Marc Veldhoen

Exclusive: retraction-prone editors identified at megajournal PLoS ONE Nature - Study says small editor group handled many problematic manuscripts — and a Nature investigation finds out who they are.

Exclusive: retraction-prone editors identified at megajournal PLoS ONE

Study says small editor group handled many problematic manuscripts — and a Nature investigation finds out who they are.

Bad science and practice undermines science as a whole.

www.nature.com/artic...

A Peripheral Neuron-to-Microglia Signaling Axis Connecting Transient Viral Infection to Persistent Neuroinflammatory States

Pre-print
Acute viral infections can cause lasting symptoms in anatomically distant, uninfected tissues. How?

www.researchsquare.c...
1/7

Check Goebbles images 1930s.......

It is a Western politician in a Westetn country using Western 1930s propaganda means and symbolism: you are very much supposed to look at it through a Western lens. That is his whole point for doing this.

No.

Not necessarily. It will have to be in the OE area, otherwise this probably does not count. It could be for some herpes viruses. But, if reawakening in the presence of immune memory is sufficient is another question. If there is reduced immunity possibly, otherwise possibly not.

Een post zo uit de jaren 1930. Maak de rechter wat meer karikatuur Joods en het is helemaal.

Nederland 2025, diepe schaamte voor dit soort politici en "partijen" die alleen boosheid, ongenoegen, xenofobia en haat verspreiden maar nooit iets positiefs zullen bijdragen.

Added info from @deepeez.bsky.social that herpesvirus do enter via the olfactory epithelium. Other viruses can do this via the apical heperan sulfate layer present, such as MuHV4 and MCMV (in mice). This may indicate something more general.

I didn't have the time to look this up.

Another one who does not understand the difference between proportions and numbers!

The OP implies that pDC are missing. Are they? Or other cells, especially from the myeloid lineage have proportionally increased, even pDC may be increased, but proportionally they are less


1/7

Fake footage of rabbits on trampolines misleads millions of viewers

Footage of rabbits on a trampoline has been viewed millions of times, but turns out to be fake. Numerous versions of these fake images are circulating on social media.

www.nu.nl/318817/vid...

results can be extrapolated to ME/CFS. Therapeutic oppertunities may eventually be derived from this, although how to enhance clean up will be difficult. Reducing (neuro)inflammation (e.g. steriods) may be the target.

A manuscript to keep an eye on!
7/7

This is a potentially exciting new insight. It would be good to understand if this mechanism is limited to viruses infecting the olfactory epithelium (respiratory viruses such as influenza and SC2) with involvemnt and the decline of olfactory sensory neurons critical, and if
6/7

Of interest is the involvement of complement activation, as previously reported by others.

The authors propose, in a manuscript stylistish made of for Nature, that transient infection can cause long-term symptoms via localized neuroinflammation.
5/7

Importantly, the authors saw viral clerance, which is in line with human data on SARS-CoV-2. Although viral debris ca be found, in both LC and non-LC, this does not seem to be the mechanism behind LC, with antivirals having limited success in reducing symptoms.
4/7

Using animal models and human clinical samples, they show that the virus selectively infects sustentacular cells in the olfactory epithelium, disrupting structure. Debris accumulates and triggers sustained activation of resident microglia cells.
3/7

A n example is longCOVID, in which neurological and other clinical symptoms can materialise after viral clearance.

The authors confirm that direct SARS-CoV-2 infection of the brain is often evaded, but sensory neurons can decline. This triggers a neuroinflammatory response.
2/7

A Peripheral Neuron-to-Microglia Signaling Axis Connecting Transient Viral Infection to Persistent Neuroinflammatory States

Pre-print
Acute viral infections can cause lasting symptoms in anatomically distant, uninfected tissues. How?

www.researchsquare.c...
1/7

Epigenetic memory of coronavirus infection in innate immune cells and their progenitors Severe COVID-19 can reprogram hematopoiesis and establish epigenetic memory in hematopoietic stem and progenitor cells (HSPC) and progeny myeloid cells for up to 1 year. These durable alterations, whi...

Epigenetic memory of coronavirus infection in innate immune cells and their progenitors

Immune cells respond to infection, and their gene regulation will be altered. That is how it works.

Het vaccin zorgt juist voor het voorkomen van infectie en het snel opruimen van geinfecteerde cellen, voordat het virus is een slaapstand kan gaan. Daarom is het belangrijk om te vaccineren voordat er mogelijk besmetting kan plaatsvinden. Helaas voor onze generatie te laat.

HPV is een herpes virus. Deze virussen hebben de mogelijkheid om latent aanwezig te blijven. Een soort slaapstand waarbij er geen activiteit is, en ons immuunsysteem het niet kan detecteren. Onder omstandigheden die niet geheel duidelijk zijn, zoals stress, kunnen ze weer aktief worden.

HPV Vaccination Learn about HPV vaccine basics, who should get it, when to get it, and why it's important.

2 vaccinaties zijn nodig zijn voor de leeftijd van 15 en sexuele activiteit, 3x daarna.
Wanneer mensen al sexueel actief zijn geweest en mogelijk besmet (besmettings graad is hoog) werkt het minder goed. Maar is er nog steeds (~45 jaar) een positief resultaat mogelijk.
www.cdc.gov/hpv/vaccines...

Fake footage of rabbits on trampolines misleads millions of viewers

Footage of rabbits on a trampoline has been viewed millions of times, but turns out to be fake. Numerous versions of these fake images are circulating on social media.

www.nu.nl/318817/vid...

It concerns this paper:
Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection
www.nature.com/artic...

Discusses many times, inlcuding here:
bsky.app/profile/mar...
7/7

No! It is proportional. Upion infection, the total number of white blood cells can increase dramatically. Myeloid cells such as monocytes and neutrophils can increase significantly. e.g. neutrophils increase from 50% to 75%. There less proportional space for T cells.
6/7

e.g. Upon infectiuon with bacteria Z, we see reduced CD4 T cell proportions, from 20% to 5%.

Should we panic, fear immunodeficiency, immune damage and start comparing bacteria Z with HIV?
5/7

Wrong. Upon inflammation many cell numbers will increase due to recruitment and proliferation. When looking at proportions within the CD4 T cell compartment, we see that all CD4 T cell numbers increase, and Treg cells increase in proportion the same: no specific induction.
4/7

Frequently you need both.

e.g. Upon infection with virus Y, there is an increase in the number of Treg cells.
Conclusion: Virus Y induces Treg cells.

Correct or wrong?
3/7

Be very carefull interpreting proportions and numbers. In some cases proportions are the ones to focus on. e.g. in differentiation assays, effector cells within a population, etc. Often numbers are required, e.g. claims about increases or decreases of a cell population.
2/7

Another one who does not understand the difference between proportions and numbers!

The OP implies that pDC are missing. Are they? Or other cells, especially from the myeloid lineage have proportionally increased, even pDC may be increased, but proportionally they are less


1/7

Beyond:"SARS-CoV-2 leaves lasting epigenetic marks that reprogram immune cells, causing chronic inflammation and dysfunctional responses"? Very wrong indeed, based on false interpretation.

That is days of work. I can pass you my hourly tariff.