Ilana Bennett

Identifying a proteomics signature of cognitive impairment and dementia in blood and cerebrospinal fluid through a mediation analysis framework This study aimed to identify CSF and plasma proteins that mediate the association between age and mild cognitive impairment (MCI) and Alzheimer’s dise…

✨ SHINY NEW PAPER ✨

Across 3 datasets (3000+ participants), GFAP in both CSF and plasma consistently mediated the effect of age on cognitive impairment and dementia (MCI/AD incidence)

www.sciencedirect.com/science/arti...

Targeting neuronal activity and neuroinflammation for the treatment of Alzheimer’s disease in a mouse model Alzheimer’s disease (AD) is characterized by progressive cognitive decline driven by complex pathological processes, including tau hyperphosphorylatio…

✨ SHINY NEW PAPER ✨

Treatments targeting inflammation (DHCA) and neuronal activity (Mal-gluc) significantly improved recognition memory in 3xTg-AD mice, but did not reduce p-Tau or Aβ burden

www.sciencedirect.com/science/arti...

Hippocampal 1H-MR spectroscopy metabolites are linked to CSF tau pathology in cognitively unimpaired older adults along the Alzheimer’s continuum Relationships between Alzheimer’s disease (AD) pathologies in cognitively unimpaired adults and in vivo neurometabolic properties measured directly fr…

✨ SHINY NEW PAPER ✨

Tau relates to MR spectroscopy estimates of N-acetylaspartate and myo-inositol in cognitively-unimpaired amyloid-positive adults

@elizabethhead.bsky.social

www.sciencedirect.com/science/arti...

Most Alzheimer’s cases linked to variants in a single gene Potentially more than 90% of Alzheimer’s disease cases would not occur without the contribution of a single gene (APOE), according to a new analysis led by UCL researchers.

Most Alzheimer’s cases linked to variants in a single gene ucl.ac.uk/news/2026/ja... by @ucl.ac.uk

#Alzheimers #dementia #science #neuroscience #NeuroSkyence

📚 NEW ISSUE 📚

Articles cover age-related structural differences in the fischer brown Norway rat and bonnet macaques, apraxis deficis in Alzheimer's Disease, proteomic markers of aging, and more.

www.sciencedirect.com/journal/neur...

Microstructural changes in locus coeruleus-cortical projections in aged bonnet macaques are independent of myelin loss The locus coeruleus (LC) is a brainstem nucleus best known for being the primary site of noradrenaline production for the forebrain and is involved in…

✨ SHINY NEW PAPER ✨

MRI-based diffusion metrics are higher in aged macaques in the central tegmental tract, an ascending projection from the locus coeruleus

www.sciencedirect.com/science/arti...

Cerebral small-vessel disease severity, hypertension, and body mass index forecast striatal dopamine D2-receptor decline rates in aging Normal aging is associated with decline in dopamine function. Factors associated with individual differences in dopamine decline rates remain unclear …

✨ SHINY NEW PAPER ✨

Markers of cerebral small-vessel disease (white-matter lesions, lacunes) and vascular risk (e.g., hypertension, BMI) relate to faster 5-year decline in striatal dopamine (DRD2)

@lipmpib.bsky.social

www.sciencedirect.com/science/arti...

High estimated pulse-wave velocity is associated with lower brain white matter microstructural integrity twelve years later High pulse wave velocity (PWV), a measure of increased arterial stiffness, is a risk factor for cerebrovascular disease. PWV can be estimated (ePWV) f…

✨SHINY NEW PAPER ✨

Higher pulse wave velocity is associated with white matter microstructural damage in older adults 12 years later

www.sciencedirect.com/science/arti...

Repeated brain MRI utility in identifying neurodegenerative disorders at the pre-dementia stage Despite the increasing availability of biomarkers in clinical settings, diagnosing individuals with subtle cognitive/behavioral symptoms and normal st…

✨ SHINY NEW PAPER ✨

Repeated MRI measures of brain volume can help detect later conversion to AD/FTD

www.sciencedirect.com/science/article/pii/S0197458025001265

📚 NEW ISSUE 📚

Articles cover pulse-wave velocity, cerebral small vessel disease, choroid plexus volume, hearing loss, and racial discrimination in aging, and more.

www.sciencedirect.com/journal/neurobiology-of-aging/vol/156/suppl/C

Integrating plasma, MRI, and cognitive biomarkers for personalized prediction of decline across cognitive domains Plasma biomarkers are associated with cognitive performance and decline in Alzheimer’s disease, making them promising for early detection. This study …

✨ SHINY NEW PAPER ✨

MRI-derived regional volume and thickness are stronger predictors of cognitive decline, especially for memory, but plasma biomarkers do add predictive value

www.sciencedirect.com/science/article/pii/S0197458025001137

White matter hyperintensities contribute to early cortical thinning in addition to tau in aging White matter hyperintensities (WMH) are associated with cortical thinning in distant brain regions. However, it is currently unclear how WMH affect ne…

✨ SHINY NEW PAPER ✨

WMH in the temporal lobe relate to early cortical thinning in AD, beyond what is expected due to amyloid and tau

@leoriki3.bsky.social @compneurology.bsky.social

www.sciencedirect.com/science/article/pii/S0197458025001216

Blood oxygenation level-dependent responses in neuromodulatory nuclei and their associations with attention and memory across age groups Using multi-echo blood oxygenation level-dependent (BOLD) neuroimaging, we examined lifespan differences in three subcortical nuclei important to the …

✨ SHINY NEW PAPER ✨

BOLD in LC related to subsequent memory performance in adults across the lifespan, possibly due to attentional boosting of memory

www.sciencedirect.com/science/article/pii/S019745802500123X

Comparison of CSF neurofilament light chain and total tau as neurodegeneration markers: Associations with synaptic markers and cognitive outcomes Clinically, Alzheimer's disease (AD) is characterized by progressive cognitive decline due to neuronal and synaptic degeneration. Neurofilament light …

✨ SHINY NEW PAPER ✨

T-tau, a marker or gray matter degeneration, is more strongly correlated with synaptic biomarkers (neurogranin and BACE1) than NfL

www.sciencedirect.com/science/article/pii/S0197458025001198

New paper in Imaging Neuroscience by Adam Kimbler & Craig E.L. Stark:

Advanced diffusion imaging in grey matter reflects individual differences in cognitive ability in older adults

doi.org/10.1162/IMAG...

📚 NEW ISSUE 📚

Articles cover epigenetic and brain aging, plasma and MRI predictors of cognition in aging, aging of hippocampal microstructure, and more.

www.sciencedirect.com/journal/neurobiology-of-aging/vol/155/suppl/C

Neurobiological effects of exergame interventions in older adults with or without a neurocognitive disorder: A systematic review Exergames (EG) are interactive video games that require physical activity and use gamification to make exercise more engaging. EG interventions demons…

✨ SHINY NEW PAPER ✨

Interactive video games that make exercise more engaging can change brain structure and function in older adults.

www.sciencedirect.com/science/article/pii/S019745802500106X

📣 One more month to submit to this Special Issue on Brain Resilience & Diversity in Aging and Dementia!

@mnrajah.bsky.social

Evaluating the link between hearing loss and Alzheimer’s disease neuropathology: A systematic review and meta-analysis Hearing loss has been linked with cognitive decline and increased dementia risk. The neurobiological mechanisms underlying this relationship are not c…

✨ SHINY NEW PAPER ✨

Hearing loss is more strongly associated with tau burden than β-amyloid (Aβ) burden.

@charlesmarshall.bsky.social

www.sciencedirect.com/science/article/pii/S0197458025001162

The Computational and Cognitive Neural Sciences lab (ballardlab.org) at UC Riverside is recruiting psychology PhD students to join our team! Check out the flyer to learn about the lab and our stellar research community at UCR. Apply by 12/1!
drive.google.com/file/d/19m8i...

Identifying lifestyle risk factors that discriminate memory trajectories: Differential findings across racial and ethnic groups in older adults Differences in lifestyle factors contribute towards inequalities in dementia incidence and memory trajectories across racial and ethnic groups. We ide…

✨ SHINY NEW PAPER ✨

Lifestyle risk factors can discriminate latent classes of memory trajectories but differ across racial-ethnic groups.

@profrwhitmer.bsky.social

www.sciencedirect.com/science/article/pii/S0197458025001174

Balance training improves postural control and performance-related prefrontal brain activation in healthy older adults: Results of a six-month randomized controlled training intervention Age-related deterioration in postural control is an important factor decreasing quality of life. Functional neuroimaging studies have shown that the a…

✨ SHINY NEW PAPER ✨

A 6-month balance training intervention improves postural control and performance-related prefrontal brain activation in older adults.

www.sciencedirect.com/science/article/pii/S0197458025001150

One last reminder that I’m recruiting a graduate student through the Cognition & Neural Science area @utah.edu this Fall! The lab uses MRI to study healthy cognitive aging across the adult lifespan and will start assessing factors that moderate cognitive aging (air pollution, cardiovascular health).

Two-year changes in hippocampal subfield volumes are age-dependent across the lifespan The hippocampus (Hc), which is crucial for memory across the lifespan, is comprised of distinct subfields: dentate gyrus (DG), Cornu Ammonis (CA) sect…

✨ SHINY NEW PAPER ✨

Hippocampal subfield volumes follow nonlinear trajectories across the lifespan.

@dranadaugherty.bsky.social @noaofen.bsky.social

www.sciencedirect.com/science/article/pii/S0197458025001149

Age-related differences in cerebral morphology and microstructure in rhesus macaques The rhesus macaque presents a promising model for translational research into human brain aging due to this species’ long lifespan and close phylogeni…

✨ SHINY NEW PAPER ✨

Cortico-striatal gray matter atrophy and white matter microstructural degradation across the rhesus macaque adult lifespan.

@dralisonweiss.bsky.social

www.sciencedirect.com/science/article/pii/S0197458025001010

How is self-reported sleep-disordered breathing linked with biomarkers of Alzheimer’s disease? Sleep-disordered breathing (SDB) is prevalent in Alzheimer’s disease (AD). Here, we assessed how self-reported SDB is linked with AD biomarkers, inclu…

✨ SHINY NEW PAPER ✨

Sleep-disordered breathing is associated with higher Aβ burden, lower rFDG, and worse cognition in Alzheimer's Disease.

@sbe.bsky.social

www.sciencedirect.com/science/article/pii/S0197458025001034

Effects of age on the strategic control of recollected content as reflected by modulation of neural correlates of scene retrieval A previous study employing fMRI measures of retrieval-related neural selectivity reported that young, but not older, adults employ ‘retrieval gating’ …

✨ SHINY NEW PAPER ✨

Older adults fail to gate irrelevant information, indicating a top-down inhibitory control deficit that controbutes to their worse memory.

www.sciencedirect.com/science/arti...

@fnim-lab.bsky.social

Exciting news! 🎉 Our Computational Neuroscience course has been awarded NIH BRAIN Initiative funding! Students will get hands-on experience w real BRAIN Initiative datasets, helping them build computational skills that are essential for the future of neuroscience.

www.linkedin.com/feed/update/...

📚 NEW ISSUE 📚

Articles cover effects of age on brain structure, balance training, exergame interventions, links between hearing loss and AD, and more.

www.sciencedirect.com/journal/neurobiology-of-aging/vol/154/suppl/C

Biological age acceleration in Alzheimer’s disease modulates relative cortical to medial temporal lobe neurodegeneration Alzheimer’s disease (AD) is highly associated with aging, typically presenting with amnestic, multi-domain cognitive impairment and greater medial tem…

✨ SHINY NEW PAPER ✨

Atypical presentation of AD with greater cortical involvement is seen in individuals with younger chronological age or younger biological age relative to their chronological age.

www.sciencedirect.com/science/arti...

‪@patch-lab-upenn.bsky.social‬