Badr Sokrat

Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia | PNAS Although many internalized G protein-coupled receptors (GPCRs) continue to signal, the mechanisms and outcomes of intracellular GPCR signaling are ...

Excited to share Bunnett lab's work on targeting compartmentalized GPCR signaling! Using endosome-accumulating nanoparticles, they selectively blocked intracellular PAR2, achieving complete, long-lasting pain relief in inflammatory disease models.
www.pnas.org/doi/10.1073/...

13.10.2025 17:52 — 👍 6    🔁 1    💬 1    📌 0

@nyupainresearch.bsky.social

02.06.2025 20:06 — 👍 1    🔁 0    💬 1    📌 0

Excited to share that I participated in the Annual Molecular Pathobiology Innovative Research Symposium at NYU and received an award for my flash talk presentation:
“Compartmentalized intracellular signaling of the prostaglandin EP4 receptor contributes to pain.”
#research #GPCR #pain #science

02.06.2025 20:05 — 👍 3    🔁 0    💬 1    📌 0

PRC Journal Club! #FlashbackFridays Flash back to earlier this week to a really interesting discussion led by @badrsokrat.bsky.social on endosomal signaling in opioid receptors. Click the article below to join the discussion. www.biorxiv.org/content/10.1...

11.04.2025 20:54 — 👍 6    🔁 3    💬 1    📌 0

PRC Highlight: Thank you to the Molecular Pathobiology for hosting the Birthday Tea Time #Partaayyy! Happy Birthday 🎉🎁🎈🎊🎂 @taeseonwoo.bsky.social @badrsokrat.bsky.social @tonelloraquel.bsky.social !!! #PRC #Painresearchcenter #boomerang ☕️🫖

27.02.2025 20:38 — 👍 12    🔁 4    💬 1    📌 0