Vincent Marcangeli

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Our latest review is out now in @jphysiol.bsky.social

The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings

Great team effort 🙌 @grithhojfeldt.bsky.social, Christian Hoegsbjerg, Arvind von Keudell
@ismcopenhagen.bsky.social

doi.org/10.1113/JP28...

Perspectives on the interpretation of mitochondrial responses during skeletal muscle disuse‐induced atrophy Abstract figure legend Common human and rodent muscle disuse models and associated changes in skeletal muscle mitochondrial function; respiration, redox stress and apoptotic cell death. I–V, complexe...

Perspectives on the interpretation of mitochondrial responses during skeletal muscle disuse-induced atrophy
physoc.onlinelibrary.wiley.com/doi/10.1113/...

Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...

Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes

Our lab is excited to be a part of this enormous $23.8 million 'MitoRevolution' initiative led by Ana Andreazza, Scientific Director of Mito2i, and colleagues. We will be investigating the potential for mitochondrial transplantation in preclinical models of muscle disorders.

www.mitoinnovation.com

Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy Abstract figure legend This study investigated the effects of volitional exercise on muscle health in the more severe D2.mdx model of Duchenne muscular dystrophy (DMD). We showed that 8–10 weeks of a...

physoc.onlinelibrary.wiley.com/doi/full/10....

First map of human brain mitochondria is ‘groundbreaking’ achievement Nature - Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

Scientists have created the first map of mitochondria throughout the entire brain

https://go.nature.com/4c8CLNM

Here comes the sun: the central role of human and clinical physiology in the era of multi‐omics and inter‐organ crosstalk Click on the article title to read more.

Here comes the sun: the central role of human and clinical physiology in the era of multi-omics and inter-organ crosstalk | J Physiol

physoc.onlinelibrary.wiley.com/doi/full/10....

A human brain map of mitochondrial respiratory capacity and diversity - Nature The ability to physically partition the human brain at a spatial resolution comparable to neuroimaging methods enabled the development of a brain-wide atlas of mitochondrial content, specialization an...

www.nature.com/articles/s41...
A human brain map of mitochondrial respiratory capacity and diversity

2 new teaching focused tenure track faculty positions in my dept.

careers.uoguelph.ca/job/Guelph-A...

careers.uoguelph.ca/job/Guelph-A...

Muscle fibroblasts and stem cells stimulate motor neurons in an age and exercise‐dependent manner Muscle biopsies were taken from males and females differing in age and exercise habits. Mononucleated cells were isolated and purified into muscle stem cells (MuSC) and muscle fibroblasts (FIB). Neur....

Out in this month's issue of Aging Cell. Motor neurons do better in the presence of primary human muscle cells from older exercisers vs non-exercisers.
🙏to @lundbeckfonden.bsky.social for the Ascending Investigator grant 4 years ago to see this work through
doi.org/10.1111/acel...

Congratulations, well deserved !

Sedentary death syndrome - PubMed Sedentary death syndrome (SeDS) is a major public health burden due to its causing multiple chronic diseases and millions of premature deaths each year. Despite the impact of physical inactivity, very...

« Use of sedentary subjects as the control group has led to potentially misleading interpretations. If physically active individuals were designated as the control group, a different interpretation would have been drawn ».

21-year-old gem.

pubmed.ncbi.nlm.nih.gov/15317985/

Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians - PubMed Physical function declines with aging, yet there is considerable heterogeneity, with some individuals declining very slowly while others experience accelerated functional decline. To gain insight into...

New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions: pubmed.ncbi.nlm.nih.gov/40059508/

Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance - Nature Communications Here they use single nuclei RNA-seq to identify transcripts in skeletal muscle that maintain the neuromuscular junction, both under normal and denervated conditions, which allows them to characterize ...

Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance

www.nature.com/articles/s41...

Where can I sign to train and do OXPHOS analysis on nonagenarians ? 🙌

Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men Cefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanis...

Excited to share our latest paper, out in
@cp-cellrepmed.bsky.social, investigating the impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men. Spearheaded by M Cefis & V Marcangeli
www.cell.com/cell-reports...

Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca2+ handling across the adult lifespan in men Cefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanis...

When studying mitochondria, it is essential to consider the impact of physical activity. Some findings attributed to 'aging' might actually be the result of decades of physical inactivity. ⬇️

www.cell.com/cell-reports...