Daniel Drucker

Oral semaglutide disappoints in the two evoke trials, failing to reduce the rate of cognitive decline #Alzheimers disease #Dementia www.novonordisk.com/content/nnco...

Bridging the variant-to-function gap in type 2 diabetes: advances and challenges - Diabetologia Type 2 diabetes is a polygenic, heterogeneous disease affecting over 530 million individuals worldwide, a number projected to rise to 1.3 billion by 2050. Genome-wide association studies have identifi...

On the cusp of closing the genetic association and mechanism gap while laying the foundation for future precision medicine approaches in type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...

Efficacy and safety of efsubaglutide alfa in individuals with type 2 diabetes (SUPER1): a randomised, double-blind, placebo-controlled, Phase IIb/III trial - Diabetologia Aims/hypothesis Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have become an important option in clinical use for type 2 diabetes due to their dual benefits of glycaemic management and metaboli...

P3 data for Efsubaglutide the once weekly immunoglobulin-based GLP-1 medicine approved in China for #T2D @diabetologiajnl.bsky.social link.springer.com/article/10.1...

A reminder of the primary endpoint in the evoke trials, the change in the CDR – Sum of Boxes (CDR-SB) score from baseline to week 104 #Alzheimers www.understandingalzheimersdisease.com/-/media/File...

As disclosure of evoke and evoke+ trial results for oral semaglutide in people with imaging or biomarker+ #Alzheimers disease approaches, a reminder of the primary and secondary endpoints alzres.biomedcentral.com/articles/10....

Human #genetic evidence in humans is consistent with direct TAS2R38 actions in postprandial glycemia, supporting TAS2R38 as a novel therapeutic target for glucose regulation.
diabetesjournals.org/diabetes/art...

Towards reducing the already low risk of peri-procedural GLP-1 medicines linked aspiration. Fasting duration, rather than time since last GLP-1 dose, is a key determinant of retained gastric solid content link.springer.com/article/10.1...

Body-wide multi-omic counteraction of aging with GLP-1R agonism GLP-1R agonism counteracts body-wide aging in a brain-dependent manner, mimicking the molecular effects of mTOR inhibition.

Studies in aging male mice with extensive multi-OMICs analyses show that glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment broadly counteracts age-related changes n part via the hypothalamic GLP-1R #aging www.cell.com/cell-metabol...

Elucidating pathway-selective biased CCKBR agonism for Alzheimer’s disease treatment Clinical evidence from AD patients reveals an association between impaired CCKBR-Gq signaling and disease severity, guiding structure-based design of a Gq-biased agonist that rescues memory and pathol...

Preclinical studies reveal that CCKBR-Gs and -Gq signaling, rather than CCKBR-Gi signaling, are beneficial for #Alzheimers disease (AD) treatment. www.cell.com/cell/abstrac...

A small P2 trial of 24 patients with #T1D randomized to placebo vs. Tirzepatide. Meaningful #weightloss without SAEs
diabetesjournals.org/care/article... ada.silverchair-cdn.com/ada/content_...

A spotlight on key concepts defining postprandial glucagon metabolism in people with and without type 1 #diabetes diabetesjournals.org/diabetes/art...

Additive Effects of GLY-200 (Oral Pharmacologic Duodenal Exclusion Therapy) and GLP-1R Agonist in Obesity Management Type 2 diabetes and obesity impact billions of people and the global prevalence is only growing. Current treatment options, which include pharmacother…

Preclinical data suggest that GLY-200, an orally administered polymer that targets mucus and enhances barrier function, in combination with GLP-1RAs, holds promise as a
novel therapeutic strategy for #obesity www.sciencedirect.com/science/arti...

Hepatocyte mitochondrial NAD+ content is limiting for liver regeneration - Nature Metabolism Modulating mitochondrial NAD+ levels by changing the expression of the mitochondrial NAD+ transporter, SLC25A51, Mukherjee et al. demonstrate that mitochondrial, rather than cytosolic or nuclear, NAD+...

Can one target SLC25A51 the major determinant of the mitochondrial NAD+ pool to improve hepatocyte health and regeneration? www.nature.com/articles/s42...

Here using #genetics proxies and association with measurable GLP-1R dependent variables, the authors dismiss the non-metabolic roles of GLP1R in relevant cardiovascular tissues for GLP-1R dependent cardioprotection diabetesjournals.org/care/article... ada.silverchair-cdn.com/ada/content_...

Genetics of Thyroid Function: Relevance for Biology and Disease Management AbstractContext. Genetic factors are a major contributor to variation in thyroid function. Recent studies have partly identified the responsible common gen

Does the future of managing benign thyroid dysfunction encompass incorporation of #genetics in personalized management of thyroid diseases? academic.oup.com/jcem/advance...

Intestinal TGR5-targeted carrier-drug conjugate improves glycemic control in mice and pigs A nonabsorbable, intestinal TGR5-targeted conjugate was designed to improve glycemic control while reducing systemic toxicity in mice and pigs.

The ongoing allure of intestinally-restricted TGR5 ligands for increasing GLP-1 and the treatment of metabolic disorders #diabetes #obesity here with a non-absorbable carrier drug conjugate www.science.org/doi/10.1126/...

The 100 yr pursuit for non-injectable #insulin ..Here based on mouse and mini pig data, “a skin-permeable polymer may enable non-invasive transdermal delivery of insulin, relieving patients with #diabetes from subcutaneous injections” www.nature.com/articles/s41...

The prevalence of prediabetes is high and has rapidly increased, independent of the degree of obesity, in Finnish children with overweight or obesity - International Journal of Obesity International Journal of Obesity - The prevalence of prediabetes is high and has rapidly increased, independent of the degree of obesity, in Finnish children with overweight or obesity

In Finland #Prediabetes was prevalent in pediatric patients with #obesity and was associated particularly with steatotic liver disease and prevalence increased steeply over time, independent of the degree of obesity www.nature.com/articles/s41...

The consequences of misinformation are real and often tragic #vaccines #measles www.nature.com/articles/d41...

#ENDO2026 Abstract Submissions Are Now Open | Share your research to earn media coverage for your work. Accepted abstracts may be published in a supplement to our Open Access publication, #JES. The deadline is Thursday, January 15: https://bit.ly/49lxDqp #EndoSky @endosocjournals.bsky.social

An update on the Neural Regulation of Blood Glucose in Acute Stress from Professor Stanley @AmDiabetesAssn diabetesjournals.org/diabetes/art...

New insights into islet ER stress responses, proinsulin biosynthesis, ERAD and ERD1 using β-cell-specific Hrd1-KO mice & rodent (and human islet) β-cells treated acutely with HRD1 inhibitor. jci.org/articles/vie...
@jci.org

Seizure recurrence after GLP‐1 receptor agonist initiation in adults with epilepsy Objective To examine whether initiation of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) is associated with seizure recurrence and related outcomes in adults with epilepsy and type 2 diabete...

In adults with a history of seizure disorder in TriNetX, GLP-1 RA initiation was associated with reduced risks of seizure recurrence, hospitalization, and mortality compared with other glucose-lowering therapies onlinelibrary.wiley.com/doi/10.1111/...

Canada’s research and scientific spending is declining relative to other nations, report says Low rate of R&D investment plays key role in productivity crisis, according to Council of Canadian Academies

Canada’s research and scientific spending is declining relative to other nations, Council of Canadian Academies report says, by @ivansemeniuk.bsky.social www.theglobeandmail.com/canada/scien... via @theglobeandmail.com

Rare coding mutations in the glucagon-like peptide-2 pathway are associated with increased risk of binge eating disorders We have previously reported that patients with a history of binge eating disorder or bulimia nervosa are more likely to have rare, damaging mutations …

Does genetic variation in GLP-2R signaling influence the development of binge eating disorders and/or the therapeutic response to GLP-1 medicines? #Bulimia www.sciencedirect.com/science/arti...

Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health - Nature Communications Insulin resistance contributes to cardiometabolic disease, but its genetic basis remains incompletely defined. Here, the authors identify 217 associated loci and highlight potential therapeutic target...

Here the authors reveal precise preventive and therapeutic strategies to ameliorate Insulin Resistance-related cardiometabolic health and longevity www.nature.com/articles/s41...

Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide - Nature Medicine This study provides the first evidence in humans that tirzepatide modulates brain electrophysiology, with changes in low-frequency accumbens power linked to food preoccupation.

How does tirzepatide talk to your brain and quiet food noise? A case report with electrophysiological insights www.nature.com/articles/s41...

Revisiting the traditional paradigms and goals for initial management of #T2D A focus on achievement of #weightloss with cost effective GLP-1 medicines diabetesjournals.org/care/article... ada.silverchair-cdn.com/ada/content_...

Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis - Nature Communications The enteric nervous system integrates microbial cues to regulate gut function. Using an optogenetic gut culture model, authors show lineage- and frequency-specific neuronal control of immune responses...

An optogenetics enabled enteric nervous system epithelium gut organ platform for systematic discovery and mechanistic exploration of functional neuroimmune connections www.nature.com/articles/s41...

NLRP3 inhibition by VTX3232 tempers inflammation resulting in reduced body weight, hyperglycemia, and hepatic steatosis in obese male mice The NLRP3 inflammasome is a key innate immune sensor that orchestrates inflammatory responses to diverse stress signals, including metabolic danger cu…

Preclinical studies highlight the biological rationale for targeting NLRP3 w/wo GLP-1R agonism in inflammatory conditions such as #obesity www.sciencedirect.com/science/arti...