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Gc Rox

@gcrox.bsky.social

Hank Seifert is a Professor at Northwestern Medical School in Chicago. I'm interested in everything, particularly bacteria, but our group studies the Neisseria gonorrhoeae pilus—antigenic variation and functions.

330 Followers  |  745 Following  |  32 Posts  |  Joined: 13.11.2024  |  1.7264

Latest posts by gcrox.bsky.social on Bluesky

Please contact Congress ASAP to raise awareness of this accounting plan.

28.07.2025 18:35 — 👍 0    🔁 0    💬 0    📌 0

Cools story about bacterial crosstalk influencing disease relevant traits! 🧪

26.07.2025 12:05 — 👍 12    🔁 5    💬 0    📌 0
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Northwestern Micro representing at the 2025GRC MAST conference in beautiful Newport. Great science, collegial people but there’s a cloud hanging over us all. ☁️

24.07.2025 19:39 — 👍 16    🔁 2    💬 0    📌 1
graphical abstract of the article the extended mobility of plasmids

graphical abstract of the article the extended mobility of plasmids

Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...

23.07.2025 07:35 — 👍 184    🔁 92    💬 4    📌 9
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Infection and Immunity Journal Homepage Infection and Immunity Journal helps microbiologists, immunologists, epidemiologists, pathologists, and clinicians develop novel strategies to prevent or treat infectious diseases.

Many exciting initiatives led by EIC
@abaumler.bsky.social on including New Voices in Microbiology and special topics issues - check it out! journals.asm.org/journal/iai

23.07.2025 13:07 — 👍 1    🔁 2    💬 0    📌 0

New preprint! We characterise the small, regulatory RNA Arp which controls DNA uptake and twitching motilty in A. baumannii. Led by our Dr Fergal Hamrock @hamrockfergal.bsky.social and in collaboration with @westermannlab.bsky.social and Mike Gebhardt's lab!

21.07.2025 14:56 — 👍 2    🔁 6    💬 0    📌 1
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Expansion of tetM-Carrying Neisseria gonorrhoeae in the United States, 2018–2024 | NEJM During 2018–2024, the percentage of N. gonorrhoeae isolates carrying tetM, which confers tetracycline resistance, increased from less than 10% to more than 30% across the United States.

New @nejm.org report shows a rapid rise in tetM-carrying Neisseria gonorrhoeae strains in the U.S. jumping from <10% in 2020 to >30% by early 2024.
Why? Likely linked to our increased use of doxycycline both for STI treatment and DoxyPEP.
#MedSky #IDSky
www.nejm.org/doi/full/10....

11.07.2025 12:24 — 👍 48    🔁 24    💬 4    📌 2
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Goodbye and good luck in graduate school, Kabita Kunwar!

11.07.2025 17:51 — 👍 3    🔁 0    💬 0    📌 0
David Holden's breakthrough or suing barcoding and transposon mutagenesis to identify negative selection mutants.

David Holden's breakthrough or suing barcoding and transposon mutagenesis to identify negative selection mutants.

science.sciencemag.org/content/269/...

08.07.2025 19:44 — 👍 0    🔁 0    💬 0    📌 1

🍂 👿 Brown University has not Received NIH Grant Payments Since April
🧪
"Department of Health and Human Services (HHS) also told NIH to not communicate with the schools about 'whether or why the funds are frozen' "
fiercebiotech.com/

01.07.2025 15:55 — 👍 1    🔁 5    💬 0    📌 0
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White House Eyes Rarely Used Power to Override Congress on Spending

Important story about OMB's plans with regard to appropriated funds. This is a big deal, both practically and constitutionally.

[Gift article]

www.nytimes.com/2025/06/17/u...

19.06.2025 14:58 — 👍 86    🔁 52    💬 10    📌 15
Two line graphs show NIH Outlays for Grants at Brown University. The left graph, "Outlay per month (USD)," shows monthly outlays from October (P01-P02) to June (P09) for fiscal years 2022, 2023, 2024, and 2025. The 2025 line (black) shows outlays around $15,000,000 from October 2024 to March 2025, then drops sharply to $0 in April 2025 and remains at $0 for May and June. Lines for previous fiscal years remain above $10,000,000 throughout the period. The right graph, "Percent of grants without an outlay," shows the percentage of grants without monthly outlays over the same period. The 2025 line (black) shows percentages below 10% until March 2025, then spikes to 100% in April 2025 and remains at 100% for May and June. Lines for previous fiscal years remain below 20%.

Two line graphs show NIH Outlays for Grants at Brown University. The left graph, "Outlay per month (USD)," shows monthly outlays from October (P01-P02) to June (P09) for fiscal years 2022, 2023, 2024, and 2025. The 2025 line (black) shows outlays around $15,000,000 from October 2024 to March 2025, then drops sharply to $0 in April 2025 and remains at $0 for May and June. Lines for previous fiscal years remain above $10,000,000 throughout the period. The right graph, "Percent of grants without an outlay," shows the percentage of grants without monthly outlays over the same period. The 2025 line (black) shows percentages below 10% until March 2025, then spikes to 100% in April 2025 and remains at 100% for May and June. Lines for previous fiscal years remain below 20%.

Two line graphs show NIH Outlays for Grants at Columbia University. The left graph, "Outlay per month (USD)," shows monthly outlays from October (P01-P02) to June (P09) for fiscal years 2022, 2023, 2024, and 2025. The 2025 line (black) shows outlays between $40,000,000 and $60,000,000 from October 2024 to March 2025, then drops sharply to approximately $20,000,000 in April 2025 and to $0 in May and June. Lines for previous fiscal years fluctuate but remain generally above $25,000,000. The right graph, "Percent of grants without an outlay," shows the percentage of grants without monthly outlays over the same period. The 2025 line (black) shows percentages below 20% until March 2025, then spikes to 100% in April 2025 and remains at 100% for May and June. Lines for previous fiscal years remain mostly below 20%.

Two line graphs show NIH Outlays for Grants at Columbia University. The left graph, "Outlay per month (USD)," shows monthly outlays from October (P01-P02) to June (P09) for fiscal years 2022, 2023, 2024, and 2025. The 2025 line (black) shows outlays between $40,000,000 and $60,000,000 from October 2024 to March 2025, then drops sharply to approximately $20,000,000 in April 2025 and to $0 in May and June. Lines for previous fiscal years fluctuate but remain generally above $25,000,000. The right graph, "Percent of grants without an outlay," shows the percentage of grants without monthly outlays over the same period. The 2025 line (black) shows percentages below 20% until March 2025, then spikes to 100% in April 2025 and remains at 100% for May and June. Lines for previous fiscal years remain mostly below 20%.

Two line graphs show NIH Outlays for Grants at Cornell University. The left graph, "Outlay per month (USD)," shows monthly outlays from October (P01-P02) to June (P09) for fiscal years 2022, 2023, 2024, and 2025. The 2025 line (black) shows outlays between $10,000,000 and $20,000,000 from October 2024 to March 2025, then drops to $0 in April 2025 and remains at $0 for May and June. Lines for previous fiscal years show some variability but generally stay above $0, with some dips. The right graph, "Percent of grants without an outlay," shows the percentage of grants without monthly outlays over the same period. The 2025 line (black) shows percentages below 20% until March 2025, then spikes to 100% in April 2025 and remains at 100% for May and June. Lines for previous fiscal years show more variability than Harvard and Northwestern, with some spikes, as well, but returning to normal levels after.

Two line graphs show NIH Outlays for Grants at Cornell University. The left graph, "Outlay per month (USD)," shows monthly outlays from October (P01-P02) to June (P09) for fiscal years 2022, 2023, 2024, and 2025. The 2025 line (black) shows outlays between $10,000,000 and $20,000,000 from October 2024 to March 2025, then drops to $0 in April 2025 and remains at $0 for May and June. Lines for previous fiscal years show some variability but generally stay above $0, with some dips. The right graph, "Percent of grants without an outlay," shows the percentage of grants without monthly outlays over the same period. The 2025 line (black) shows percentages below 20% until March 2025, then spikes to 100% in April 2025 and remains at 100% for May and June. Lines for previous fiscal years show more variability than Harvard and Northwestern, with some spikes, as well, but returning to normal levels after.

Two line graphs show NIH Outlays for Grants at Northwestern University. The left graph, "Outlay per month (USD)," shows monthly outlays from October (P01-P02) to June (P09) for fiscal years 2022, 2023, 2024, and 2025. The 2025 line (black) shows outlays around $30,000,000 from October 2024 to March 2025, then drops sharply to $0 in April 2025 and remains at $0 for May and June. Lines for previous fiscal years remain above $25,000,000 throughout the period. The right graph, "Percent of grants without an outlay," shows the percentage of grants without monthly outlays over the same period. The 2025 line (black) shows percentages below 15% until March 2025, then spikes to 100% in April 2025 and remains at 100% for May and June. Lines for previous fiscal years remain below 20%.

Two line graphs show NIH Outlays for Grants at Northwestern University. The left graph, "Outlay per month (USD)," shows monthly outlays from October (P01-P02) to June (P09) for fiscal years 2022, 2023, 2024, and 2025. The 2025 line (black) shows outlays around $30,000,000 from October 2024 to March 2025, then drops sharply to $0 in April 2025 and remains at $0 for May and June. Lines for previous fiscal years remain above $25,000,000 throughout the period. The right graph, "Percent of grants without an outlay," shows the percentage of grants without monthly outlays over the same period. The 2025 line (black) shows percentages below 15% until March 2025, then spikes to 100% in April 2025 and remains at 100% for May and June. Lines for previous fiscal years remain below 20%.

NEW at grant-watch.us: Emma Mairson and Marian Jarlenski report on funding freezes at Brown, Columbia, Cornell, and Northwestern, that have received zero payments for #NIH grants since the start of April: grant-watch.us/posts/trends...

08.06.2025 13:33 — 👍 23    🔁 20    💬 1    📌 2

Where is here?

09.06.2025 13:27 — 👍 0    🔁 0    💬 1    📌 0

This is more than just lost grant dollars...this is patients in experimental treatments for incurable cancers having to stop their course of treatment.

It's patients with medical devices going unmonitored.

It's entire lines of groundbreaking science coming to a hard stop.

#DownWithDOGE

09.06.2025 11:23 — 👍 145    🔁 46    💬 2    📌 1

👏🏽👏🏽👏🏽🇨🇦🇨🇦🇨🇦

05.06.2025 16:45 — 👍 14    🔁 10    💬 1    📌 0
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Medical Research Funding — Unbreaking How the administration is breaking the government, and what that means for all of us.

Comprehensive reporting of issues with US science funding. unbreaking.org/issues/medic...

31.05.2025 12:35 — 👍 0    🔁 0    💬 0    📌 0

#AcademicSky #EduSky

28.05.2025 00:33 — 👍 3    🔁 3    💬 2    📌 0

Neither was my son

24.05.2025 15:43 — 👍 1    🔁 0    💬 0    📌 0

Because Congress (the legislative body) appropriated the $ to NIH and after rigorous reviews each project was funded. Do you pay your bills to corporations who have billions?

24.05.2025 15:43 — 👍 0    🔁 0    💬 1    📌 0

I didn't know! Thanks for posting.

23.05.2025 19:01 — 👍 2    🔁 0    💬 0    📌 0

All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!

23.05.2025 17:56 — 👍 2286    🔁 1340    💬 35    📌 32
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Northwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025

18.05.2025 22:44 — 👍 1484    🔁 616    💬 20    📌 65
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CRISPRi-mediated repression of three cI repressors induces the expression of three related Neisseria gonorrhoeae bacteriophages | Journal of Bacteriology Bacteriophage, or phage, are bacteria-infecting viruses and are the most abundant natural entities in the world. Here, we report that Neisseria gonorrhoeae’s three most complete double-stranded DNA pr...

Nice final pub from Dr. Wendy Geslewitz to finish her dissertation work.

CRISPRi-mediated repression of three cI repressors induces the expression of three related Neisseria gonorrhoeae bacteriophages | Journal of Bacteriology journals.asm.org/eprint/6C2IM...

19.05.2025 19:28 — 👍 7    🔁 0    💬 0    📌 0
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National Academy of Sciences Elects Members and International Members - NAS WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 30 international members in recognition of their distinguished and continuing achievements in original res...

Congratulations to Eric Skaar and all of the new National Academy Members.
www.nasonline.org/news/2025-na...

30.04.2025 16:29 — 👍 8    🔁 2    💬 0    📌 0

Check out the back to back cool papers from @jutraslab.bsky.social #MicroSky www.science.org/doi/10.1126/...

24.04.2025 14:13 — 👍 4    🔁 2    💬 0    📌 1
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Vibrio MARTX toxin binding of biantennary N-glycans at host cell surfaces The large pore-forming toxin MARTX with broad tissue tropism binds the essential unit of N-glycans on eukaryotic cell membranes.

Taking a break from the news in Bsky. Happy to share amazing study by student Jiexi Chen on Vibrio vulnificus MARTX toxin engagement of N-glycans and receptor L1CAM. First study on this toxin binding to cell surfaces. #vibrio #microsky #toxins www.science.org/doi/10.1126/...

11.04.2025 12:12 — 👍 12    🔁 3    💬 0    📌 0

That can’t be correct, would mean that I am …. Never mind.

05.04.2025 11:29 — 👍 3    🔁 0    💬 0    📌 0
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Congratulations to Wendy Geslewitz for defending her PhD work.

27.03.2025 15:49 — 👍 5    🔁 0    💬 0    📌 0

In a new National Postdoctoral Association report, 43% of postdocs said Trump administration policies have threatened their positions, while more than one-third…

14.03.2025 02:18 — 👍 0    🔁 0    💬 0    📌 0
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Stand Up for Science Rally Sees Mix of Science, Politics and Anxiety Thousands of protesters gathered in Washington for Stand Up for Science, a rally in response to President Trump’s federal-funding and job cuts.

www.nytimes.com/2025/03/08/s...
This article is not even on the first page - let’s try to give the @standupforscience.bsky.social rallies some visibility!

08.03.2025 18:22 — 👍 24    🔁 10    💬 2    📌 1

@gcrox is following 20 prominent accounts