María Fernández-Casañas

DNA2 enables growth by restricting recombination-restarted replication - Nature DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

03.09.2025 15:59 — 👍 39    🔁 19    💬 7    📌 1

Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication Genome inheritance during cell divisions relies on replicated sister DNAs being connected by cohesin rings. Minamino et al. reconstitute sister chromatid cohesion establishment during DNA replication using purified budding yeast proteins. The experiments yield molecular insight into more than one way in which sister chromatid cohesion can be built.

Online Now: Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication Online now:

16.09.2025 15:20 — 👍 9    🔁 7    💬 0    📌 0

Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs

www.cell.com/cell-reports...

16.09.2025 15:30 — 👍 14    🔁 7    💬 0    📌 1

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...

Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

01.09.2025 10:04 — 👍 30    🔁 15    💬 2    📌 0

A fantastic week of science (and nature) at the CSHL Eukaryotic DNA Replication & Genome Maintenance meeting ! #cshldnarep

07.09.2025 19:18 — 👍 6    🔁 1    💬 0    📌 0

Genome Centre throughout the years! @gdsc-sussex.bsky.social #GDSC #Brighton #ArchiveShot

05.09.2025 21:53 — 👍 2    🔁 1    💬 0    📌 1

Thank you, Uli! Really appreciate your support and all the insightful discussions throughout this project!

05.09.2025 19:50 — 👍 0    🔁 0    💬 0    📌 0

Thanks Tony! Always a pleasure collaborating with you!

01.09.2025 07:01 — 👍 1    🔁 0    💬 0    📌 0

So pleased to see my PhD project published, great work by everyone involved! Together we uncovered how regulation of the BTRR complex is crucial to protect centromeres during mitosis.

01.09.2025 06:58 — 👍 5    🔁 1    💬 0    📌 1

Looking forward to the next Helicase Conference! #HelicasesandNucleicAcidBasedMachines #Lisboa2025

07.07.2025 14:14 — 👍 8    🔁 2    💬 2    📌 0

Great to be at the Helicase Conference in Lisbon this week! 🧬
#HelicasesandNucleicAcidBasedMachines #CentroDeCongressos #Lisboa2025 #Unwinding @costerlab.bsky.social

29.06.2025 20:48 — 👍 2    🔁 0    💬 0    📌 0

New lab member joining is a great excuse to eat out and take a new lab photo 🎉🍜📷

12.06.2025 14:27 — 👍 9    🔁 2    💬 0    📌 0