Ronan Broderick

Great to be back in Cambridge for this year's GSN. Some amazing talks and so great to reconnect with colleagues and to make new acquaintances.
#GSN #genomestability #chromatin #DNA

How DNA secondary structures drive replication fork instability DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…

Read our latest work - a comprehensive review on how DNA secondary structures affect replication.

Very proud of Adi, Maria and Billie for their monumental effort. They've covered a large body of literature while proposing updated models.

Open Access in DNA Repair:
doi.org/10.1016/j.dn...

Our researchers are decoding the ALT process—used by 10–15% of cancers to survive. With @unibirmingham.bsky.social #BlueBEAR HPC, long-read sequencing & deep learning, we aim to uncover therapeutic targets & biomarkers. #CancerResearch #Genomics #HPC blog.bham.ac.uk/bear/2025/11...

My lab at the University of Birmingham have a fully funded 4 year PhD position available, focusing on the molecular mechanisms of the Alternative Lengthening of Telomeres (ALT).

Informal enquiries to r.a.broderick@bham.ac.uk

APPLICATION LINK:
sits.bham.ac.uk/urd/sits.urd...

Upcoming genome biology conference in Birmingham featuring some excellent speakers- give it a look!

Congratulations 🎊

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair Garvin et al. find that the poorly explored SUMO isoform, SUMO4, enhances the deSUMOylation activity of the SUMO protease SENP1. Consequently, SUMO4 acts to restrain excessive cellular SUMOylation. In...

We are delighted to announce our first-ever BlueSky post – and the latest paper from our lab. with the Leney Lab @leneyms.bsky.social
dlvr.it/TJN3yl
@cp-molcell.bsky.social
@unibirmingham.bsky.social

Congratulations - really nice work!

Great work- congrats to all involved!

Congratulations to all involved!

Congratulations! Great to see this story published!

PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...

Happy to finally share this paper from our lab! First authors @kezlane.bsky.social @alison-harrod.bsky.social and the team worked so hard on it, I'm proud to be on it too!

PBAF as the protector of centromere and pericentromere integrity🧬🔬

@thedownslab.bsky.social
www.nature.com/articles/s41...

Still a few days left to apply! I'm recruiting for two Postdoc positions in my lab at the University of Birmingham, investigating the Alternative Lengthening of Telomeres.

Research Fellow at University of Birmingham Discover an exciting academic career path as a Research Fellow at jobs.ac.uk. Don't miss out on this job opportunity - apply today!

My lab is #hiring!

I am recruiting for two #Postdoc positions investigating the Alternative Lengthening of Telomeres mechanism.

www.jobs.ac.uk/job/DLO693/r...

www.jobs.ac.uk/job/DLP016/r...

#Telomere #DNAreplication #DNArepair #cancer #glioma #UKRI #MRC #universityofbirmingham #NGS

We are looking for a #Postdoc to join our team to work on a funded project by La Ligue investigating the role of #gut permeability as a cause of #cancer with #age. 🐟🐟🐟
#zebrafish #telomerase #microbiome DEADLINE: 29/Jan/2025
Please help us spread the word! 🙏

Delighted to join the University of Birmingham as a Research Fellow, supported by an MRC Career Development Award, establishing my own lab studying the Alternative Lengthening of Telomeres.

Watch this space for opportunities for post-doc positions in my lab!
#telomere #cancer #mrc #dnarepair #uob