Paul Knoepfler's Avatar

Paul Knoepfler

@stemcells.bsky.social

Professor at UC Davis studying cancer & stem cell epigenomics. I also do outreach and blog The Niche http://ipscell.com Also stem cell YouTube channel http://cutt.ly/vcsev4J STAT column https://www.statnews.com/category/lab-dish-paul-knoepfler/

3,224 Followers  |  772 Following  |  402 Posts  |  Joined: 20.10.2023  |  1.6674

Latest posts by stemcells.bsky.social on Bluesky

Very odd by DOJ

31.10.2025 01:46 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Preview
Justice Department unexpectedly drops fraud case against Alzheimer’s scientist Decision comes after disclosure of university letter concluding Hoau-Yan Wang did not engage in misconduct

Missed this: it's fine to steal from NIH & conducting research w/out keeping ANY records doesn't meet the definition of misconduct at CUNY.

18 USC 1001 was last seen hiding under a chair at Trump's inauguration.

31.10.2025 01:42 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
Preview
Collateral effects of COVID-19 pandemic control on the US infectious disease landscape Using data from the United States Centers for Disease Control and Prevention (CDC) disease surveillance systems, we sought to quantify the indirect effects of the COVID-19 pandemic, and the possibilit...

The collateral benefits of the Covid pandemic response was a marked decrease in airborne and aerosol-transmitted infections via masking and non-pharmaceutical interventions
@science.org
www.science.org/doi/10.1126/...

30.10.2025 19:02 β€” πŸ‘ 193    πŸ” 57    πŸ’¬ 3    πŸ“Œ 2
Preview
Halloween costumes that really scare scientists - The Niche Some scientists, even on Halloween, might be relatively immune to the fear of things that nonethelessΒ freak out many everyday normal people

Halloween costumes that really scare scientists ipscell.com/2020/10/top-... Some are pretty rough #biology #genetics #humor

30.10.2025 16:59 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Stem cell therapy cost goes up & what to consider looking ahead - The Niche Professor and biologist discusses stem cell therapy cost, the impact of the number of treatments, and other key considerations.

Stem cell therapy cost goes up & what to consider looking ahead. New polling in late 2025. ipscell.com/2025/10/stem... It seems many people are getting 10+ shots #stemcells #stemcell

30.10.2025 16:51 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Exclusive: US military officials required to sign NDAs tied to Latin America mission, sources say U.S. military officials involved with President Donald Trump's expanding operations in Latin America have been asked to sign non-disclosure agreements, three U.S. officials say, a development that raises new questions about a military buildup that Venezuela fears may lead to an invasion.

]Exclusive: US military officials required to sign NDAs tied to Latin America mission, sources say |Reuters]

β€œmilitary officials involved with Trump's expanding operations in Latin America been asked to sign non-disclosure agreements, that raises new questions”

www.reuters.com/world/americ...

29.10.2025 01:04 β€” πŸ‘ 1    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Preview
Weekly reads: FDA warnings on immunotherapy toothpaste & exosomes, upbeat SCID work, animal model alternatives - The Niche immunotherapy toothpaste

Weekly reads: FDA warning on unapproved immunotherapy toothpaste & another on exosomes, upbeat SCID work continues to save lives, animal model alternatives commentary by the wonderful Kent Lloyd ipscell.com/2025/10/week... #stemcells #stemcell

26.10.2025 14:41 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Post image

Pistache trees putting on shows now in Davis, CA

24.10.2025 19:34 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
FDA should act on stem cell supplements as some are actually drugs - The Niche Biologists argues that claims of activation or mobilization by stem cell supplements should trigger drug classifications by the FDA.

ICYMI: Why the FDA show regulate some supposed stem cell supplements as drugs. Hint: these products actually are drugs ipscell.com/2025/10/fda-... #stemcells #stemcell

24.10.2025 15:19 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Post image

Republicans strengthened Medicaid the way Trump just strengthened the East Wing of the White House.

23.10.2025 20:25 β€” πŸ‘ 349    πŸ” 87    πŸ’¬ 16    πŸ“Œ 2
Man sitting on couch with head in hands with therapist holding clipboard reading "Mariners fan 25 years YIKES"

Man sitting on couch with head in hands with therapist holding clipboard reading "Mariners fan 25 years YIKES"

DSM-5 Now Includes Mariners Fanhood as a Legitimate Form of Depression: tinyurl.com/5e8a65zt

22.10.2025 04:01 β€” πŸ‘ 313    πŸ” 73    πŸ’¬ 11    πŸ“Œ 27
Preview
FDA should act on stem cell supplements as some are actually drugs - The Niche Biologists argues that claims of activation or mobilization by stem cell supplements should trigger drug classifications by the FDA.

FDA should act on supposed stem cell supplements as some are actually drugs and make medical claims. Some also contains peptides that are drugs ipscell.com/2025/10/fda-... #stemcells #stemcell

23.10.2025 19:22 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

it’s pretty incredible how prop 50 in California is literally polling ahead of Kamala’s performance right now. turns out there are almost no libs who support unilateral disarmament in the face of GOP trying to rig elections, and great to see Virginia joining the fight

23.10.2025 15:51 β€” πŸ‘ 158    πŸ” 30    πŸ’¬ 3    πŸ“Œ 2
Preview
Some skepticism as Shift Bioscience reports secret purported rejuvenation gene SB000 in preprint - The Niche Professor discusses a rejuvenation gene, which remains a secret, that reportedly de-ages somatic cells without reprogramming them.

ICYMI: Some skepticism as Shift Bioscience reports secret purported rejuvenation gene SB000 in preprint ipscell.com/2025/06/some... As best as I can tell, we still don't know what this amazing gene is #stemcells #stemcell

23.10.2025 01:29 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Preview
Storer Lectureship - Misconduct in Neuroscience Research: Problems and Solutions Charles Piller writes investigative stories for Science.

Northern Californians: I’ll be giving the Storer Lecture at UC Davis on Oct. 23, at 4pm. It will cover my investigative findings in Science and my in book β€œDoctored” about Alzheimer’s research misconduct. I’d be delighted to see you in person or via zoom. biology.ucdavis.edu/events/store...

07.10.2025 20:27 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Now do the NIH.

22.10.2025 23:13 β€” πŸ‘ 17    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
StephenMiller calling description of our story "abject lies."

StephenMiller calling description of our story "abject lies."

Yesterday, Stephen Miller questioned details re 170+ Americans detained by immigration agents.

β€œAbject lies,” he wrote.

Here’s the thing: We tracked, catalogued, and compiled every one of those 170+ cases.

Because...we do our homework.

propub.li/4o2eeiL

22.10.2025 00:50 β€” πŸ‘ 1507    πŸ” 390    πŸ’¬ 33    πŸ“Œ 8
Post image

The White House is asking people not to share pictures of the East Wing because it’s even worse today.

21.10.2025 22:54 β€” πŸ‘ 30040    πŸ” 16323    πŸ’¬ 2408    πŸ“Œ 1709
Preview
Anti-science bills hit statehouses, attacking longstanding public health protections More than 420 anti-science bills attacking longstanding public health protections – vaccines, milk safety and fluoride – have been introduced in statehouses across the U.S. this year.

An AP investigation found that more than 420 anti-science bills attacking longstanding public health protections – vaccines, milk safety and fluoride – have been introduced in statehouses this year, part of a campaign to enshrine a conspiracy theory-driven agenda into law. https://to.pbs.org/43dxCkD

21.10.2025 20:31 β€” πŸ‘ 332    πŸ” 217    πŸ’¬ 25    πŸ“Œ 33

The Louvre thieves should just say they're using the pieces to train their AI algorithm and it should all be good

20.10.2025 12:27 β€” πŸ‘ 72    πŸ” 10    πŸ’¬ 3    πŸ“Œ 0
Preview
Weekly reads: odd $405 Stanford longevity AI thing, bemdaneprocel for Parkinson’s, & 'not just some hippie pursuit' - The Niche Biologist discusses the week's news in regenerative medicine including a $405 Stanford AI longevity thing and bemdaneprocel for Parkinson’s.

ICYMI: Weekly #regenerative reads: odd $405 Stanford longevity AI thing, bemdaneprocel for Parkinson’s, & β€˜not just some hippie pursuit’ ipscell.com/2025/10/week... #stemcells

20.10.2025 18:13 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Weekly reads: odd $405 Stanford longevity AI thing, bemdaneprocel for Parkinson’s, & 'not just some hippie pursuit' - The Niche Biologist discusses the week's news in regenerative medicine including a $405 Stanford AI longevity thing and bemdaneprocel for Parkinson’s.

Weekly reads: odd $405 Stanford longevity AI course thing, encouraging longer-term data on trial of bemdaneprocel cell therapy for Parkinson’s, & #stemcell quote of the year? β€˜not just some hippie pursuit’ ipscell.com/2025/10/week... #stemcells

19.10.2025 14:38 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Post image Post image

2 more recent birds: fairly common around here in fall but still showy, Spotted Towhee and relatively rare, dramatic Phainopepla

19.10.2025 20:25 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Weekly reads: odd $405 Stanford longevity AI thing, bemdaneprocel for Parkinson’s, & 'not just some hippie pursuit' - The Niche Biologist discusses the week's news in regenerative medicine including a $405 Stanford AI longevity thing and bemdaneprocel for Parkinson’s.

Weekly reads: odd $405 Stanford longevity AI course thing, encouraging longer-term data on trial of bemdaneprocel cell therapy for Parkinson’s, & #stemcell quote of the year? β€˜not just some hippie pursuit’ ipscell.com/2025/10/week... #stemcells

19.10.2025 14:38 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Video thumbnail

This is what democracy looks like. #NoKings

18.10.2025 23:22 β€” πŸ‘ 89361    πŸ” 29076    πŸ’¬ 2327    πŸ“Œ 1870
Post image

This is a great ending to a terrible story #Indiana #IU #Purdue #fascism

18.10.2025 17:15 β€” πŸ‘ 36    πŸ” 18    πŸ’¬ 2    πŸ“Œ 1
Post image

Red-shouldered hawk at sunrise in Davis, CA

18.10.2025 18:22 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Preview
FDA secures major win as SCOTUS lets stem cell clinic ruling stand - The Niche Stem cell biologist discusses how SCOTUS declining to review FDA court victory on clinics affirms fat cells as drugs & implications.

FDA secures major win as SCOTUS lets stem cell clinic ruling stand ipscell.com/2025/10/fda-... #stemcells #stemcell RFK Jr.

17.10.2025 16:19 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
Preview
Polling on stem cell therapy cost: what did you pay & how many did you get? - The Niche Professor discusses and takes polls on stem cell therapy cost including cost per injection and how many injections readers have gotten.

ICYMI: last chance to participate in our polls on how much stem cell therapy costs and how many you got. Please head over as it only takes a few seconds. ipscell.com/2025/10/poll... #stemcells #stemcell

17.10.2025 17:04 β€” πŸ‘ 3    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
Preview
Exclusive | Trump Administration Meets With More Colleges About β€˜Compact’ After Rejections The meeting was to gather input from the schools about the proposal, a White House official said

Exclusive: The Trump administration is reaching out to more universities about its funding-advantage proposal after several early invitees rejected it.

17.10.2025 18:05 β€” πŸ‘ 32    πŸ” 20    πŸ’¬ 11    πŸ“Œ 17

@stemcells is following 20 prominent accounts