Moritz Treeck

🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥
www.biorxiv.org/content/10.6...

Excited to release the Herculean efforts of @scottchisholm.bsky.social &Co. defining the subcellular #hyperLOPIT spatial proteome of #Plasmodium schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified.
www.biorxiv.org/content/10.1...

Congrats Alex!

You are always welcome:) Next time we'll ensure there is beach weather!

David Jones PhD manuscript on how mild heat stress (experienced during fever episodes in most malaria infections)changes the cytoadhesion behavior of parasite infected red blood cells is now online and reviewed in eLife.

elifesciences.org/reviewed-pre...

Congrats Matt! Very well deserved.

The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound - Nature Microbiology FIKK effector kinases underwent rapid evolutionary expansion and are a druggable target in Plasmodium falciparum.

Better late than never, but I am thrilled to share our newest research from the Treeck lab!!! www.nature.com/articles/s41...

thanks to @stephanienofal.bsky.social, @hbelda.bsky.social, Gwendolin Fuchs, Goska Broncel, @danaguano.bsky.social

Thanks for funding from the
@erc.europa.eu
@crick.ac.uk
@wellcometrust.bsky.social
and the FCT

What happens when the parasite that causes malaria in humans experiences fever-induced heat stress in its host red blood cell?

Check out David Jones' PhD work now on BioRxiv

www.biorxiv.org/content/10.1...

Excellent and thought-provoking. A highly recommended read

Really cool work! Congrats all!

👏!

GIMM PhD Programme now open. 17 PhD positions and a few more to come.

gimm.pt/course/phd-p...

This is SO important!

👏

@christianlandry.bsky.social, @ljwalport.bsky.social, @ant1-claessens.bsky.social, @stephanienofal.bsky.social, and all our Bluesky-less collaborators from the lab, @crick.ac.uk and @glaxosmithkline.bsky.social and @erc.europa.eu, @crick.ac.uk and @gimmfoundation.bsky.social for funding and hosting

Many thanks to many collaborators, without whom this almost 10 year effort (the structure was hard to crack!) would have been impossible to achieve. 3/n

For the aficidinados of evolution of kinases in general, those interested in this kinase family in field isolates and their role in host-pathogen interaction, their unusual structure, to finding a starting point for collective inhibiton: there is lot's to read in the paper.

2/n

Huge congratulations to @hbelda.bsky.social and David Bradley for their publication on the extraordinarily interesting FIKK kinase family (I am biased) of the malaria causing parasite Plasmodium falciparum. 1/n

Dislike!
But congratulations of course!!

Great work!

Congrats- great work!

Congrats Eva - great news!

The more we learn about Toxoplasma virulence factors, the more interesting questions pop up! This is one of ~250 proteins the parasites secretes into the host cell, or in the vacuole the parasite lives in. Much more to discover!

Happy Easter all!

2/2

A common virulence factor that protects Toxoplasma (and probably related parasites) from clearance in genetically diverse murine hosts. A heroic CRISPR screening effort from @fratorelli.bsky.social with some help from colleagues. Thanks to anonymous reviewers for some good suggestions.
1/2

Open call for 3 Group Leader Positions at the newly formed GIMM in Lisbon! Strong core facilites, Science across many disciplines + Sunshine, Beaches and the Atlantic.

Link to call here

gimm.pt/jobs/open-ca...

m6A modifications in sexual differentiation of the malaria causing parasite Plasmodium falciparum. Bravo team Baumgarten and colleagues!

PhD Summer School on Host-Microbe Symbioses 2025 Symbnet PhD Summer School on Host-Microbe Symbioses Gulbenkian Institute for Molecular Medicine (GIMM) & Católica Biomedical Research Centre (CBR) July 06...

Symbnet PhD Summer School on Host-Microbe Symbioses - Oeiras Portugal. Students from all over the world are eligible, we sponsor selected students. Please Repost!
gimm.idloom.events/phd-summer-s...

I am beyond excited to share that you can now apply to observe a @wellcometrust.bsky.social #DiscoveryResearch shortlisting Committee! If you plan to apply to us in the next 2 years, apply to be an Observer now to better understand what happens once you click submit! wellcome.org/grant-fundin...

Host-Microbe Symbioses- Our favorite summer school is back! Help us spread the word!