Ed Feil

Bacteria chromosomes contain Genomic Islands that provide virulence, antibiotic resistance, MGE-defence,... They transfer between cells, but the mechanism of most remains elusive.

Here we explore the conjugative capacity of these mysterious Genomic Islands.

www.biorxiv.org/content/10.6...

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These plasmids have emerged through hybridisation of co-circulating plasmids carrying either resistance or virulence genes. ‘Convergence’ may be a common phenomenon even in ‘One Health’ settings. Variation in these plasmids is also structured according to geographical and ecological source.

We describe an analysis of plasmids from klebsiella pneumoniae recovered from diverse human, animal and environmental settings in Italy and Thailand. We found multiple isolates from neighbouring markets in Thailand that harbour plasmids carrying both antibiotic resistance and virulence genes.

Convergence and global molecular epidemiology of Klebsiella pneumoniae plasmids harbouring the iuc3 virulence locus: a population genomic analysis Klebsiella pneumoniae is an important pathogen of humans and animals. In the past five years, increasing reports of convergent strains that carry both…

It has been a long road, but our paper on Klebsiella plasmids is finally out in Lancet Microbe. Thanks to all co authors but especially Marjorie Gibbon and Natacha Couto www.sciencedirect.com/science/arti...

A teal flyer for a PhD opportunity to investigate how warming may change antimicrobial resistance. The project will use experiments on Klebsiella bacteria to answer questions about how temperature affects their response to antibiotics, plasmid transfer, and fitness costs. The research involves microbiology lab work, bioinformatics, and mathematical modeling. The flyer includes contact details for Dr. Daniel Padfield and the logos of the sponsoring institutions.

I have an MRC-funded PhD project available (www.exeter.ac.uk/study/fundin...) on how warming will change the problem of AMR. Join a small and friendly group (padpadpadpad.netlify.app/about) in (sometimes) sunny Cornwall. 🧪🦠 #microsky

Please share the ad below with anyone who may be interested.

You were missed!

Congratulations Rachel!

Schematic of the key prediction tested in this work. As the transversion (Tv) mutation bias of WT E. coli is shifted away from the ancestral bias, the resulting distribution of fitness effects (DFE) is predicted to change. Specifically, it should shift left with a bias reinforcement, with a lower fraction of beneficial mutations. In contrast, reversing the ancestral bias is predicted to cause right-shifted DFEs with higher proportions of beneficial mutations.

Mutations generate variation, critical for #evolution, but #MutationBias restricts the choice of mutation type. @deepaagashe.bsky.social &co use #Ecoli strains with different mutation biases to show that changing an old bias should yield more beneficial mutations @plosbiology.org 🧪 plos.io/46LjCRt

Research Associate in Candida One-Health genomic epidemiology - University of Bath - job portal | jobs.myScience Job title Research Associate in Candida One-Health genomic epidemiology

Our JPIAMR grant (led by @edfeil.bsky.social) is ramping up, and Bath are looking for a research associate to work on Candida epidemiology for this project. Come work with us! www.myscience.org/jobs/id31031...

www.bath.ac.uk/jobs/Vacancy...
Post doc available to work on Candida genomics with me at the Milner Centre for Evolution (U Bath, UK) as part of the JPIAMR funded project Fugaci www.jpiamr.eu/projects/fug...
For queries, email me!

Great news. If the squad looks a bit broken right now, this means it'll Zu bi mended.

Mobile integrons encode phage defense systems Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...

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Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉

Short 🧵
www.science.org/doi/10.1126/...

Antimicrobial effects, and selection for AMR by non-antibiotic drugs in a wastewater bacterial community

by @aprilhayes.bsky.social, @edfeil.bsky.social, @willhgaze.bsky.social, @profjrsnape.bsky.social, @ecehh.org et al.

www.sciencedirect.com/science/arti...

PhD on C.diff epidemiology with me and Barbara Kasprzyk-Hordern to join the new centre cwbe.ac.uk @bathchem.bsky.social www.findaphd.com/phds/project...

The website for our new centre of excellence in water-based early-warning systems for health protection is now live : cwbe.ac.uk follow us at @cwbe.bsky.social

Indeed

An advert for a PhD investigating how and why temperature may alter the ecology and evolution of antibiotic resistance.

I'm advertising a PhD studentship (open to international students) on understanding how temperature may alter the ecology and evolution of AMR. Might suits someone with a microbiology/wet lab background who wants to expand into ecoevo. Or vice versa! But interest more important than experience.

New graph algorithms for analysis of the genomes and pangenomes of bacteria and their mobile elements. at University of Bath on FindAPhD.com PhD Project - New graph algorithms for analysis of the genomes and pangenomes of bacteria and their mobile elements. at University of Bath, listed on FindAPhD.com

I'm advertising a PhD studentship (open to international students) working on long read pangenome / assembly algorithms in bacteria. Would suit someone with maths/compsci/coding background. Aptitude + interest more important than experience.
Details here:
www.findaphd.com/phds/project...

Amazing!

Hi. Thought it was time to join the grown-ups!