Uppsala Antibiotic Center

New #TheAMRStudio episode out now!
🎙️ Prof. @tovefall.bsky.social on microbiomes, study design & following your passion & skills!
Plus: vaginal resistome & new β-lactamase inhibitors from our center!
🎧 Listen: episodes.fm/1441318864/e...

#AMR #Microbiome #Scicomm #epidemiology

Our coordinator sharing powerful messages about #antibioticresistance last night at #pint25 outreach festival.

Our first-ever UAC Career Day brought alumni + students together for real talk on life after the PhD.

From diagnostics to policy, public health to academia, every path was different, every insight valuable!

Grateful to all our speakers 💬
📎 Read the recap: bit.ly/careeruac25

#phdlife #AMR

Thank you guys for your work and efforts! Always cool insights coming out of your labs 🤗

🎙️Ep61 of #theAMRstudio is out!
Join us as we talk with Prof. Elias Arnér about his work in redox biology and the development of the novel antibiotic candidate, EbsArgent.

We also explore:
- Resistance of Ceftazidime-avibactam
- Mechanisms behind FusB-mediated resistance

www.uu.se/en/centre/up...

Today our PhD student and podcast host Elon Fermér is presenting her half time seminar, focusing on bridging #biofilms & #betalactam + betalactamase inhibitors. This work will be discussed with Erik Holmqvist, Helen Wang & Pål Jarle Jensen from @cansuit.bsky.social as committee.

So well said! Both encouraging because of the opportunities but so discouraging to see we are just not doing enough.

#ESCMIDGlobal

What if instead of vilifying over-the-counter #antibioticprescription we taught and educated those potential sellers? @marcmendelson.bsky.social holds the difficult position of arguing against #newantibiotics, but greatly highlights all other aspects that require our attention

#ESCMIDGlobal

Day 4 and still touching on new topics! Now #probiotics on the scene. Lena Biehl brings evidence of their use for different indications. What’s promising:
- use during (not before, not after!) #ab treatment to prevent diarrhea
- vaginal use for #UTI, #candidiasis & #vaginosis

#ESCMIDGlobal

515.000 deaths, 2.5billion antibiotic doses, and A LOT of money can be saved by vaccination. Mateusz Hasso from @who.int makes a case for widespread immunization to reduce #AMR burden.

Here’s the report: www.who.int/publications...

#ESCMIDGlobal

Vaccines are undoubtedly a way to manage #AMR, directly and indirectly! Adam Cunningham talks benefits and challenges.
Vaccination to both #bacteria & #viruses reduces infection, disease burden & #antibiotic use!

#ESCMIDGlobal

Fusariosis can be as scary as it sounds. Fungal infections might not be as common as bacterial, but when they do happen their #resistance patterns can look like this! 😱 Thanks to @olivercornely.bsky.social for bringing us the new #antifungals coming to the rescue!

#ESCMIDGlobal

4th day starts with the #antibiotic pipeline. New drugs for our bugs! Martin Emting develops synthetic antivirulence molecules, aka pathoblockers 🙅🏻‍♀️ These drugs can stop bacteria from infecting by targeting systems like quorum sensing (bacterial communication!).

#ESCMIDGlobal

Just made a custom feed that pulls in a wide array of hashtags being used at ESCMID Global 2025

May have a few minutes delay, but contains posts with
#ESCMIDGlobal #ESCMIDGlobal2025 #ESCMID2025 #ECCMID2025

Feel free to pin it to your timelines. Hope it's helpful #IDSky

bsky.app/profile/did:...

How to leverage #free-text data in GP health records? Gjis Danoe presents the BERT&EARNIE #AI driven #surveillance approach.
Model can pick up signals of early outbreaks!

Great potential for well organized #healthcare settings, where records are routinely gather!

#ESCMIDGlobal

Couldn’t agree more with @teachepi.bsky.social!

Communication is vital, essential, NEEDED for progress! #comms skills should be as important as any other lab skill for scientists, but specially for those working in topics that relate directly with the public

#ESCMIDGlobal

Final notes on how to address anti-science. Be open, take it seriously and TAKE ACTION!

#ESCMIDGlobal

How can we break the **really bad** #sciencenews cycle that ends undermining the power and value of scientific progress? We scientists can help on #scicomm part of it, but little power over click-bait journalism & internet spread. @phdcomics.bsky.social

phdcomics.com/comics/archi...

#ESCMIDGlobal

Listening to the great @marionkoopmans.bsky.social at a #ESCMIDGlobal session on #anti-science and trust in science.

The public seems to agree with scientists needing to communicate to general audiences, but not so clear when asked if they should advocate or influence #policy.

Why would this be?

The new frontier for them would be to have the #utilizerID and add the new #utilizerAST test which will provide answer to 3-5 antibiotics commonly used for UTIs

#ESCMIDGlobal

Emre Iseri from Utilizer present their method, based on a chromogenic agar on a dipstick, marrying the traditional culture method with the urine analysis tests. Easy, simple and quick to give results.

#ESCMIDGlobal

Patrice Nordmann brings us their cheap, easy & rapid test to detect #betalactamase activity in urine samples from #UTI patients. The test is based on Nitrocefin, which changes color if hydrolized when the enzymes are present. The hope is to bring it directly to the doctors office

#ESCMIDGlobal

In the wake of deploying new agents like new #metalobetalactamaseinhibitors, new tests look to find their usability from the get go, as resistance to these compounds can be already out there. Octavio Raro presents the NitroSpeed Taniborbactam platform based on hydrolization

#ESCMIDGlobal

Christian Moguet brings their lateral flow test to detect DHA AmpC #betalactamase in enterobacterales. Current work shows that the test has high sensitivity and can differentiate between low and high expression of the enzyme, which correlates with resistance phenotype

#ESCMIDGlobal

Starting the third day with #rapidAST. What’s new trying to get faster AND better? Julia Rogers presents a new lateral flow test that can detect the presence of an important betalactamase: KP2 #carbapenemase

Test like this would be incredibly helpful in low-resource settings!

The past, present and future? of #theAMRstudio podcast right before the #scicomm & #podcasting session at #ESCMIDGlobal

So great to see the inspiring stories of @idiots-pod.bsky.social & Breakpoints @erinmccreary.bsky.social, examples to follow!

Colleague Sheida Heidarian presenting her e-poster on #hereroresistance on #enterococcus.
Mainly found for gentamicin, daptomycin through point mutations & for tigecycline via gene amplification.

#ESCMIDGlobal

Patient-centric view of #uUTI at the GSK integrated symposium.
As a woman that has had recurrent UTIs in her youth, I love this take! I agree wholeheartedly with all these points, which can be reached if doctors would have more time for each patient!

Btw, pivmecillinam is THE BEST!

#ESCMIDGlobal

When normal traditional #phagetherapy via phage isolation proves to be difficult… is there other way? Panos Kalatzis presents a tripartite strategy that includes also lysis from prophages, and endolysins to target

#ESCMIDGlobal

How to treat a rather pesty microbe like #mycobacterium? Gregory Phelps brings us a phenicol prodrug with a new mechanism of action that exploits intrinsic resistance and that shows collateral sensitivity for standard of care drugs.

#ESCMIDGlobal