Rama Bhatia

Trade-offs between phage resistance and conjugative ability shape the ecological and evolutionary response of a multidrug resistance plasmid to plasmid-dependent phage Phage therapy is a promising alternative to antibiotics to treat multidrug resistant infections. Plasmid dependent phages (PDPs) are particularly attractive as therapeutics because they can both kill ...

New pre-print www.biorxiv.org/content/10.1...
Plasmid-dependent phage (PDPs) are ubiquitous, but the selective pressures that they impose on plasmids are not well understood. Project led by Daniel Cazares in collaboration with @brockhurstlab.bsky.social!
#phagesky#microsky

🚨 Call for Abstracts! 🚨
Exeter Microbial Genomics Early Careers Symposium 🦠🧬

Present your work, chair a session, win prizes & network!
📅 12 Nov
📍 Penryn Campus
⏰ Submit TODAY by 5pm 👉 linktr.ee/microbesng

#MicrobialGenomics #ECR #MNGPopUp
Organised with @drramabht.bsky.social @exeter.ac.uk

CRISPR system reprograms bacteria to disarm deadly toxin Gene-editing technique disables Shiga toxin genes in <i>E. coli</i>

Scientists have developed a new gene-editing approach that reprograms pathogens to stop producing toxins and instead make a helpful molecule. cen.acs.org/biological-c...

#CRISPR #geneediting #MolecularBiology #MolBiol #microsky

very stimulating blog post for all those who are interested in phylogenetic trees and their construction (without being experts themselves) 👇 great weekend read!
thx andrew @andrewjroger.bsky.social for pointing this out🙏
#MicroSky

Biofilms 11

📢 The full #Biofilms11 programme is now available and is packed with groundbreaking content that will spark collaboration and inspire new ideas💡

🗓️ Join @ukbiofilms.bsky.social and @microbiologysociety.org from 13-15 May 2025 in Cardiff ➡️ tinyurl.com/2karbnht

#biofilms #biofilm #MicroSky

We also have a couple of poster presentations today 255 from @drramabht.bsky.social, 282 from @anna-k-richmond.bsky.social, 062 from Meg Llewellyn and 068 from Jasmine Thomas-Campbell. All cool stuff about defence systems!

At Poster 092 today! Loss of quorum sensing and a promoter region mutation in lung-like environments

@brockhurstlab.bsky.social giving a talk about eco-evolutionary mechanisms of AMR in the AMR session at #Microbio25

Poster A097 tomorrow at #Microbio25!

Research Fellow - Department of Microbes, Infection and Microbiomes - 104952 - Grade 7 To take a lead role in the development and delivery of an MRC funded UK-China research network on antimicrobial resistance epidemiology

A reminder that there just a few days left to apply to work with us as a post doc on DETECTIVE-II. MRC funded project to work on genomics and metagenomics of AMR in China and the UK

edzz.fa.em3.oraclecloud.com/hcmUI/Candid...

glad to be here!

This is a truly incredible resource for anyone working on bacterial genomics. I'm struggling to assemble and organise 1,000 bacterial genomes, and I can’t even begin to fathom handling 2.4 million 🤯

PhD studentship alert!! Two projects available with me fully funded by BBSRC

This one is a collaboration with Dr Michelle Buckner
warwick.ac.uk/fac/cross_fa...

And this one a collaboration with @overtonlab.bsky.social warwick.ac.uk/fac/cross_fa...

Both will be lots of fun! Come & join us 😃

Incredible graphic - the myriad of ways that bacteria defend themselves against antibiotics.

14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell

www.sciencedirect.com/science/arti...

Thank you!

Me too :)

💊GW4 AMR Alliance Newsletter - October 2024 For more details, read the full article by clicking the link below.

Happy to be featured in the GW4Alliance Newsletter this month!

us6.campaign-archive.com?u=bfba6544e4...

Research Assistant - Impact Of Microbe-Pathogen Interactions On The Health Of Individuals With Cystic Fibrosis:Oxford Road

🚨 The Whelan lab is hiring! 🚨 We're looking for a Research Assistant to join our lab at U of Manchester. We're seeking someone with experience in microbiology & microbiome to support our growing group. Note this isn't a postdoc role (though keep 👀 for those announcements soon!) #Microsky 🧪 🧬 💻

Are you a researcher with an interest in #microbiology, #ecology and #evolution? Join our upcoming scientific discussion meeting on the topic of microbial immune systems: ow.ly/fcKR50S89xA

How do interactions in the microbiome shape the evolution of antibiotic resistance in bacterial pathogens? at Queen’s University Belfast on FindAPhD.com PhD Project - How do interactions in the microbiome shape the evolution of antibiotic resistance in bacterial pathogens? at Queen’s University Belfast, listed on FindAPhD.com

Please share: Funded PhD project on the ecology and evolution of antibiotic resistance 🦠🧬🫁 at Queen’s University Belfast.
Application deadline: 21 June
Please 📧 me with any questions, happy to chat!

www.findaphd.com/phds/project...

Wohoo 🎉 🎉Many Congratulations James!!!

SMBE pangenomes meeting details
Dates: 26-28th November 2024.
Location: National Museum of Nature and Science, Ueno Park, Tokyo, Japan.
Abstract submission: 1st June-31st August.
Registration: 1st July-31st October.
See the updated website: smbepangenomes.bacpop.org

Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance - Nature Reviews Microbiology In this Review, Shepherd, Brockhurst and colleagues explore the clinical evidence in support of four major ecological and evolutionary mechanisms of within-patient antimicrobial resistance emergence i...

Thrilled to share our new article now out in Nature Reviews Microbiology! We review how bacterial #AMR evolves within patients during #antibiotic therapy, highlighting the complexity of the problem and how to improve understanding in future work. 1/7 #MicroSky
www.nature.com/articles/s41...

Awesome 👏👏👏 Congratulations Matt!!!

All set for the Pangenomics course by @jomcinerney.bsky.social @physaliacourses.bsky.social
Excited and looking forward to learning a lot from the expert himself!!!

Congratulations Mike!!

Using phage therapy to resensitize P aeruginosa to antibiotics in murine lung infection, featuring @mermanchester.bsky.social’s Rosanna Wright, led by Jo Fothergill www.nature.com/articles/s41...

Excited to share that our official website is now live 🎉🎉 Find out more about our team and our exciting research here sites.exeter.ac.uk/multidefence/

Congratulations Matt!!! Wish I could be there to celebrate your success. Hopefully will see you soon :)

Capsules and their traits shape phage susceptibility and plasmid conjugation efficiency - Nature Communications Bacterial capsules provide protection against the environment, including host immune systems. Authors swap capsule loci in Klebsiella pneumoniae to reveal the role of these sugar coats against plasmid...

Our latest work is finally out!
How #capsule serotypes of #Klebsiella pneumoniae influences #phage adsorption and infection, and #plasmid conjugation efficiency.
Plasmids care about size-phages dont!
Great work led by Matthieu Haudiquet in the lab @epcrocha.bsky.social

doi.org/10.1038/s414...