Paul Knoepfler

Wyoming stem cell bill is latest risky, anti-FDA state legislation - The Niche Stem cell biologist discusses a new Wyoming stem cell bill that is latest anti-FDA state legislation that poses risks to consumers.

Wyoming stem cell bill is latest risky, anti-FDA state legislation ipscell.com/2026/02/wyom... the so-called Stem Cell Freedom Act is a direct challenge to the FDA #stemcells #stemcell Joins other states like Florida but with some key differences

This cannot be something a civilian law enforcement agent is allowed to wear in the US — and an agency that has a culture that tolerates this cannot be saved.

Weekly reads: human SCBEM framework, reporter self-injects peptides, ASD, NAMs - The Niche Scientists sometimes disagree about research including not just what data might mean, but also what kinds of rules there should be about research like stem cell-based embryo models (SCBEM). It makes s...

Weekly #regenerative & #stemcell reads: proposed human SCBEM framework, reporter self-injects peptides, ASD, organoids & NAMs ipscell.com/2026/02/week...

Weekly reads: human SCBEM framework, reporter self-injects peptides, ASD, NAMs - The Niche Scientists sometimes disagree about research including not just what data might mean, but also what kinds of rules there should be about research like stem cell-based embryo models (SCBEM). It makes s...

Weekly #regenerative & #stemcell reads: proposed human SCBEM framework, reporter self-injects peptides, ASD, organoids & NAMs ipscell.com/2026/02/week...

Judge Orders Release of 5-Year-Old Whose Detention Drew Outrage

His brief but fiery ruling chastised the government’s “ignorance of an American historical document called the Declaration of Independence”

www.nytimes.com/2026/01/31/u...

Basically, we’re past Orban.

His Stanford colleague and disinformation super spreader Ioannidis started these myths nearly 6 years ago.

Discussed in this novel.

sciencebasedmedicine.org/what-exactly...

I'm at the Willard Hotel where I've been denied entry and kicked out of the Reclaiming Science event with NIH director Bhattacharya & other top agency leaders.

@jocelynkaiser.bsky.social and I registered for the event months ago yet were told capacity was full, even as they let in dozens of others.

In support of the Roman Reed Spinal Cord Injury Research Act ipscell.com/2026/01/in-s... #stemcells #stemcell

I let mine expire more than a year ago and don't miss it much. I occasionally glance at the op-ed page and that is often enough to make me not regret it.

The @washingtonpost.com, OTOH...not so much.
"Ilhan Omar should not have to fear for her safety to espouse her views, even if they are extreme." Less extreme (albeit in the other direction) than those of this Administration, the feet of whose boss the Post's owner is busy licking.

I don't know if it makes a difference, but we're actively trying to spend much less on Amazon and looking for other options...

In support of the Roman Reed Spinal Cord Injury Research Act ipscell.com/2026/01/in-s... #stemcells #stemcell

Online now! A comprehensive overview of pluripotent stem cell lines for clinical use.166 clinical hPSC lines available for licensing and distribution, including 11 used in clinical trials, with information on consent, regulation, and characterization. https://ow.ly/tQ2j50XMw30

ISSCR

In addition to not using journal articles, FDA commish and division heads need to disclose their meetings with podcasters, promoters and booking agents.
Transcripts of the commissioner's interviews should be posted on the FDA website.

Thanks. I think this is going to be very messy & inconsistently applied.

To Holly, et al. one thought about the plausible mechanisms path is that it seems a better fit for gene therapies (or combo cell-gene therapies) than for just cell therapies, but it applies to just cell therapies too, right?

Great piece. It resonates with mine on CGT "flexibilities" from last week www.statnews.com/2026/01/20/f... The FDA is kind of doing its new science policy by press release on these related fronts.

Fun to get some pics of a Tropical Kingbird here in Sacramento, a bird that's usually in Mexico and southern Arizona

Weekly reads: NIH fetal tissue research ban, hESCs likely next, retraction spike, FDA CGT flexibility - The Niche Biologist discusses recent news and research related to regenerative medicine including a fetal tissue research ban on NIH funding.

Weekly #regenerative reads: NIH fetal tissue research ban, hESCs likely next, retraction spike or just more awareness, more on "new" FDA CGT flexibility ipscell.com/2026/01/week... #stemcells

ICE supporting Republicans are claiming ICE shooting was justified due to the victim being armed. So “2nd Amendment is absolute” crowd is now applauding killing someone for exercising his 2nd Amendment rights? I would call them hypocrites but that would be redundant. And useless. #ProudBlue

Yeah, especially when you combine it with 4-5% paylines, etc.

Unfilled vacancies have depleted NIH advisory councils, key players in grant approvals Only one new member was added to NIH advisory councils, which make final recommendations on grant awards, during President Trump's first year

It seems like this is probably just another way to interfere with/slow down NIH funding research www.statnews.com/2026/01/22/n...

Trump administration drops legal appeal over anti-DEI funding threat to schools and colleges The Trump administration is dropping its appeal of a federal court ruling that blocked a campaign against diversity, equity, and inclusion threatening federal funding to the nation’s schools and colle...

Trump administration drops legal appeal over anti-DEI funding threat to schools and colleges. This leaves in place a federal judge's ruling that the anti-DEI effort violated the First Amendment and federal procedural rules. (Via AP) apnews.com/article/dei-... #ncpol #nced

During the last ACIP meeting, Milhoan openly wondered why the yellow fever vaccine (a live attenuated vaccine) was one dose while the Hepatitis B (recombinant DNA) is three doses.

He said this in a public meeting recorded for all eternity.

www.youtube.com/live/kUgXRUp...

Stem cells for stroke hype awardee 10 years ago now tells a cautionary tale - The Niche Biologist discusses a previous stem cells for stroke headline that won an award for hype; nothing came of the stem cell trial.

Stem cells for stroke hype awardee 10 years ago now tells a cautionary tale ipscell.com/2026/01/stem... A typical hyped early trial (or results outside of any trials) sparks buzz early and then goes nowhere.

Stem cells for stroke hype awardee 10 years ago now tells a cautionary tale - The Niche Biologist discusses a previous stem cells for stroke headline that won an award for hype; nothing came of the stem cell trial.

Stem cells for stroke hype awardee 10 years ago now tells a cautionary tale ipscell.com/2026/01/stem... A typical hyped early trial (or results outside of any trials) sparks buzz early and then goes nowhere.

Fluffy brown tabby cat lies on her side atop a treadmill

Nala has already given up on her New Year’s resolutions.

YouTube video by Parmin Sedigh Stem Cell Clinics vs. Clinical Trials: Ask a Stem Cell Scientist #1

New short collaborative video on YouTube with great student Parmin Sedigh on the differences between #stemcell clinical trials vs stem cell clinics www.youtube.com/shorts/RMql-... #stemcells

Weekly reads: FDA politics, Lineage Cell update, tuft cells & cancer, neuron mitochondrial transfer, dead celeb genomics - The Niche Stem cell biologist discusses recent news including FDA politics, Lineage Cell update, tuft cells & cancer, & neuron mitochondrial transfer.

ICYMI: Weekly regenerative reads: FDA politics, Lineage Cell update, tuft cells & cancer, neuron mitochondrial transfer, dead celeb genomics ipscell.com/2026/01/week...