John De Vos

Nature and Science journalists denied entry to event featuring NIH Director

😂

I love this!

Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues We developed a bioprinting strategy that turns living cells into cell-only bioinks, enabling light-based 3D bioprinting of tissues at native, ultrahigh cell densities (up to ∼109 cells mL−1) to rapidl...

A scaffold-free bioprinting approach achieves physiological cell densities, and is used to print in vitro models of heart and liver structures, and neural circuits #NBThighlight www.cell.com/cell/fulltex...

AI companies will fail. We can salvage something from the wreckage | Cory Doctorow AI is asbestos in the walls of our tech society, stuffed there by monopolists run amok. A serious fight against it must strike at its roots

[AI companies will fail. We can salvage something from the wreckage | AI (artificial intelligence) |The Guardian]

“AI is asbestos in the walls of our tech society, stuffed there by monopolists run amok. A serious fight against it must strike at its roots“

www.theguardian.com/us-news/ng-i...

CD19 CAR T-Cell Therapy for Autoimmune Hemolytic Anemia | NEJM In patients with autoimmune hemolytic anemia (AIHA), the risk of relapse is high owing to persistent autoreactive B-cell activity. Multirefractory AIHA is a more advanced stage of disease that is d...

Another major triumph for a refractory autoimmune disease—hemolytic anemia—through engineered T cells
@nejm.org
nejm.org/doi/full/10....

Ludovic Vallier, Stem Cell Reports Associate Editor, is attending Biotherapy Days 2026 in Toulouse, France 28-30 January 2026. Connect with him to discuss whether your research is a fit for publishing in Stem Cell Reports!

Bar graph showing global ocean heat content change in the upper 2000 m from the late 1950s through 2025. There is a long-term warming in the time series, which is using IAP/CAS data.

2025 was the hottest year on record for ocean heat content. Unfortunately, we now say this every year. 🥹

"In addition to setting a new record in 2025, the global
ocean continues to show sustained and intensified warming."

+ #OpenAccess Study: doi.org/10.1007/s003...
+ Data: www.ocean.iap.ac.cn

Other data regarding #CARTCell treatments in France. Interesting!

Source : buff.ly/k3Z9kDv

Number of #CARTCell treatments in France : rapidly increasing.

Source : buff.ly/k3Z9kDv

News: Off-the-shelf CRISPR CAR-T tackles brain tumours - CRISPR Medicine A first-in-human, phase I trial tested intrathecal delivery of CRISPR-Cas9-edited, allogeneic IL-13Rα2 CAR-T cells in five people with recurrent high-grade glioma. The single-centre study reports…

Solid tumor, allogeneic #CART alert 📣 : encouraging results from a phase I study using allogeneic IL-13Rα2 CAR-T cells in five people with recurrent high-grade glioma.

buff.ly/Q8RBlx4

CARsgen Submits Dual IND Applications for Allogeneic BCMA CAR-T Product CT0596 SHANGHAI,Dec. 28, 2025 /PRNewswire/ -- CARsgen Therapeutics Holdings Limited (Stock Code: 2171.HK), a company focused on developing innovative CAR T-cell therapies, announced that it has submitted

Allogeneic #CARTCells in phase Ib/II clinical trials in China for the treatment of relapsed/refractory multiple myeloma (R/R MM) and primary plasma cell leukemia (pPCL). Phase I study showed interesting results.

buff.ly/SKuRXC9

Science in 2050: the future breakthroughs that will shape our world — and beyond Nuclear fusion. People on Mars. Artificial general intelligence. These are just some of the advances that could come by the mid-century mark.

"There’s a good likelihood that by 2050, all scientific research will be done
by superintelligent AI rather than human researchers,” Bostrom said in an e-mail. “Some humans might do science as a hobby, but they wouldn’t be making any useful contributions.”

The science of 2025

buff.ly/nElWVRL

Modelling late gastrulation in stem cell-derived monkey embryo models - Nature An optimized 3D culture system enabled a stem cell-derived monkey blastoid to develop to day 25, recapitulating key events of primate late gastrula and demonstrating notable similarity to natural…

Monkey pluripotent stem cells-derived blastoids mature in vitro in 3D into Carnegie stage 8-9 (late gastrulation) embryos. Spectacular progress to study primate embryonic development.
buff.ly/IiFHeNU

A phase II trial using #CART cells against a solid tumor (glioblastoma).
T-MAXIMUM Pharmaceutical announced that its proprietary allogeneic B7-H3–targeted CAR-T therapy, MT027, has received FDA IND clearance.
buff.ly/wiGPeyR

Modeling human embryo implantation in vitro: building a receptive endometrium and its interaction with blastoids (“synthetic embryos”). A remarkable achievement!
buff.ly/eZtS5NG

Kyverna to take autoimmune CAR-T to FDA after success in stiff person syndrome trial Kyverna Therapeutics' CAR-T therapy succeeded in a key study in stiff person syndrome, a rare autoimmune disorder that leads to painful muscle spasms and stiffness.

Kyverna to take autoimmune CAR-T to FDA after success in stiff person syndrome trial.
#CARTCells #Autoimmune disease

Un petit enfant s'approche de son père scientifique qui travaille sur un grand appareil étrange. Son visage est collé à un tube d'observation. « Tu attends Noël avec impatience, papa ? » demande l'enfant. « Oui », répond le scientifique en se retournant, « c'est exactement ce que je fais », puis il ajoute : « Merci pour les chaussettes ». Le tube d’observation dans lequel il regarde franchit la bordure de la case de la bande dessinée, traverse une machinerie complexe et permet au scientifique de voir dans la case suivante : Légende : 25 décembre. Une scène de Noël. L'enfant et son père scientifique ouvrent leurs cadeaux devant un sapin de Noël. Le père vient de déballer des chaussettes.

Le samedi soir, il est réjouissant – voire emballant – de poster du Tom Gauld www.tomgauld.com (description et traduction en cliquant sur ALT).

Holy crap!!

Venez découvrir en ce mois de décembre la serre à cactées du Jardin des Plantes de MONTPELLIER.
Attention, vous devez vous inscrire pour y participer.

En ce mois de décembre, laissez vous guider par la magie du Jardin des Plantes de Montpellier : un écrin de nature à découvrir au fil de nos visites....

Early in vivo CAR-T results like Kelonia's elicit excitement across the field A single, ready-made infusion got rid of any detectable cancer cells in four multiple myeloma patients in Australia, Kelonia Therapeutics reported as part of its first clinical trial readout.

Early in vivo #CART results like Kelonia's elicit excitement across the field.
buff.ly/70ZzqzS

Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia | NEJM CD7 is an attractive target for chimeric antigen receptor (CAR) T-cell therapy in relapsed or refractory T-cell acute lymphoblastic leukemia (ALL). Supportive results of first-in-human studies of b...

Allogeneic anti-CD7 #CARTCells for relapsing T-ALL eradication prior to hematopoietic allograft!

Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia | New England Journal of Medicine buff.ly/7jYX07o

La révolution de l’immunité ancestrale : quand nos défenses sont un héritage des bactéries De récents travaux font état de nombreux éléments du système immunitaire retrouvés à la fois chez l’homme et les bactéries. Ces protéines ou domaines protéiques ont été élaborés chez les micro-organis...

On découvre que l'immunité existe depuis les bactéries. Elle pourrait amener à redéfinir ce qu’est un être vivant, puisqu'elle distingue de manière universelle le soi du non-soi. Très bel article dans @lemonde.fr

www.lemonde.fr/sciences/art...

Every single person working today in every branch of cell and gene therapy - viral, nonviral, editing, transgenesis - owes a deep debt of gratitude to Dr. High.

Our meeting has now come to a close. Many thanks to all attendees and our outstanding speakers. See you in Paris in 2027!
#FSSCR2025
Lyon, Nov 17–19, 2025

The FSSCR Best Short Talk and Best Poster prizes — sponsored by the Fondation Marion & Elisabeth Brancher and Development — were awarded by Anne Camus and @crougeulle.bsky.social. Bravo to the winners!

#FSSCR2025
Lyon, Nov 17–19, 2025

new paper by Sean Westwood:

With current technology, it is impossible to tell whether survey respondents are real or bots. Among other things, makes it easy for bad actors to manipulate outcomes. No good news here for the future of online-based survey research

Such a treat to be sitting in the room where @denisduboule.bsky.social is giving a talk @fsscr.bsky.social meeting in Lyon! Exciting and insightful science ahead 🤯🤘

🙏🏼 A wonderful meeting indeed. Full of great science and energy 👏 @fsscr.bsky.social