Georg Winter

Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Nature Chemistry In targeted protein degradation, a degrader molecule brings a neosubstrate protein proximal to a hijacked E3 ligase for its ubiquitination. Here, pseudo-natural products derived from (−)-myrtanol—iDeg...

paper alert🚨
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Published by the groups of Herbert Waldmann @waldido.bsky.social , Slava Ziegler and @georgwinter.bsky.social @cemm.oeaw.ac.at in @nature.com Chemistry
www.nature.com/articles/s41...

Flagging a cool funding opportunity closing soon: AITHYRA Global Collaborator! $150k/year to tackle AI × biomedicine grand challenges. Shame there’s no plant science angle—but we’ll forgive them for now 😉! @georgwinter.bsky.social @mmbronstein.bsky.social @aithyra.bsky.social

congrats, Alex

Inhibitors supercharge kinase turnover through native proteolytic circuits - Nature Inhibitor-induced kinase degradation is a common event that positions supercharging of endogenous degradation circuits as an alternative to classical proximity-inducing degraders.

Excited to share our work on inhibitors turning degraders now out: doi.org/10.1038/s415...

Georg Winter and first author Natalie Scholes (c) Barbara Bachmann/CeMM

New Study published in Nature by the group of @georgwinter.bsky.social, From Inhibition to Destruction - Kinase Drugs Found to Trigger Protein Degradation aithyra.at/news/ #AITHYRA #CeMM #TPD

POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004 The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

Was wonderful presenting at the #AITHYRA AI for Life Science Opening Symposium in Vienna this week! Thank you @mmbronstein.bsky.social and @georgwinter.bsky.social for the invitation to present our newest work! #biology #research #AIforLifeScience @imbavienna.bsky.social @francesarnold.bsky.social

We are honored that Nobel laureate @francesarnold.bsky.social of @caltech.edu is giving the keynote lecture tonight at the #AIforLifeScience Symposium!

“We need to start all over again and reinvent small molecule drug discovery in a way that is native to AI”, Greg Verdine, Co-Founder, President and CEO of LifeMine Therapeutics, is convinced. #AIForLifeScience #AITHYRA

“We can do science in a different way: generate very big datasets, train models with them, and then use that to predict and engineer biology”, says @benlehner.bsky.social from @sangerinstitute.bsky.social at the #AITHYRA #AIForLifeScience Symposium

AITHYRA #AIinLifeScience Symposium Participants (c) Bubu Dujmic

Everything comes to an end, but we have the feeling that the first AITHYRA #AIinLifeScience Symposium in Vienna can only be the beginning of a conference series. Thanks to all participants for a successful event! www.oeaw.ac.at/aithyra/about

🎉 Celebrating 5 years of CeMM #SpinOffs Proxygen & Solgate!

From molecular glue degraders to solute carriers, both companies show how basic research can drive #biotech innovation & have a real impact for patients.

🔎 Learn more about their scientific journey & research: https://bit.ly/4pdIl7N

Xinyi Zhang = curious + adventurous + collaborative + nature-loving + pilot

With great pleasure we announce that XINYI ZHANG is one of the Starting PIs AI/LS who will join AITHYRA. Xinyi will develop machine learning models for cell and tissue biology: from multimodal integration to biomarkers and function.

More info: www.oeaw.ac.at/aithyra/rese...
#AITHYRA #StartingPI

Apply for the AITHYRA-CeMM International PhD Program!

15-20 fully funded PhD fellowships available in Vienna, AT
in AI/ML and Life Sciences

Deadline for applications:
10 September 2025 apply.cemm.at

@aithyra.bsky.social Opening Symposium "AI for Life Science" with Nobel Laureate Frances Arnold as keynote speaker in addition to an outstanding line up of speakers on a variety of topics across biological scales and data modalities.

Registration is now open at cemm.at/aithyra-symp...

We are searching for an AI researcher in lab automation, statistical ML and (theoretical) physics AI for bio/med. Expression of interest and nominations welcome!!!

New #EquationsForLife at #CeMM! Discover how the @georgwinter.bsky.social's lab pioneers #TDP. By modeling interactions between degraders & binding partners, their chosen #HillEquation helps them optimize degrader design to eliminate disease-relevant proteins precisely.
🔎 tinyurl.com/CeMMRR2024-W...

- Mutations mimicking glues by @brianliau.bsky.social al and Ning Zheng
- Covalent and bivalent glue engagement by @dannomura.bsky.social, Nathanael Gray, @georgwinter.bsky.social and @alessiociulli.bsky.social
- And finish it of with a discussion on general mode-of-action.

Happy AITHYRA Directors Anita Ender, Michael Bronstein and Georg Winter with an optimistic view into the future (c) Natascha Unkart.jpg

Thank you to many Starting PI candidates who showed their interest in joining #AITHYRA. We will need a few weeks to go over the applications with our hiring committee, but will come back to you asap. The PI hearing is planned to take place in Vienna, mid of June. 👐

Please save-the-date for the #AITHYRA Symposium “AI for Life Science”, which will take place in Vienna at the House of Industry from 8-10 September 2025. Great speakers, interesting framework programme and beautiful location. Registration will open mid May. More info: www.oeaw.ac.at/aithyra/news...

Join us in Vienna on Sep 8-10 with an incredible speaker lineup!

A reminder that @aithyra.bsky.social has an open call for starting PIs. We offer some of the best conditions in Europe rivalling MP and ETHZ

www.oeaw.ac.at/aithyra/news...

Deadline is tomorrow!

Targeted protein degradation for cancer therapy - Nature Reviews Cancer Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. In this Review, Hinterndorfer et al. outline the mechanistic bases of TPD and discuss the characteristics, advantages and applications of established compounds as well as upcoming classes of degraders.

REVIEW 🚨

Targeted protein degradation (TPD) is an emerging pharmacological modality in cancer therapy. Here, Winter + colleagues, outline the mechanistic bases of TPD and outline both established + upcoming classes of degraders.

📖 👇

Please welcome AITHYRA, the Research Institute for Artificial Intelligence of the Austrian Academy of Science on social media. Follow us and connect via Bluesky and LinkedIn 👋

Hello, we are AITHYRA!
I am very excited to share with you the corporate identity of AITHYRA, the Research Institute for Biomedical AI.

Check out the brand design video (sound on!) to learn more.

**REMINDER**
One week left to apply for Starting PI positions (Life Science and AI/ML). Come join us!

🚨 Hiring Alert – Senior Scientist (Biology) 🚨
My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology
🧬 Lead screens
🤝 Collaborate with top-tier AI/chemistry/biology minds

Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz

Search for LIFE SCIENCE and AI/ML Starting Principal Investigators (m/f/d) at AITHYRA, Vienna If you are an ambitious early-career scientist ready to propel your research to new heights, we invite you to be part of AITHYRA’s founding generation of Principal Investigators. Together, we will sha...

Aithyra is hiring! We are looking for multiple starting PIs in life sciences and AI/ML. We offer highly competitive packages and salaries among the highest in Europe.

www.oeaw.ac.at/aithyra/news...

Thanks a lot, Anna. Looking forward to having your as neighbor and source of inspiration!

Thanks, Christa!