Ed Huttlin

This morning’s course on studying protein-protein interactions is well on its way at #USHUPO2026! I just wrapped up my talk on AP-MS, and now Lan Huang is talking about crosslinking MS. This afternoon Ling Hao will be talking about proximity labeling as well. @us-hupo.org

Applications are now open for @olgavitek.bsky.social 's May Intitute on computation and statistics for mass spectrometry and proteomics at @northeasternu.bsky.social !

--> computationalproteomics.khoury.northeastern.edu

Unexpected Kid Math Question: how many digits of pi do you need to look at to find the series “67”?

Answer: 100

If you’ve been wondering, you’re welcome!

Trombone next to a music stand

Christmas concert season is here! Tonight I played a concert with the New England Brass Band.

I am looking for a PostDoc to join my group at Genentech to drive the development of proteomics technologies to fuel target and therapeutic discovery and development. Check out the link below!

careers.gene.com/us/en/job/20...

US HUPO - Computational Proteomics Award

Congratulations to Bill Noble on receiving the 2026 Gil Omenn Computational Proteomics Award from US HUPO!
us-hupo.org/Computationa...

US HUPO - Distinguished Contribution Award

Congratulations to Mike MacCoss on receiving the Donald F. Hunt Distinguished Contribution in Proteomics Award from US HUPO!
us-hupo.org/Distinguishe...

If you’re at #HUPO2025, be sure to stop by my poster and learn about the latest developments in the BioPlex project!

#HUPO2025 I Our CTDP poster was very well-received! Thank you all for coming! It is free to join CTDP! If you are interested in learning more about #topdownproteomics, please join our talks tomorrow 😀❤️ @proteoforms.bsky.social @nlkproteomics.bsky.social @edhuttlin.bsky.social

Kudos to the organizers (Jennifer Geddes-McAlister, @mlaval6.bsky.social, Marie Brunet) for arranging snow to coincide with the start of HUPO 2025 in Toronto!

I’m at the airport a and ready to fly to Toronto for this year’s HUPO conference. I’m looking forward to talking about AP-MS tips and tricks at tomorrow’s pre-conference workshop on protein-protein interactions and sharing our latest BioPlex results in a poster on Wednesday!

We are ready for Halloween!

Check out this thread from @haopengxiao.bsky.social on his recent paper! I’m happy I was able to help out on what has turned out to be a really cool story.

Hey @haopengxiao.bsky.social - it’s great to see you on BlueSky!

Could your new account be a sign you might have something cool to announce soon???? ;-)

Post-Translational Modifications Remodel Proteome-Wide Ligandability Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

And although it’s important to acknowledge specific COI, like industry-sponsored research, that isn’t the whole story. In truth, we all share a universal COI, which is that our career advancement - the next degree, job, grant, promotion, etc. - depends on producing “good” results.

Yeah - that’s really my point. COI discussions tend to focus on private funding, but I think from the standpoint of undue external pressure to produce results, public funding isn’t all that different.

“Revolutionary Science Comes from Unexpected Angles”

Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...

than it is already.

It’s also worth noting that public funding can present its own issues. When it’s very competitive to get and keep public funding, that also creates pressure on researchers to produce impressive results. With paylines at the NIH potentially dropping to ~5% in the coming years, this will be even worse

If your concern is with private funding of science in general, I suppose there’s room for debate. But as federal funds for science are cut in the US, private funding will be increasingly important. For me, now that Trump has cut all federal funding to Harvard, private funding is keeping us afloat.

I’m not sure I understand what you’re seeking here either. If the issue is transparency, each of the PI’s above has been open about their collaborations with industry - enough so that they’re easily recognizable from the logos you display and your joke works.

Not really an overstatement to say that the test of a free society is whether or not comedians can make fun of the country's leader on TV without repurcussions.

If you’re at #ASMS2025, stop by the Protein-protein and Protein-ligand Interactions section this afternoon and hear how we are leveraging our BioPlex network and AlphaFold structural models for drug discovery!

If you're going to #ASMS2025, don't miss these Gygi lab presentations! You'll learn about TMT, chemoproteomics, GoDig for targeted proteomics, leveraging BioPlex interactions for drug discovery, new instrumentation, and more! @amandalsmythers.bsky.social @asms.org @harvardcellbio.bsky.social

#ASMS2025 is fast approaching, and I'm looking forward to catching up with friends and seeing a lot of great mass spectrometry research. If you’re there, check out my Tuesday talk (TOE 3:10 PM) to learn how BioPlex is enhancing drug discovery!

Harvard's president tells NPR he finds Trump's recent measures "perplexing."

"Why cut off research funding? Sure, it hurts Harvard, but it hurts the country," he said, adding that those dollars are awarded to efforts deemed "high-priority work" by the government. https://n.pr/43hPDhX

EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...

NIH's work saves lives—& Trump is gutting it.

Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries.

We ALL need to speak up to save it.

Multimodal cell maps as a foundation for structural and functional genomics @nature.com @edhuttlin.bsky.social
www.nature.com/articles/s41...