Chloe Slaney

Honoured to receive the 25th Anniversary MRC Millenium Medal. My mid-1980s epidemiological apprenticeship was at the MRC Epidemiology Unit in Cardiff in the mid-1980s, and my senescence with the MRC IEU, closing in March 2028
🙏 MRC!
@ukri.org @uob-ieu.bsky.social
www.ukri.org/news/mrc-mil...

Massive congratulations, George!!

A special collection of 6 papers on cohort studies in China is just out in @bmj.com www.bmj.com/collections/...
with an editorial on the collection and the current publication climate www.bmj.com/collections/...

Associate Director, Equity Lab Salary: £120,800 Closing date: 9th November Contract type: Permanent Interview dates: 24th and 28th November The Wellcome Trust is a global charitable foundation. We improve health for everyone by fun...

Fantastic opportunity to lead the Equity Lab @wellcometrust.bsky.social working with the legendary Jimmy Volmink, details here wellcome.wd3.myworkdayjobs.com/en-GB/Wellco... Please repost so as many as possible can see this great opportunity

mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

Excited to share my poster at #ASHG2025 (Board 9173F)! Can’t wait to see everyone next week!

🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
www.biorxiv.org/content/10.1...

Apply to do a PhD with me, Laura Corbin, Gareth Hawkes and George Davey Smith ( @mendelrandom.bsky.social) in Bristol on identifying rare effects on health using new and innovative methods. Amazing team, great educational environment, lovely city. Forward to your undergrads wrapping up!

🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...

Highlights below!

Being Too Helpful At Work Can Hurt Your Career—Here’s How To Say No Women are more likely to take on behind-the-scenes duties at work—extra tasks like onboarding or event planning—and it's hurting their careers. Here's how to say no.

In a study of professors, women got 378 new work requests over 4 weeks vs 118 for men. Women spent more time on service, advising & teaching; men on research. Orgs should track who is taking extra duties & ensure they are rewarded and distributed fairly. www.forbes.com/sites/kimels...

Emma Robinson’s summary slide

Really enjoying Prof Emma Robinson’s accessibly-delivered talk on behavioural markers of mood/antidepressant effects! Really clear justification for focus on behavioural readouts of mood - and v thought provoking notes on welfare. #BAP2025

Studying the genetics of intelligence measures can help us understand the neurobiology of cognition and neurodevelopmental conditions 🧬🧠

We estimated missing intelligence test scores in @ukbiobank.bsky.social to reduce bias and boost power.

Preprint: www.medrxiv.org/content/10.1...

Thread 👇

Role of inflammation in depressive and anxiety disorders, affect, and cognition: genetic and non-genetic findings in the lifelines cohort study - Translational Psychiatry Translational Psychiatry - Role of inflammation in depressive and anxiety disorders, affect, and cognition: genetic and non-genetic findings in the lifelines cohort study

Netherlands study of 55,000 adults found higher inflammation (CRP) linked to more negative mood, anxiety, and slower thinking.

Genetic data also suggest CRP and GlycA may play a causal role in negative affect.

www.nature.com/articles/s41...

We provide context for this study, highlight what we think is its critical finding and key questions that still need to be addressed, before considering the potentially serious public health implications of this work.

Commentary by @mendelrandom.bsky.social and me on paper suggesting highly prevalent East Asian #ALDH2 null variant may magnify adverse effects of maternal alcohol use during pregnancy on child development.

▶️ onlinelibrary.wiley.com/doi/10.1111/...

@uob-ieu.bsky.social @bristoluni.bsky.social

Really enjoyed attending #ESHG - fantastic speakers presenting on a range of fascinating topics; hope to go again next year! 🧬

Check out our new OCD GWAS (53,660 cases and 2,044,417 controls) in @natgenet.nature.com 🧬🧠

Genetic risk was associated with excitatory neurons in the cortex and hippocampus. There was much genetic overlap with anxiety, depression, and anorexia.

Open access: www.nature.com/articles/s41...

This is huge! Honestly can't wait to dive into this dataset.

Last few days left to apply! Come and work with us!

Analyses using multiple imputation need to consider missing data in auxiliary variables Abstract. Auxiliary variables are used in multiple imputation (MI) to reduce bias and increase efficiency. These variables may often themselves be incomple

Final version published so time to talk about it: doi.org/10.1093/aje/...

When using multiple imputation to account for missing data we often use auxiliary variables (variables included in the imputation model but not the analysis model) to 1) reduce bias and 2) improve statistical efficiency.

Hello hello, I am trying to find even more postdoc positions to apply for in psychiatric genetics - please let me know if you are hiring or your lab is!

Eager to learn more about the latest immunopsychiatry research? 🔎

Be sure to come along to the @pixielabkcl.bsky.social Immunopsychiatry Meeting next week where I'll be presenting some of my PhD work! @uob-ieu.bsky.social

Link below 👇

Blood-based epigenome-wide association study and prediction of alcohol consumption - Clinical Epigenetics Alcohol consumption is an important risk factor for multiple diseases. It is typically assessed via self-report, which is open to measurement error through recall bias. Instead, molecular data such as...

You might forget how much you drink… but your body remembers.

Prediction of alcohol consumption using blood-based DNA methylation (correlates better with brain health self report!)

clinicalepigeneticsjournal.biomedcentral.com/articles/10....

Scientific discovery and advance is not, and never has been, “efficient”.

🚨PLEASE SHARE: Senior reseach post: come and work at the IEU with Gib Hemani and @mendelrandom.bsky.social on Mendelian randomization, become my co-worker :) – research posts with closing date 5th February 2025.

Lovely evening celebrating the end of 2024 in the Immunopsychiatry Group!