RyanLab_TCD

Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation A model for hit-and-run viral carcinogenesis in the bladder.

What causes bladder cancer initiating mutations?
Our paper in Science Advances asks the question: can BK virus infections of normal urothelium lead to the APOBEC3 mutational signatures found in bladder cancers?
We found that they can!

Preprint: Systematic discovery of TIR-based immune signaling systems in bacteria

Conservation of TIR-derived signals accross the tree of life! We found bacterial TIR immune systems that signal via canonical cADPR (like in humans) and 2'cADPR (a plant immune signal).

Documented 11 Thoeris types

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

A huge collection inside!

Interesting finding:

Itaconate transport across the plasma membrane and Salmonella-containing vacuole via MCT1/4 modulates macrophage antibacterial activity

Mitochondrial glutathione transporter SLC25A40 regulates macrophage cytokine production - Scientific Reports Scientific Reports - Mitochondrial glutathione transporter SLC25A40 regulates macrophage cytokine production

www.nature.com/articles/s41...

ERC success rates are tanking and the move is... even bigger grants for fewer people? smh

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by the synergy of innate immune activation and metabolic stress. This process is regulated by mTORC2 and involves persis...

#NoTimeToDie! Welcome mitoxyperiosis! ⁦‪Kanneganti, Wang‬⁩ &co show ⁦‪@cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!

SLC7A8 is essential for metabolic fitness and function of Th2 cells, say Santosh Panda, Marco Colonna and colleagues @washumedicine.bsky.social: rupress.org/jem/article/...

#InfectiousDisease #HostDefense #Inflammation #MucosalImmunology #Helminths #Allergies

🤣🤣 very funny @crismunozp.bsky.social and you're right of course 🤣🤣

Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death Nature - Enrichment for efferocytic macrophages in the islets of Langerhans promotes the accumulation of anergic-like CD4+ T cells and dampens autoimmune diabetes.

Super cool @nature.com paper from Kodi Ravichandran @washumedicine.bsky.social: Limited β-cell death reprograms islet macrophages into a tolerogenic state ("e-Mac"), expanding anergic-like CD4+ T cells and suppressing autoimmunity in NOD mice. Mechanism via IGF-1.
www.nature.com/artic... 🧪

Good Sunday, all. What a great week for #cancermetabolism and #mitochondrialbiology. Find here a selection of groundbreaking discoveries: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"Trying to define yourself is like trying to bite your own teeth."-Alan Watts

Thank you for sharing Catalina! 😄

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

Rich collections of papers on #mitochondrialdisease from the last 2 weeks! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social

Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...

📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️

biomed.news/bims-imicid/...
biomed.news/bims-imicid/...

Exciting to have a paper in the collection!

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice

Thank you Ivan 🙏

Thank you Christian!

Thank you Antonio 🙏

Thank you Christian 🙏

Thanks for sharing @labwaggoner.bsky.social !!

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...

Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism

This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.

Please check it out!

www.nature.com/articles/s41...

Measuring mitochondrial membrane potential | The EMBO Journal EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Measuring mitochondrial membrane potential | The EMBO Journal www.embopress.org/doi/full/10....

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉

Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!

#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social

🔗 www.nature.com/articles/s42...
🧵1/17

Termination of the integrated stress response Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...

Termination of the integrated stress response | Science www.science.org/doi/10.1126/...

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy - Nature Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistan...

www.nature.com/articles/s41...
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/... @stanfordmedicine.bsky.social @shady-myounis.bsky.social

Tumour sampling conditions perturb the metabolic landscape of clear cell renal cell carcinoma - Nature Communications Yong et al. highlight how sampling conditions affect metabolic profile in renal cancer, showing that prolonged ischemic exposure disrupts tissue metabolome stability and masks important phenotypes, su...

I am very happy to share this paper from a great scientist and surgeon, Cissy Yong, on how warm ischaemia can affect the metabolic profile of a tumour: www.nature.com/articles/s41... 💥 👏
full text access here rdcu.be/ePcEK

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...

A new collection of papers on #mitochondrialdisease from #week45! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...

Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation Hexokinase 2 (HK2) is traditionally known for its metabolic role in glycolysis. This study shows that it also functions as an RNA-binding protein that regulates mRNA translation, particularly of SOX10...

Hexokinase 2, the latest glycolytic enzyme that also controls mRNA translation!

Nonmetabolic function of HK2 acting as an RBP and translation regulator.

dx.plos.org/10.1371/jour...

Last week's #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Interesting finding:

Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses

Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis #mitochondria

www.cell.com/molecular-ce...

Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.

Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social