RyanLab_TCD

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart @cp-immunity.bsky.social
www.cell.com/immunity/ful... @jeffdowney11.bsky.social @filswirski.bsky.social

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy - Nature Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuro...

#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy!
doi.org/10.1038/s415...

Single Cell Glucose Uptake Assays: A Cautionary Tale Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...

****2-NBDG does not measure glucose uptake****

Just your regular reminder of this fact 😁.

See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.

This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄

pmc.ncbi.nlm.nih.gov/articles/PMC...

A DNA-based nanodevice senses purinergic signaling and drives an immune switch for resolving inflammation
www.nature.com/articles/s41...
@natcomms.nature.com

YL1004 is a SARS-CoV-2 papain-like protease inhibitor with immunomodulatory and antiviral activity in mice
www.nature.com/articles/s41...
@natcomms.nature.com

Would be great!

Immunometabolism researchers are meeting in Newcastle on 16-17 April!

Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26

Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45

Looking forward to speaking at this #UKimmunomet26 conference in Newcastle. Make sure to check it out! @britsocimm.bsky.social

www.immunology.org/events/fuell...

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Spatiotemporal regulation of energetic charge dictates T cell function @natcomms.nature.com

Why does mitochondrial disease still take ~8 years to diagnose?
This study shows most delay happens before suspicion, despite early seizures, hypotonia & stroke being documented years earlier.
Recognition — not testing — is the bottleneck.
doi.org/10.1002/jmd2...

Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...

#WeekendRead! #LocationLocationLocation! Sng, Andoniou,
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...

But also agree, Lovely work 👏

Think you tagged the wrong lab Lister, apologies @tjryan.bsky.social 😆

The transition from monocyte to tissue-resident macrophage requires DHPS - Nature In mice, DHPS supports the maturation, maintenance and function of tissue-resident macrophages via the polyamine–hypusine axis, with implications for macrophage-targeting therapies.

The transition from monocyte to tissue-resident macrophage requires DHPS 🧪 #immunometabolism

www.nature.com/articles/s41...
www.nature.com/articles/s41...

Microglial activity during postnatal development is required for infantile amnesia in mice Infantile amnesia limits recall of early-life memories, but its cellular basis is unclear. This study reveals that transient microglial activity during postnatal development regulates infant memory pe...

💡 #ListerFellow @tjryan.bsky.social et al. reveal how microglia immune cells help organise memory engrams during early development. A clue to the mechanisms regulating "infantile amnesia" and why we forget our baby days? @ryanlab.bsky.social

👉 PLOS Biology journals.plos.org/plosbiology/...

Hi Erik, I'm an assistant professor in Trinity College Dublin, I frequently share the latest research in immunometabolism, immunology, and mitochondrial biology, and would love to be added to this feed. My google scholar link - scholar.google.com/citations?us...

Structural basis for late maturation steps of mitochondrial respiratory chain complex IV within the human respirasome #mitochondria
rdcu.be/eZXXC

Preprint: Type I IFN activates border-associated macrophages to drive MHC-I–dependent immune surveillance after stroke
www.researchsquare.com/article/rs-8...

Disease tolerance and infection pathogenesis age-related tradeoffs in mice - Nature Disease course and pathology an infection may cause can change owing to the structural and functional physiological changes that accumulate with age, but therapy can be tailored accordingly; disease t...

#NoTimeToDie! Ayres &co show @nature.com that young & aged mice initiate different disease tolerance mechanisms to survive #sepsis. Dying young mice have cardiomegaly while aged mice cardiac atrophy. Opposite in surviving mice, with Foxo1 🦊 being protective in young & detrimental in aged mice!

⚠️ We are hiring a Postdoctoral Research Associate ⚠️
🚨 Deadline 9th February 2026 🚨
👍 Please like and share with your network! 👍

#CambridgeUniversity #PostdoctoralResearch #JobOpportunity

For enquiries please contact me at LP429@CAM.AC.UK or use this 🔗 to apply: www.cam.ac.uk/jobs/postdoc...

Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production - Nature Metabolism Hexokinase detachment from the outer mitochondrial membrane is shown to support aerobic glycolysis in cancer cells. Differential localization of the HK1 isoform to the outer mitochondrial membrane, co...

Latest collection of papers on mitochondria in health and disease! #MitochondrialDisease #week3

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

www.nature.com/articles/s42...

📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting paper:

Metabolic adaptations rewire CD4+ T cells in a subset-specific manner in human critical illness with and without sepsis

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity @cellcellpress.bsky.social @thexavierlab.bsky.social @broadinstitute.org
www.cell.com/cell/fulltex...

Obesity rewires nucleotide metabolism in immune cells, making inflammatory responses via NLRP3 inflammasome much easier to trigger
www.science.org/doi/10.1126/... @science.org @zhenyuzhong.bsky.social @utswim.bsky.social

Polyamine-dependent metabolic shielding regulates alternative splicing - Nature Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

Polyamine-dependent metabolic shielding regulates alternative splicing

www.nature.com/articles/s41...

3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis
cell.com/cell/fulltex...
cell.com/cell/fulltex...
www.cell.com/cell/fulltex...

📢Last weeks #immunometabolism discoveries
@biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Albumin orchestrates a natural host defence mechanism against mucormycosis

Good Sunday, all. Here is a great summary of last week's papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... Biomed News #keepreading

"Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman

TLR4al senses heme as a key damage/danger-associated molecular pattern to activate immune responses in lower vertebrates Abstract. Toll-like receptor 4 (TLR4), a critical pattern recognition receptor, detects microbe- and damage/danger-associated molecular patterns to trigger

#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...

Local mitochondrial physiology defined by mtDNA quality guides purifying selection Author summary Mitochondria are essential organelles in our cells that convert nutrients into usable cellular energy. They contain their own DNA, and mutations in this DNA can compromise mitochondrial...

How do cells assess mtDNA quality?

Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection.

We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae.

Great collaboration with the Schmoller Lab.

journals.plos.org/plosgenetics...
🧬⚡