Chalystha Lee

👉 We generated a starter pack for #neurogastroenterology and enteric #neuroscience!

Let's connect and bring gut-brain research and clinical neurogastroenterology to the next level! 🌐

go.bsky.app/3Z82PbH

The Margolis Lab had a great time at #ANMS2025 in Minneapolis! Postdocs Sarah, Lin & Chalystha gave abstract talks, PRC Director Kara closed the conference, and we met Keynote Speaker & 2021 Nobel Laureate David Julius and his team! #ANMS225

PRC Highlight: #MargolisLab making strides again! Congrats to Chalystha Lee who received the 2025 ISSR Travel Award at the #ISSR2025 hosted in Vienna! With mentorship from Dr. Kara Margolis & Dr. Michael Gershon lighting the way. #mentorship #ISSR #womeninresearch @chalysthalee.bsky.social

Alt text (expanded version for web or accessibility-focused platforms): Vertical infographic titled “Why Gabapentin Works Differently for Different People.” Section 1 explains that 10% of adults live with neuropathic pain and gabapentin doesn't help everyone. Section 2 shows that researchers used donated human dorsal root ganglia (DRG) neurons to study gabapentin’s effects, combining electrophysiology and RNA sequencing. Section 3 illustrates how gabapentin reduced excitability in some donors’ neurons but not others, and those differences matched gene expression profiles. Section 4 highlights how this could lead to more personalized pain treatment that adds life to the years of people living with chronic pain. Footer credits the donors and includes the study DOI

Gabapentin is widely prescribed for nerve pain, but it doesn’t work the same for everyone.

We studied actual human sensory neurons from donors and found that some responded strongly - and others hardly at all.
#fromlabtolife #neuroskyence #PainResearch 1/4

@margolislabnyu.bsky.social @nyupainresearch.bsky.social

Just back from a great week in Vienna for #ISSR2025. I am grateful for the travel award and the opportunity to share my work. Big thanks to @karapedsgastrodoc.bsky.social and Mike Gershon for their steady support in the lab and my career. Loved connecting with 5-HT researchers from around the world!

#ISSR2025

@karapedsgastrodoc.bsky.social gave a fantastic talk on the lab's important work on SSRI use in the gastrointestinal tract
@margolislabnyu.bsky.social highlighting @linyhung.bsky.social and @sarahanajjar.bsky.social 's work!
@nyupainresearch.bsky.social

Excited to learn about all things Serotonin / 5HT at #ISSR2025 in Vienna!

What do you think these #painresearch results from Ullrich et al. in Science Advances may mean for finding the patterns behind ligand bias? bit.ly/4elhYYE

And just like that, AMPIRS takes its final bow! 🎬Huge cheers to our grand finale presenters and a confetti cannon 🎉 of congrats to all the Flash Talk, Poster and Oral Presentation champs! 🏆 You dazzled, you delivered, you definitely deserve it! #PRCpride #MPBpride

Congratulations @tonelloraquel.bsky.social and @mariafialho.bsky.social !! Fantastic work!

Congratulations @sarahanajjar.bsky.social & @linyhung.bsky.social !! 🙌🥳

Aging and injury drive neuronal senescence in the dorsal root ganglia - Nature Neuroscience The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.

BOOM! www.nature.com/articles/s41... I think this is a big step forward for the field. Congrats to Lauren Donovan and @vivtawfik-mdphd.bsky.social and the whole Tawfik lab team.

I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...

🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱.
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...

Meet our 2025 AGA Council section leaders Introducing the five members elected to join the AGA Institute Council and lead specialty-based sections.

Congrats to @karapedsgastrodoc.bsky.social on becoming part of the 2025 AGA Council section leaders!! Read more👉 gastro.org/news/meet-ou...

Definitely something important to consider wrt our studies in rodent preclinical models!

🔬 Exciting discovery! We've been curious about the function of unique IBA1+ cell staining we observed around healthy human DRG neurons in the lab (indicated by red arrows). A new paper @cellpress.bsky.social finally provides some answers. Link: www.cell.com/cell/fulltex...

Well done, Woo-Tae! 🙌

We have slots for 2-3 postbacs! Get in touch if you’re interested in joining the Affective Neuroscience and Pain lab & contributing to our studies of pain, emotion, and social processing in the 🧠

last day to apply for a post-doc position in my group #phagesky #microsky

Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord - Nature Neuroscience Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...

How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study.

www.nature.com/articles/s41...

CONGRATULATIONS to Drs. Sarah Najjar, Lin Hung and Kara Margolis- Their review article: Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation is one of the top 10 most cited articles published in 2023! onlinelibrary.wiley.com/doi/abs/10.100… 🥳🔝🔟

Our program manager extraordinaire, Ayesha Ahmad, is leaving us, so we have an exciting position open to take on her role. jobs.utdallas.edu/postings/28956 In addition to this being an exciting position, you will also get to learn from Ayesha before she departs.

Looking for an excellent & highly motivated postdoctoral researcher to join our team to develop an exciting project focused on the generation of beneficial Innate Lymphoid Cells #ILC for the treatment of Inflammatory Bowel Disease #IBD using #organoids. Please share!
www.kcl.ac.uk/jobs/109186-...

So excited to share what I've been up to in the past year at the 2025 Serotonin Meeting in Vienna! Can't wait for July! Thank you ISSR for this travel grant! @margolislabnyu.bsky.social

Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid - Nature Microbiology Intestinal crypt-resident Acinetobacter radioresistens secretes indole acetic acid which activates an Ahr-Wnt-β-catenin-EphB2 signalling axis to promote intestinal stem cell homeostasis and prevent tu...

#GastroEdPick Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid @naturemicrobiol.bsky.social www.nature.com/articles/s41...

🎉 Celebrating Mike Gershon, the father of Neurogastroenterology and an amazing mentor! 🧠💡
Happy Birthday, Mike! 🎂🥳

@karapedsgastrodoc.bsky.social
@sarahanajjar.bsky.social
@chalysthalee.bsky.social
@linyhung.bsky.social
@taeseonwoo.bsky.social
@erfanehbarati.bsky.social

A hypothalamic circuit underlying the dynamic control of social homeostasis Nature - New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social...

Our latest findings on social behavior circuits is out: how does the brain responds to social isolation? Terrific work by @dingliu.bsky.social et al. uncovering a circuit with similar neural architecture as physiological needs (hunger, thirst, sleep..). Detailed thread soon.
rdcu.be/ebo63