Mariem Radhouani

A big thank you to the ÖGAI for this recognition and for supporting young scientists in Austria and of course to my PI @philippstarkl.bsky.social, all our colleagues and collaborators that made this project possible! ☺️

🏆 Honored to receive the Clemens von Pirquet Prize from the ÖGAI a few days ago for my 1st author paper in SciImm!
🎓 A perfect way to wrap up my PhD @starkllab.bsky.social & say goodbye to 🇦🇹 before starting my postdoc in 🇧🇪

🔗 doi.org/10.1126/scii...
@science.org @meduniwien.ac.at @cemm.oeaw.ac.at

I have finally wrapped up my PhD! 👩🏾‍🎓
It’s been a long road filled with challenges, a LOT of learning & fun!
So proud to be the first PhD from @starkllab.bsky.social, and really thankful to @philippstarkl.bsky.social for his support, trust & guidance.
Grateful to everyone who helped me along the way 🩷

OBS SPEAKER HIGHLIGHT👩‍🔬
How Skin Injury Primes Distant Immunity
🗣️ @mariemradhouani.bsky.social
@starkllab.bsky.social lab.bsky.social
@cemm-vienna.bsky.social @meduniwien.ac.at

📆 Thu, June 5, 11 pm ET
👉 Registration:
us02web.zoom.us/meeting/regi...

🔬 OBS Immunology Seminar

🗣️ @mariemradhouani.bsky.social l @starkllab.bsky.social lab.bsky.social @meduniwien.ac.at @cemm-vienna.bsky.social
🗣️Daniel A. Waizman Andrew Wang Lab
@yalemedicine.bsky.social

🗓️ Thu, June 5th, 11 pm ET
👇
us02web.zoom.us/meeting/regi...

YouTube video by MedUni Wien 60 Seconds of Science! Skin infections can increase lung allergies

Grateful to have my research featured in #60SecondsOfScience series by @meduniwien.ac.at!
In 1 min ⏱️, I share how skin infections can shape allergic responses in lungs.
Excited to share my work in such a creative and accessible way!💡
🔗 youtu.be/ltCHBo7Pw0M?...

#SciComm #Immunology #PhD #Allergy

@cemm-vienna.bsky.social

Fachleute finden Faktor, der Allergien verstärken kann Ein Team der Med-Uni Wien entdeckte bei Mäusen einen Zusammenhang zwischen bakteriellen Infektionen der Haut und Krankheiten wie allergischem Asthma

"Making national news" definitely wasn't on my PhD bingo card - but here we are!
What an honor that @derstandard.at covered our most recent findings:
www.derstandard.at/story/300000...

Link to the study: www.science.org/doi/10.1126/...

@starkllab.bsky.social

#scicomm #PhDlife

Thank you so much Helena! :)

Thank you for sharing our work! ☺️

9/9 I'd love to connect if you're interested in trained immunity, eosinophils, allergy, or infection-driven inflammation @science.org
#ScienceImmunology #PhDResearch #TrainedImmunity #Eosinophils #Asthma #Allergy #SkinInfection

8/9 Huge thanks to my supervisor @philippstarkl.bsky.social , our team at MedUni Vienna, CeMM, and all collaborators for making this work possible and this incredible journey! Here on bsky @asmafarhat.bsky.social @vojtechdvorak.bsky.social @andysombke.bsky.social @nikfortelny.bsky.social

7/9 These results uncover a novel skin–bone marrow–lung axis in immunity and help explain how local infections can have systemic and long-term effects on allergic inflammation.

6/9 Importantly, pharmacological blockade of IL-33 or C5a attenuated the inflammation, suggesting potential therapeutic targets in trained eosinophil-mediated allergic disease.

5/9 Mechanistically, IL-33 promoted eosinophil expansion in the bone marrow, while C5a guided their recruitment to the lungs. Eosinophils directly sensed both signals via ST2 and C5aR1 receptors.

4/9 This immune imprinting persisted beyond bacterial clearance, transferred to naïve mice via bone marrow transplantation, and was eosinophil-specific as shown by adoptive eosinophil transfer.

3/9 Upon later allergen exposure (house dust mite), these trained eosinophils drove stronger type 2 inflammation in the lungs, including increased eosinophilia, proinflammatory cytokines, allergen-specific antibodies, and impaired lung function.

2/9 This work, done in @starkllab.bsky.social , shows that the infection reprograms eosinophils both transcriptionally and epigenetically, also shifting their metabolism and functional behaviour - all hallmarks of innate immune memory.

Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation Staphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation.

I'm excited to share my first-author PhD paper, now out in Science Immunology! @science.org
We show that S.aureus skin infection leaves a lasting imprint on bone marrow eosinophils, fueling allergic responses in the lungs.
📄 Read the full study: www.science.org/doi/10.1126/...
Let’s dive in 🧵 1/9

Very cool (and surreal!) seeing my paper featured on the Science homepage www.science.org !! #ScienceImmunology
science.org/doi/10.1126/sciimmunol.adk5041

Amazing!!! 🤩

Huge congrats to @asmafarhat.bsky.social who spearheaded this fantastic work - now out in Science Immunology 🥳

It was a pleasure being part of the team and I'm proud to be second author on this great study🙌

👇 Check out her thread for the full story!