RyanLab_MBU

Preprint: PIEZO1 mechanosensing at the plasma membrane as a key regulatory event in nucleic acid-induced immunity, with different functional outcomes based on the cargo structure
www.biorxiv.org/content/10.1...

a cartoon character standing in front of the word science ALT: a cartoon character standing in front of the word science

Good Sunday, all. This week was a blast for @cancermetabolism and @mitochondrialbiology. Don't miss the curated issue of papers, check it here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"There was another life that I might have had, but I am having this one."-Kazuo Ishiguro

Distinct proteomic and acylproteomic adaptations to succinate dehydrogenase loss in two cell contexts https://www.biorxiv.org/content/10.1101/2025.08.01.668168v1

Regulation of airway fumarate by host and pathogen promotes Staphylococcus aureus pneumonia - Nature Communications This study reveals how the pathogen Staphylococcus aureus adapts to the lung microenvironment, rich in host metabolites fumarate and itaconate, by using a key enzyme, FumC, to support its metabolic fi...

Pleased to share our latest study @natcomms.nature.com! We show that the host metabolites fumarate and itaconate impose selective pressure on Staphylococcus aureus, driving its adaptation via the enzyme FumC. Grateful to all who contributed to this work!
www.nature.com/articles/s41...

This surprisingly relaxing footage is from SIX MILES under the ocean – and it’s the deepest ecosystem yet discovered

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry - Nature APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.

www.nature.com/articles/s41...

Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

Respiratory infections reactivate dormant metastatic breast cancer cells in mouse lungs, correlating with evidence in humans that #SARS-CoV-2 infection increases the risk of cancer-related mortality & lung metastasis

😎 biology but double whammy for cancer patients

www.nature.com/articles/s41...
🧪

ACLY inhibition promotes tumour immunity and suppresses liver cancer - Nature Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of ...

www.nature.com/articles/s41...

Manipulation of the nucleotide pool in human, bacterial and plant immunity - Nature Reviews Immunology Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved from bacteria to humans manipulate the nuc...

We wrote a review on the free nucleotide pool as a central playground in human, bacterial, and plant immunity – now out in Nature Reviews in Immunology

www.nature.com/articles/s41...

Was fun to write this piece with Dina Hochhauser!

Here is a thread to explain the premises

1/

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...

Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...

Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...

Congratulations Triona, Andy and co!

Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure - Nature Communications Here they show that HDAC6 inhibition regulates fumarate hydratase (FH), disrupts mitochondria, increases fumarate, and causes cancer cell death. This suggests that HDAC6 inhibition could be a strategy...

Huge congratulations to Andy on the publication of his PhD work! This was a massive team effort, thanks to the lab for helping out & collaborators: Ingmar Schoen, Emmar Kerr @mariemcilroy.bsky.social
Link here:
www.nature.com/articles/s41.... Thanks to funding from @researchireland.ie

🔊Last weeks #immunometabolism findings
@biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

A large & varied collection this week (1/n)

The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
sciencedirect.com/science/arti...

Xylulose 5-phosphate fosters sustained antitumor activity of progenitor-like exhausted SLC35E2+ CD8+ T effector cells Shi et al. demonstrate that CD8+ T cell-mediated elimination of high-XYLB tumor cells releases relatively high Xu5P, establishing a feedforward loop to sustain Xu5P-responsive SLC35E2+ CD8+ progenitor...

cell.com/cell-metabol... (10/n)

JAK/STAT inhibition protects glucocorticoid receptor knockout mice from lethal malaria-induced hypoglycemia and hyperinflammation | EMBO Molecular Medicine imageimageIn malaria, loss of disease tolerance results in severe complications that are challenging to manage and can result in death. This study shows that disease tolerance in malaria is mediated b...

embopress.org/doi/full/10.... (9/n)

Inhibition of pyrimidine de novo synthesis fosters Treg cells and reduces diabetes development in models of Type 1 Diabetes In autoimmune Type 1 Diabetes (T1D), aberrant immune activation promotes regulatory T cell (Treg) impairments thereby boosting progression of islet au…

sciencedirect.com/science/arti... (8/n)

LARP4-mediated hypertranslation drives T cell dysfunction in tumors - Nature Immunology The authors show that LARP4 drives T cell dysfunction in tumors by promoting hypertranslation of oxidative phosphorylation-related mRNAs, resulting in mitochondrial dysfunction. They also target LARP4...

nature.com/articles/s41... (7/n)

Unraveling mitochondrial pyruvate dysfunction to mitigate hyperlactatemia and lethality in sepsis Nuyttens et al. demonstrate that sepsis-associated hyperlactatemia results from impaired mitochondrial pyruvate metabolism. While MPC and PCX remain functional, thiamine deficiency suppresses PDC acti...

cell.com/cell-reports... (6/n)

Macrophage fatty acid metabolism under chronic hypoxia shapes γδ T cell recruitment via CCL22 Human metabolism; Immune response; Cancer

cell.com/iscience/ful... (5/n)

Mitochondrial bioenergetic failure in SLE immunocytes: Targeting fitness for therapy Systemic Lupus Erythematosus (SLE) is characterized by dysregulated immune responses linked to immunometabolic perturbations. While mitochondrial dysf…

sciencedirect.com/science/arti... (4/n)

Early methionine availability attenuates T cell exhaustion - Nature Immunology The tumor environment is nutrient deficient. Here the authors show that early availability of methionine is critical for optimal T cell activation and prevents T cell dysfunction, and that dietary met...

nature.com/articles/s41... (3/n)

insight.jci.org/articles/vie... (2/n)

🔊Last weeks #immunometabolism findings
@biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

A large & varied collection this week (1/n)

The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
sciencedirect.com/science/arti...

an illustration of a bird holding a stack of books with reading time written above it ALT: an illustration of a bird holding a stack of books with reading time written above it

Good Sunday all. A beautiful selection of papers in #cancermetabolism and #mitochondrialbiology is ready for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"If your eyes are blinded with your worries, you cannot see the beauty of the sunset." - Jiddu Krishnamurti

Visual representation of "mitochondrial DNA (mtDNA)"

𝐌𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚𝐥 𝐃𝐍𝐀 (𝐦𝐭𝐃𝐍𝐀) is a circular DNA in the mitochondrion that encodes 22 transfer RNAs, 2 ribosomal RNAs, and 13 protein subunits, all of which are involved in the oxidative phosphorylation pathway. Full definition: nej.md/3GQZ0wK

#ScienceSky

Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Wow

Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions

ki.se/en/about-ki/...

Expression level of anti-phage defence systems controls a trade-off between protection range and autoimmunity - Nature Microbiology The authors examine several defense systems and find that increased expression enhances their protection range, albeit at a cost of autoimmunity.

Expression level of anti-phage defence systems controls a trade-off between protection range and autoimmunity
By Nitzan Aframian and Avigdor Eldar.
www.nature.com/articles/s41...

Wow. Scientists have edited mosquito DNA to prevent the spread of malaria to humans "while supporting essential physiological functions... and negligible fitness costs" to the mosquito population.

Potentially ending the mosquito-born spread of malaria to humans.

www.nature.com/articles/s41...

Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining IFNγ @sciimmunology.bsky.social #Mathis
www.science.org/doi/10.1126/...

Despite importance to metabolic disease, US govt no longer values contributions of immigrant scientists, @harvardmed.bsky.social #NIA #NIDDK