Ildem Akerman Lab

Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication Tong et al. utilize advanced imaging approaches to reveal that beta cells located next to alpha cells are specially adapted as glucagon sensors by virtue of their high expression levels of GLP1R. Thes...

A regulated pathway through which glucagon modulates insulin release via alpha to beta cell communication and control of GLP-1R internalization and beta cell Ca2+ responses to high glucose @cp-cellmetabolism.bsky.social @daveyboyhod.bsky.social #islets www.cell.com/cell-metabol...

We are launching a new initiative to support experimental design, data management/analysis and bioinformatics. Early days yet, but check it out here.

www.bcell.org/adi-datasci....

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

Stem cell islets for those living with T1D! www.nejm.org/doi/full/10....

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

A huge step forward for cell replacement therapy for #T1D @NEJM

Vertex clinical trials for zimislecel

www.nejm.org/doi/full/10....

Photograph of Lori Sussel.

🧫 We have a packed programme for the second day of the European Islet Study Group conference in Malmö. One of the highlights of today is the keynote lecture by Lori Sussel from University of Colorado. She presents research about the regulation of islet cell fates.
#eisg2025 #diabetes

Congratulations!!!

Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer - Nature Spatially resolved transcriptomic profiling of primary tumours and metastases from patients with pancreatic cancer provides insight into the evolutionary progression to metastasis, and the variation in clonal architecture within and between individuals.

www.nature.com/articles/s41...

Chain Florey Post CCT Transition to Independence Fellowship - MRC Laboratory of Medical Sciences The Chain Florey Transition-to-Independence (TTI) Fellowship scheme provides a unique opportunity to clinician scientists who have recently completed their clinical training (or will do so in the next...

Calling clinician scientists with focus on mechanistic discovery science and experimental medicine who recently have completed or are about to complete their clinical training - great opportunity! Please re-skeet and apply to @mrc-lms.bsky.social by 4th March 2025 lms.mrc.ac.uk/work/vacanci...

EUWIN - European Women in Endocrinology - join us in Copenhagen this May!

🚨🚨 New pre-print from the lab. led by the amazing @alejotorrescano.bsky.social !

Alejo & Co. elegantly decode the spatial logic of progenitor cell organization in the developing pancreas — from individual cells to structured cellular communities 🔬🔬🧫🧪
Check-it out ⤵️

1 day left to apply!

Professors (2 positions) - Canada Excellence Research Chairs - Health - Sherbrooke (City), Quebec (CA) job with Universite de Sherbrooke | 12837575 Université de Sherbrooke is inviting applications for two professor positions, with the selected candidates expected to hold a prestigious chair

Canadian Diabetes Job! www.nature.com/naturecareer...

This issue of The Endocrinologist is dedicated to diabetes research (our SC-islets on the cover!)

www.endocrinology.org/endocrinolog...

📢 Remember that the Abstract Submission Deadline for #EISG2025 is on April 1st! 📢

Don't miss your chance to share your research at the European Islet Study Group 2025 in Malmö, June 11-13! 🏙️🇸🇪

🔗 Submit your abstract by April 1st: eisg2025.se

#DiabetesResearch #CallForAbstracts

PhD Opportunity in Bioinformatics – Fully Funded for UK Home Fee Students at University of Birmingham on FindAPhD.com PhD Project - PhD Opportunity in Bioinformatics – Fully Funded for UK Home Fee Students at University of Birmingham, listed on FindAPhD.com

We are looking for a keen bioinformatician for a fully funded PhD position!
Drop me an email with your CV!

www.findaphd.com/phds/project...

🚨 3 DAYS LEFT! 🚨

The countdown is on — early bird registration for #EISG2025 closes March 13! ⏳🏃‍♂️

Secure your spot and submit your abstract to join the European Islet Study Group 2025 in Malmö, June 11-13. 🏙️✨

🔗 Register now: eisg2025.se

#DiabetesResearch

Our job posting for 1 or more PDF positions in Vancouver Canada is now live here: tinyurl.com/4mrjw3m2

Please share/repost and apply soon!

We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction.

https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1

I have funding through at least 2031 for postdoctoral researchers with expertise in islet biology or cell-based therapies for, or modelling of, diabetes. Bring your expertise to a country that values it. 🇨🇦

Contact info on my website.

Head, Division of Endocrinology - BC Children’s Hospital & University of British Columbia at PHSA Learn more about applying for Head, Division of Endocrinology - BC Children’s Hospital & University of British Columbia at PHSA

We are recruiting for the Head of the Division of Endocrinology at BC Children’s Hospital, @bcchresearch.bsky.social and @ubcmedicine.bsky.social. Please apply! https://jobs.phsa.ca/job/vancouver/head-division-of-endocrinology-bc-children-s-hospital-and-university-of-british-columbia/909/76783745776

⏳ There is one week left to submit your 3Rs Challenge idea for the 2025 CRACK IT open call. Download the form today and submit to crackitenquiries@nc3rs.org.uk by Monday 10 February: nc3rs.org.uk/crackit/spon...

Still time to apply!

Applications from US welcome – four years can feel longer or shorter depending on where you are 😉

I have a wonderful scientist in my lab who is looking to move to Europe. Is anyone looking for a staff scientist? She has a PhD. She is particularly in her element doing field work. Great skills with rodents and very open to non-rodent positions as well.

Please send leads, please amplify!

A scalable system using mini-organs to test personalized RNA therapy Platform to accelerate the testing of antisense oligonucleotides.

A rapid and efficient method developed to create stem-cell-based 3D mini-organs derived from the cells of patients offers a way to evaluate personalized treatments using RNA therapies for rare genetic diseases

https://go.nature.com/3POiHpJ

We have room and $ for postdoctoral fellows to join our team in beautiful Vancouver 🇨🇦. Get in touch if interested.

Is there a version where the comet hits the earth, goes back to its orbit for 4 years and comes back to hit it again?

If you’re interested in doing Postdoc work in Vancouver this is a great opportunity, check out our website and get in touch soon (www.betacell.ca)!

📣 Hiring, please forward widely!!

Two postdoc openings to work on genomics of diabetes

1. Computational regulatory genomics/statistical genetics.
2. Experimental cell-based modeling

DM if interested

@crg.eu

shorturl.at/O3wMi

shorturl.at/ieyZy

Last day to apply!!

Excited to have been involved in this: The utility of at home continuous glucose monitoring coupled with machine learning to predict metabolic subtypes. Study was led by Mike Synder & Tracey McLaughlin & championed by Ahmed Metwally. @natureportfolio.bsky.social www.nature.com/articles/s41...