UC Davis Mouse Biology Program

🫱A new polymer delivery system may allow insulin to be absorbed through the skin and control blood sugar without injections, at least in animal studies! Source: https://www.nature.com/articles/s41586-025-09729-x

In vivo & in silico: Compounds linked to traditional medicine reduced anxiety-, depression-, and pain-related behaviors in mice. Computer modeling suggested key compounds and targets, while mouse studies showed how those predictions played out biologically: https://doi.org/10.100

Turning Back Immune System Aging: A new method instructs liver to pump out specific proteins, effectively hitting the "reset" button on an aging immune system to restore youthful defense capabilities. Source: https://www.livescience.com/health/immune-system/an-experimental-mrna-treatment-counters-i

Turning Back Immune System Aging: A new method instructs liver to pump out specific proteins, effectively hitting the "reset" button on an aging immune system to restore youthful defense capabilities. Source: https://www.livescience.com/health/immune-system/an-experimental-mrna-treatment-counters-i

We’re grateful for another year of collaboration and support. Please enjoy this short thank-you video from the UC Davis Mouse Biology Program (sound on):

National Security Commission on Emerging Biotechnology warns U.S. science is getting outpaced: https://www.fiercebiotech.com/biotech/us-commission-recommends-federal-research-revamp-avoid-losing-global-biotech-edge?utm_medium=email&utm_source=nl&utm_campaign=LS-NL-FierceBiotechResearch&oly_enc

The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine. A quiet change means the government is making fewer bets on long-term science. https://www.nytimes.com/interactive/2025/12/02/upshot/trump-science-funding-cuts.html?unlocked_article_code=1.5k8.aC_b.voYFMu6ICX8W&smid=url-share

Scientists found that HSL not only breaks down fat but also works inside the nucleus of to keep adipose tissue healthy, explaining why people lacking HSL lose fat instead of becoming obese. https://scitechdaily.com/obesity-discovery-

The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio

The FDA has approved Kygevvi (doxecitine + doxribtimine) as the first-ever treatment for Thymidine Kinase 2 Deficiency (TK2d), offering hope to patients with this devastating mitochondrial disease. https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-1st-

Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. https://postly.click/ABY

James D. Watson, part of the team that uncovered the double-helix structure of DNA in 1953 with Francis Crick, Rosalind Franklin and Maurice Wilkins, has died at 97. His work marked a notable moment in biology.
https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n

As oocytes grow, H2A.Z shifts from marking active genes to spreading across broader, silent DNA regions, working hand-in-hand with another modification to support healthy meiosis and prepare the egg’s epigenetic blueprint for early embryonic life. .nature.com/articles/s41594-025-01573-xMore Info:

IMPC Strategic Conference
‘Insights from the Past, Shaping the Future’

Program and key information
👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/

Free Registration
👉https://tinyurl.com/yz7znkde

🎉 Big congrats to Dr. Eric Green for receiving the American Society of Human Genetics Leadership Award — a standing ovation for visionary leadership in genomics! Read About it here: https://www.genengnews.com/topics/omics/eric-green-receives-ashg-leadership-award-to-standing-ovation/

"Animal models provide insights that alternative approaches can’t. A heated debate about which method is better is distracting researchers from doing good science."

https://EcKc5wILd4%3D

MMRRC is in Boston at ASHG for the next 3 days - booth 1327! For more info: https://meetings.ashg.org/event/ASHG25/program/schedule

What Baby KJ’s CRISPR Breakthrough Really Tells Us. Reflections on the balance between hope and realism — new therapies are exciting, but they’re not universal cures yet. Read More: https://www.statnews.com/2025/10/09/crispr-cure-baby-kj-rare-diseases-personalized-gene-editing-drugs/?_hsmi=38470699

Congratulations to Drs. Brunkow, Ramsdell, & Sakaguchi! For More information: https://postly.click/ECH

“...the first step out of the maze for young men begins by reasserting to them the virtue of hard work — an often grueling but indispensable part of finding the right answers in science.”

Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...

Some good research "food for thought... " https://www.nature.com/articles/d41586-025-02920-0?utm_source=Live+Audience&utm_campaign=b2c87a0562-nature-briefing-daily-20250916&utm_medium=email&utm_term=0_-33f35e09ea-49915704

🌟 We’re proud to support the Rare Diseases Are Not Rare! Challenge—working together for faster treatments.
With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge

Over the Last Year! - Mouse Biology Program In this latest episode, we reflect on the past year at the Mouse Biology Program — what we’ve achieved, the challenges we’ve tackled, and how our work is shaping the future of research. From expanding services and strengthening collaborations to pushing innovation in new directions, this conversa...

From expanding services and strengthening collaborations to pushing innovation in new directions, this conversation gives listeners a clear snapshot of where MBP stands today and where we’re headed next. Click Here to Listen: https://mbp.mousebiology.org/news/over-the-last-year/

In this latest episode, we reflect on the past year at the Mouse Biology Program — what we’ve achieved, the challenges we’ve tackled, and how our work is shaping the future of research.

A great question...

https://www.theatlantic.com/health/archive/2025/08/nih-funding-whiplash/683773/?gift=4lmIFlDypD2qizi37OjlOFcAyBgKZPvOqwBmeZV_gRM&utm

Righting the Ship... https://www.nature.com/articles/d41586-025-02331-1.epdf?sharing_token=l7tRdDqzPMtZY_fH3UilNdRgN0jAjWel9jnR3ZoTv0MN1Qa0Vg7jBoDX-os-NGcnreSmdlunxc76Fm4BFTVgIRcWiJXH5_Mm6B0xbQzS9AVWJf16F2hpzcCoBM1I1qXdjXso5QNekkp_M4xECg8pJmszLDG-Y5fzLs2SaPwXEMA%3D

" Read more here: https://www.genengnews.com/topics/translational-medicine/why-we-still-need-animal-research-in-a-world-of-ai-and-organoids/

"To be clear, there is no replacement yet for animal research in biomedical science...it remains to be seen how faithfully these [stem cell] reprogrammed cells and organoids mimic various complex biological processes.

Mice treated with a copper drug repaired faulty brain proteins, reversing Parkinson’s symptoms and offering new hope. Source: https://www.goodnewsnetwork.org/scientists-reverse-parkinsons-symptoms-in-mice-we-were-astonished-by-the-success/

What happens when lifesaving research quietly disappears? A look at critical NIH-funded projects lost to sudden budget cuts: projects.propublica.org/nih-cuts-res...