Bryon Silva

Congrats Jaime :) (totalmente merecido!)

meaning, neuromodulators and glia put whole compartments into a high energy learning state, but only the activated KC synapses in that compartment undergo lasting plasticity

very honestly, I don’t think we know yet how tight the spatial match is between this energetic state and the actual memory trace. I think learning in the MB is globally/metabolically enabled but locally written

thanks a lot, Cahir, really nice question and something I’ve been thinking about too. I think the metabolic pathways we monitor here are not confined to the tiny subset of odor activated KC/MBON synapses that are actually modified, but reflect a broader “MB in learning mode” state

Thank you :), if only it worked like that 😅 would be amazing!
I think the fat these memory neurons burn is tiny compared with whole body metabolism so I would say no weight loss hack yet, just a cool brain energy trick for now ;)

thank you :)

Discovery of Neuronal Fatty Acid Oxidation in vivo Intensive learning in Drosophila relies on neuronal fatty acid oxidation. This discovery overturns the long-held view that adult neurons do not use fat as fuel.

Ten years in the making. For the full story behind the data, read the "Behind the Paper" piece 😉

Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...

Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation.

Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com

Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway - Nature Neuroscience Buron et al. show that oxytocin enhances heart rate variability linked to breathing during recovery from stress. This calming and cardio-protective effect is produced through a hypothalamus–brainstem ...

Cool cool cool!

Induction of menstruation in mice reveals the regulation of menstrual shedding During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

under construction... 😶‍🌫️

oh thank you! :)

This is really fantastic, whenever an old dogma is broken is worth highlighting it as one of the key papers of the year :)!
Congratulations, I have been following this article since it was posted on biorxiv, very huge contribution to the metabolism field 💪

A restricted subset of gut-innervating neurons that express the neuropeptide myosuppressin (Ms) innervate the crop, a stomach-like structure of the fly intestine. This figure shows co-expression between the Ms protein reporter (green) and Ms peptide (red) in the nervous system, and in neuronal projections towards the gut (blue).

If you find yourself at @edrc2025.bsky.social please check my wonderful postdoc's talk @neurogut.bsky.social at the gut workshop this afternoon. Gut, sex, reproduction, our new story! In combo with @irenemiguel-aliaga.bsky.social! @fly-jedi.bsky.social #EDRC2025

🫶

Thank you Jose, I'm glad you enjoyed it :)

A fantastic way of imaging lipids!

Dual-cycle CO2 fixation enhances growth and lipid synthesis in Arabidopsis thaliana Carbon fixation through the Calvin-Benson-Bassham (CBB) cycle accounts for the majority of carbon dioxide (CO2) uptake from the atmosphere. The CBB cycle generates C3 carbohydrates but is inefficient ...

Dual-cycle CO2 fixation enhances growth and lipid synthesis in Arabidopsis thaliana | Science www.science.org/doi/10.1126/...
Woooooow

In 2022, I had the honor of publishing this paper as the cover of Nature Metabolism. We uncovered a glia-to-neuron ketone body shuttle (reminiscent of the ANLS model) that shaped my work on neuronal energy metabolism. It is rewarding to see these findings now inspiring questions across many fields

Glia feed neurons upon starvation: our 2022 Nature Metabolism paper revealed a glia-to-neuron ketone body shuttle 💪
#Memories #EnergyMetabolism #Glia @naturemetabolism.bsky.social ky.social

www.nature.com/articles/s42...

Good job :)

you see @drosostalis.bsky.social the peanut butter texture was just my innate talent 😜

Quantitative imaging of lipid transport in mammalian cells - Nature Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

This is awesome! Lipid probes for quantitative imaging of lipid transport. A real need in the lipid field!

@nadlerlab.bsky.social

I am ready :)