fast approaching - Thursday 7th August 2025.
This is your last chance to join; don't miss out on a fantastic meeting!
Click here to register➡️ bit.ly/4f5Zpbq
#FusionNeuro #FusionAgingResearch #FusionEpigenetics

12th Dev Brains:

@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles

news.ki.se/calendar/dev...

@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social

Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1

@carlstrom.bsky.social Clemens Ries, and Ting Sun rocking at #GLIA2025! And the launch of the Carlström lab!

Great to catch up with @rongfan8.bsky.social in Marseille, where we both end up for two completely unrelated conferences!

The call just opened!

ki.se/en/about-ki/...

You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics

ki.varbi.com/what:job/job...

Heads-up for major new faculty search at KI — with great startup packages and a wide range of subject areas.

Come and join us! Start your group at Karolinska Institutet @ki.se!

📢 Big news! #Neuroepi25 has just released the final programme!
👉 Check it out now on the conference website
✅ And don't forget to register - this is a conference you won’t want to miss!
Click here for more information: bit.ly/3SWoIlO

Have you registered yet for #ReThinkNeuroimmunology in October?
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more

Thanks all speakers, chairs, panelists, MS patients and other participants that joined us at Karolinska Institutet @ki.se and that made this Symposium an unique thinktank (on the true sense of the word) on MS.

...and it is a wrap! 4 days of fantastic talks and brainstormings on the molecular and cellular mechanisms of multiple sclerosis and how this knowledge has been leading to disease-modifying treatments. And what we still don't know and where we are/should be moving towards.

Postdoc in Single Cell Genomics, Jens Hjerling-Leffler group, Karolinska Institutet Do you want to contribute to top quality medical research? The position is located within The Division of Molecular Neurobiology in the lab of Professor Jens Hjerling-Leffler at the Department of Medi

Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...

Join us for the 2025 GRC Genome Architecture www.grc.org/genome-archi... @spp2202.bsky.social @jobdekker.bsky.social @metorrespadilla.bsky.social @jopkind.bsky.social @dimplenotani.bsky.social @stanleyqilab.bsky.social @andybelmont.bsky.social @fondufemittendorf.bsky.social @boyanbonev.bsky.social

Happy to share that I will kickstart my research group at @ki.se this autumn!🎉🎉 Are you interested in glial biology, using high-end tools for gene and cell programming to study metabolic and epigenetic interactions? Stay tuned! Will be 🔭 for RA, PhD-students & postdocs!
Let the journey begin! 🧬🧫🔬

Today!

Thanks for such a great meeting!

Night science is improvisations, openness, import/export, puzzle switching, hypothesis liabilities, anthropomorphisms, finding questions, contradictions & awe in science; as we discussed in the legendary Karolinska Institute. 🙏 @kragesteen-lab.bsky.social Christoph Ziegenhain & Rickard Sandberg

It was amazing to do a Night Science workshop today at the Karolinska Institute in Stockholm!

Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...

For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker

www.nature.com/articles/s41...

Seminar: "Coordinated remodeling of neural stem cell epigenome and cell fate bias during cortical development" Welcome to a seminar with Dr. Boyan Bonev, Helmholtz Zentrum München, Germany.

Come and listen to @boyanbonev.bsky.social, monday May 26th, 3pm, at Biomedicum @ki.se !

news.ki.se/calendar/sem...

Brain Tumor Plasticity A growing body of evidence emphasizes the presence of significant intra-tumoral phenotypic diversity and plasticity within brain tumors. Inherent plasticity introduces an additional layer of intricacy...

🎫 Exclusive event: One-day symposium on #Brain #Tumor #Plasticity
🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social

Few spots available. Register here: ui.ungpd.com/Events/ed387...

Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity Neuroblastoma, the most prevalent extracranial pediatric solid tumor, arises from neural crest progeny cells. It exhibits substantial developmental pl…

1/9 🚀 Our latest findings in
@cp-devcell.bsky.social : #Neuroblastoma cells aren’t locked into one single fate—they flip between developmental programs, driving tumor heterogeneity and malignancy. www.sciencedirect.com/science/arti...

Epichrom 2025 !

After 3 years, Epichrom is revived and will take place in Stockholm on the 12th of June. Great opportunity to share your research and hear about latest epigenetics/chromatin research in Sweden.

Registration is free of charge
www.bartosovic-lab.com/epichrom

Europe’s choice is clear.

To put science at the heart of its economy.

To become the home of scientific freedom and collaboration.

And to welcome talent from all over the world.

I’m glad to present the first elements of our Choose Europe Initiative.

→ europa.eu/!TTbWbJ

Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traits Spatially resolved transcriptomics is transforming our understanding of cellular and molecular diversity of tissues. Here, to identify tissue structures that are enriched for putatively causal disease...

New preprint! My (now former) postdoc @kvastad.bsky.social led this integration of GWAS and spatial transcriptomics (ST) data to identify tissue structures with enrichment of disease-implicated genes = likely causal drivers of disease biology.
www.biorxiv.org/content/10.1...

Join us at the Nobel Symposium

Multiple Sclerosis: Past, Present and Future Treatment

June 5th, 2025 | Jacob Berzelius lecture hall @ki.se | Stockholm, Sweden

free registration at:

jirango.com/cview/web/f0...

#ReThinkNeuroimmunology
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/

Last day to apply to a PhD position in my lab - comparative epigenomic project focusing on development nad evolution of the human brain. Apply below 👇