Dave Leigh

El Prof. Emilio M. Pérez es nombrado nuevo director del Instituto IMDEA Nanociencia, continuando nuestra misión de impulsar la investigación de excelencia en nanociencia y nanotecnología.

+info nanociencia.imdea.org/es/imdea-nan...

Our latest collaborative preprint from the group and @kilbinger-group.bsky.social is out - tinyurl.com/3bbrfyhw - we've been looking at creating stably folded, helical, and polyfluorinated transmembrane channels with rates of water transport exceeding Aquaporins. Great to see the manuscript up!

Here is a full text, view only, version of the paper: shorturl.at/7ISdf

Chiral catalysis-driven rotary molecular motors - Nature Chemistry The structural anisotropy necessary for the powered directional rotation of chemically fuelled molecular motors had previously been provided by chiral fuels or enzymes. Now it has been shown that asym...

Out today in @natchem.nature.com 😃 Huakui, @stefanborsley.bsky.social @benjaminoacid.bsky.social & co illustrate why catalysis-driven motors (like motor proteins) can't use designs based on light-driven motors or molecules-that-rotate-through-multi-reaction-sequences www.nature.com/articles/s41...

Wow, that’s a lot of brilliance in one photo! 😍 Are you sure you’re allowed to all be in the same place at the same time? Merry Christmas all! 🎄🎅#MASC2025 #RSC_MASC

UK to rejoin EU’s Erasmus student exchange programme Exclusive: British students will be able to participate in EU-wide scheme from January 2027, sources say

Brilliant news!😃🇪🇺 www.theguardian.com/world/2025/d...

Unfortunate 😳

Reductive radical chain initiation through the thermal generation of carbon dioxide radical anion - Nature Synthesis Radical chain initiation strategies are fundamental to the synthesis of small molecule drugs and macromolecular materials. Here a general, thermally driven and scalable method for reductive initiation...

Great to see this collaborative work out in @natureportfolio.nature.com , led by Michael James @manchester.ac.uk and James Douglas @astra-zeneca.bsky.social

Congrats to Ethan Lim and everyone involved!

www.nature.com/articles/s44...

#Chemistry #Collaboration #AcademicIndustry #compchem

Acceleration of [2]Catenane Formation by One of its Rings This highlight underscores the most straightforward synthesis of [2]catenanes from readily available molecular precursors: The one-pot, two-step catenane formation from a crown ether, a linear diamin...

Jean-Claude Chambron highlights the work by @profdaveleigh.bsky.social and co-workers on the synthesis of [2]catenanes from readily available molecular precursors via a metal-free active template approach. Have a look at the article at onlinelibrary.wiley.com/doi/10.1002/... #AngewandteChemieNovit

Drs Clare Megarity & Jack Rowbotham😃

Fantastic talk from @marklautens.bsky.social, our 2025 T Y Shen Lecturer! Ably supported by…

A trip “home” - back to the area my family emigrated from in 1951!

They left Oldham after WWII, when jobs were in short supply for unskilled workers.

I return a few years later to give the TY Shen Lecture University of Manchester with my kind host @profdaveleigh.bsky.social

‼️ Today, we have the great pleasure to host David Leigh @profdaveleigh.bsky.social in Rennes. He is currently giving an incredible talk about "Giving chemistry direction". 👍

@iscr-rennes.bsky.social

Multiple Template Site Nitrogen Atom Deletions from Rotaxanes, Catenanes, and a Molecular Knot We report the deletion of nitrogen atoms from multiple template sites in rotaxanes, catenanes, and a molecular knot. Nitrogen extrusion from secondary amines in the backbone of the interlocked structures is achieved using O-diphenylphosphinylhydroxylamine (DPPH), forming carbon–carbon bonds while largely maintaining the integrity of the original mechanical bonding. We find that DPPH gives improved yields (up to 51%) for nitrogen atom deletions from template sites in rotaxanes compared to an anomeric amide nitrogen-deletion reagent and overcomes a major substrate limitation in that, using DPPH, only one of the substituents of the secondary amine in the rotaxane axle needs to be radical-stabilizing. Multiple template site nitrogen atom deletions were accomplished from a range of mechanically interlocked architectures, despite the potential for dethreading, unlinking, and/or strand uncrossing during each successive deletion event. Highlights include the deletion of two template sites from a doubly threaded [3]rotaxane (37% yield) and [3]catenane (45%), quadruple N-deletion of amines from both rings of a [2]catenane (33%), and six N-deletions from the six amine groups in a molecular trefoil knot (7%). The combination of skeletal editing with template synthesis provides a general strategy for synthesis that significantly increases the structural diversity of interlocked molecules that are potentially accessible.

...Yet here in @jacs.acspublications.org Daniel, Qi, Jess & co show they can delete multiple template sites from rotaxanes, catenanes and a molecular knot, severing the strands multiple times, and still end up with mechanically interlocked molecules. Amazing!🤯 pubs.acs.org/doi/10.1021/...

Chemistry involves such large and small numbers that it’s often hard to take in just how fast some processes occur. Dethreading a ring off the open end of a chain when there are no binding interactions present, or passing the end of one strand past another, are incredibly fast processes...

In Macclesfield?😲

An information ratchet improves selectivity in molecular recognition under non-equilibrium conditions - Nature Nanotechnology An abiotic information ratchet mechanism increases selectivity for the correct DNA duplex from 2:1 at equilibrium to 6:1 under energy-dissipating conditions.

Information ratchets drive many molecular motors, but we can also use them for other nonequilibrium processes like performing error correction in a molecular recognition process to increase selectivity. Published today in @natnano.nature.com
www.nature.com/articles/s41...

In Situ Quantification of Directional Rotation by a Catalysis-Driven Azaindole-N-Oxide–Phenoic Acid Molecular Motor We report the in situ quantification of directional rotation of a new type of catalysis-driven rotary motor featuring a phenyl carboxylic acid rotor attached to a 7-azaindole-N-oxide stator through a biaryl C–N bond. Continuous directional rotation of the rotor about the stator is driven by the achiral motor’s rotary catalysis of carbodiimide hydration in the presence of a chiral pyrrolidinylpyridine-N-oxide. The catalytic cycle features an intermediate O-acyl-azaindole-N-oxide ester tether formed between the carboxylic acid of the rotor and the N-oxide of the stator. Face-selective cleavage of the tether by the chiral pyrrolidinylpyridine-N-oxide additive generates relatively long-lived diastereomeric pyridine-N-oxide esters of the phenyl carboxylic acid. These are hydrolyzed during the catalytic cycle to reform the carboxylic acid resting state of the motor, completing net directional 360° rotation. In contrast to previous catalysis-driven motor-molecules, the motor’s directionality could be determined directly from the transient concentrations of the diastereomeric intermediates formed during rotary catalysis. This avoids reliance on restricted rotation models to assess motor directionality and provides direct access to other key performance indicators such as motor speed and catalytic, coupling and fuel efficiency. The in situ-determined directionality of the motor was found to be in excellent agreement with the directionality determined from a restricted rotation model, supporting both the efficacy of the new approach and the validity of using appropriately designed restricted rotation models. The results establish a straightforward method for the in situ quantification of various aspects of motor behavior, aiding the design and optimization of artificial molecular motors.

Can you work out how fast a molecular motor rotates from in situ measurments? Turns out that yes, you can, as we show today in @jacs.acspublications.org
pubs.acs.org/doi/10.1021/...
@profdaveleigh.bsky.social @stefanborsley.bsky.social

'Ullo @jacs.acspublications.org, Hua-Kui, Axel, @benjaminoacid.bsky.social & @stefanborsley.bsky.social have gotta new motor! doi.org/10.1021/jacs...

Delighted to follow @mvdelius.bsky.social into the 1st issue of @angewandtechemie.bsky.social Novit! Congrats to Jiankang, Enzo, Patrick, Axel, Andrei & Dan on the spontaneous assembly of catenanes lacking strong recognition sites🔗😃 onlinelibrary.wiley.com/doi/full/10....

Lovely evening at the fabulous @nationalgalleries.bsky.social in Edinburgh for the unveiling of portraits of recent Scottish chemistry Nobel laureates Sir Fraser Stoddart, Richard Henderson & Sir Dave MacMillan😃. Sir Fraser captured looking like he wanted to get back to work!😆

I did not know that, Peggy 😃 The sales person at Harrods told us that the products have a very loyal customer base, lots of repeat business.

Walking through Harrods unexpectedly spotted a familiar X-ray structure!😍Received free sample for my skincare regime😎

Sadly it was only British cheeses, but a very nice Isle of Mull cheddar do that was fine 🧀

Probably shooting up in the toilets 🤷‍♂️

Novak up a break but down a set 😱 The Queen looking on….

Jam on cream obvs 😋

Wombling free!🎾