Daniel Drucker

Call your parents and your children every day. Cherish your friends and family. Respect your colleagues. Be kind to your neighbours. Don’t go to bed angry. Be the positive person in the room. Life is precious, enjoy every moment. Be kind, it costs nothing and makes a difference

Disease accumulation and distribution across the lifespan in Swedish centenarians and non-centenarians: a nationwide life course comparison of longevity and health resilience Our findings of a lower overall disease burden, a delayed onset of multiple conditions, and fewer co-occurring diseases over time among centenarians (compared to non-centenarians) suggest a preserved ...

New research from Sweden has determined that people who live longer are healthier and have fewer major health issues www.thelancet.com/journals/ecl...

Trainees. Trust yet verify. Reagent validation is annoying, tedious, time consuming, expensive, yet essential. Authorship on a flawed paper is not what anyone aspires to. Don’t let flawed reagents mess up your science. Be the wheat, not the chaff #Reproducibility

It’s should be noted that insulin is still present in these experimental models, although at low levels. In work out of the Kieffer lab leptin was not able to rescue complete insulin deficient mice.

The authors detect GLP-1R using an antibody from Uping Bio, that also detects GLP-1R in HepG2 cells and HeLa cells, cell lines that do not express the GLP-1R. More than 3 decades after cloning of the GLP-1R, many of the papers reporting GLP-1R expression remain compromised by non-validated reagents

Semaglutide Mitigates Ischemic Brain Injury by Inhibiting Ferroptosis via Modulation of FoXO1 and DRP1 Pathways - Molecular Neurobiology Multiple pathogenic processes contribute to cerebral ischemia–reperfusion injury (CIRI); however, their relative importance and sequence remain unclear, warranting further investigation. Although our ...

In this interesting paper the authors study the importance of the GLP-1R pathway and semaglutide in mitigating experimental brain injury in rats link.springer.com/article/10.1...

12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII - Nature Communications Cardiovascular function declines with age. In this study, the authors show that the BAT-derived lipokine 12,13-diHOME preserves cardiac function in aged mice by attenuating pathological CaMKII activit...

The BATokine 12,13-diHOME revealed as a promising candidate for combating age-related cardiovascular dysfunction www.nature.com/articles/s41...

Translational studies are warranted to determine whether the most severe manifestations of uncontrolled T1D in humans can be ameliorated through increased leptin signaling in the brain. www.jci.org/articles/vie...

The Potential of Using Glucagon-Like Peptide-1 Receptor... : Cardiology in Review o mitigate or even prevent the effects of sepsis. Preclinical studies demonstrate that GLP-1 agonists reduce excessive inflammation, oxidative stress, and mitochondrial dysfunction while preserving en...

A bridge too far or logical hypothesis-should we test GLP-1 medicines in sepsis? journals.lww.com/cardiologyin...

More than a leaky gut: how gut priming shapes arthritis - Nature Reviews Rheumatology This Review discusses how alterations in the gut are linked to the development of arthritis. The authors challenge the concept of the ‘leaky gut’ hypothesis, stating that the effects of intestinal per...

The complex roles of the gut and pathophysiology of #Arthritis #Inflammation #Microbiota www.nature.com/articles/s41...

Association of GLP1‐receptor agonist use with liver disease progression, major cardiovascular events, and mortality in people with hepatic steatosis and diabetes Aims Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease in the United States. MASLD can progress to liver cirrhosis and is associated ...

Real world data from the VA. DPP-4i vs. GLP-1 medicines and outcomes dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...

SURPASS CVOT #T2D #Tirzepatide Non inferior but numerically superior for some endpoints #CVD investor.lilly.com/news-release...

Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism - Nature Microbiology Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents.

Here the authors propose that gut #microbiota derived peptides exhibit potential for prevention and treatment of human metabolic disorders www.nature.com/articles/s41...

Combining a diet rich in fermentable carbohydrates with metformin improves glycaemic control and reshapes the gut microbiota in people with prediabetes - Nature Metabolism In this double-blind, randomised, crossover trial, a diet rich in fermentable foods was shown to improve the glucose-lowering efficacy of metformin due, at least in part, to changes in gut microbiota ...

Based on varying exposure to FODMAP #diet content over 10 days in 26 PPL with metformin for 5 days the findings have implications for personalizing nutritional and pharmacological interventions to prevent #diabetes www.nature.com/articles/s42...

Multimodal AI correlates of glucose spikes in people with normal glucose regulation, pre-diabetes and type 2 diabetes - Nature Medicine Multimodal data from 347 deeply phenotyped individuals including healthy, prediabetic individuals and individuals with T2D report remotely acquired patterns of glucose control via continuous glucose m...

Will more detailed data on glycemic excursions and metabolic phenotyping change the clinical approach to prevention, diagnosis or treatment of #T2D www.nature.com/articles/s41... #AI

Comparative single-cell lineage tracing identifies distinct adipocyte precursor dynamics in skin and inguinal fat Morris and colleagues use single-cell lineage tracing to track adipocyte formation in mouse skin. They demonstrate that distinct precursor populations—progenitors and immature preadipocytes—exhibit di...

The cellular hierarchy and molecular mechanisms underpinning rapid adipogenesis in skin adipose tissue
www.cell.com/cell-stem-ce...?

Phimosis is defined as the inability to retract the skin (foreskin or prepuce) covering the head (glans) of the penis. A database study from Denmark reveals increased risk with use of SGLT2i #T2D diabetesjournals.org/care/article...

The Heterogeneity of Type 1 Diabetes: Implications for Pathogenesis, Prevention, and Treatment—2024 Diabetes, Diabetes Care, and Diabetologia Expert Forum This article summarizes the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organized by the edit

Heterogeneity of type 1 #diabetes where do do we stand and where we go from here? diabetesjournals.org/diabetes/art... See the 95 minute symposium here

Low-dose metformin requires brain Rap1 for its antidiabetic action Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.

And you thought #metformin lowered glucose via the liver? Here loss-of-function and gain-of-function studies suggest that VMH Rap1 is indispensable for the antidiabetic effects of metformin in mice #diabetes www.science.org/doi/10.1126/...

ACLY inhibition promotes tumour immunity and suppresses liver cancer - Nature Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of ...

Targeting tumour metabolism through ATP citrate lyase can rewire immune function and suppress #cancer progression in #MASH #HCC www.nature.com/articles/s41...

Kevin Hall, uncensored: Top nutrition scientist on clashing with MAHA and what he actually eats 'They’re not interested in the science': Former NIH nutrition scientist Kevin Hall on how his work with MAHA fell apart.

Some wide ranging candid thoughts from Kevin Hall @kevinh-phd.bsky.social #Nutrition www.statnews.com/2025/07/30/k...

Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice D-lactate from the gut microbiota influences blood glucose and fatty liver disease. Trapping D-lactate in the gut improves blood glucose and lowers liver inflammation and fibrosis during obesity.

Here Professor Schertzer and colleagues identify that microbial-derived D-lactate contributes to host glucose and lipid metabolism and can be trapped therapeutically to improve metabolic disease during #obesity www.cell.com/cell-metabol...

Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy Objective Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has neuroprotective effects in preclinical models of multiple system atrophy (MSA). We investigated these effects in a proof-.....

Exenatide qw over 48 weeks and Multi-system Atrophy onlinelibrary.wiley.com/doi/10.1002/...

A new comprehensive review of the proglucagon-derived peptides #disbetes #obesity #shortbowelsyndrome journals.physiology.org/doi/abs/10.1...

Predictors of response and enteral autonomy in children with short bowel syndrome treated with teduglutide: a real-life multicentre cohort study In children with SBS, longer residual small bowel, better nutritional status and absence of liver disease were associated with response to teduglutide. Complete PN weaning was predicted by lower calor...

In 104 teduglutide-treated children with #shortbowelsyndrome a clinical response was detected in 70% and.complete weaning from parenteral nutrition was achieved in 22% www.thelancet.com/journals/ecl...

Lipidema and exenatide- 5 cases www.mdpi.com/2039-7283/15...

Impact of GLP-1 receptor agonists for type 2 diabetes... : RETINA n-GLP-1RA therapy. AMD incidence was determined over the first 1 to 10 years of treatment. Patients with baseline early or intermediate nonexudative AMD were also matched and assessed for progression ...

A retrospective cohort study suggests that GLP-1RA use may reduce the both the risk and progression of AMD and progression of early and intermediate AMD to advanced AMD in adults with #T2D journals.lww.com/retinajourna...

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying circulating senoproteins co...

The proteomic blueprint of #aging across 13 human tissues www.cell.com/cell/abstrac...

Fasting, metabolism #longevity and health. Benefits, risks and unknowns academic.oup.com/edrv/advance...

PVH and SON Oxytocin neurons differentially modulate food intake by either reducing or increasing caloric consumption, respectively.
www.sciencedirect.com/science/arti...