Danilo Buonsenso

A Pathogenic Monocyte Signature in Long COVID: What It Means for Buonsenso and the Kids Long COVID has puzzled scientists, clinicians, and families alike for years — especially when children and adolescents continue to struggle with fatigue, shortness of breath, and other persistent symp...

A Pathogenic Monocyte Signature in Long COVID: What It Means for Buonsenso and the Kids

danilobuonsenso.substack.com/p/a-pathogen...

Long COVID is here to stay—even in children Post-acute sequelae of SARS-CoV-2 infection (PASC, also known as long COVID) are complex, multisystem, long-lasting complications of SARS-CoV-2 infection that profoundly impact the daily life of those...

"These findings reinforce an urgent message that children and adolescents can develop #LongCovid not only after an initial infection, but also after reinfection. The public health implications are substantial." @buonsenso.bsky.social

www.thelancet.com/journals/lan...

#LongCovidKids #Children

Long COVID is here to stay—even in children Post-acute sequelae of SARS-CoV-2 infection (PASC, also known as long COVID) are complex, multisystem, long-lasting complications of SARS-CoV-2 infection that profoundly impact the daily life of those...

Long COVID is here to stay—even in children 😢
@buonsenso.bsky.social

These findings reinforce an urgent message that children and adolescents can develop long COVID not only after an initial infection, but also after reinfection. The public health implications are substantial.
Before this study,

Plasmapheresis, apheresis, and why people with Long Covid or ME/CFS talk about them as we are implementing a protocol for plasmapheresis in patients with Long Covid and ME/CFS, I wanted to summarize with you what it is and why we are thinking about that.

Plasmapheresis, apheresis, and why people with Long Covid or ME/CFS talk about them

danilobuonsenso.substack.com/p/plasmapher...

Long COVID: When the Fire Inside Never Turns Off — A Personal Reflection Every parent wants their child to be healthy and whole.

Long COVID: When the Fire Inside Never Turns Off — A Personal Reflection

danilobuonsenso.substack.com/p/long-covid...

after years of illness and gaslighting, this kid with #LongCovid is leaving again❤️
grateful for this mum’s email.

Why IVIG and immunemodulation work most time is written since two years in my book tinyurl.com/4tsvhwat

and blog substack.com/@mecfslongco...

where?

Abnormal Energy Metabolism and Immune Signatures in ME/CFS: What the Latest Paper Means for Kids and Families Chronic fatigue syndrome (ME/CFS) remains one of the most puzzling, debilitating disorders in medicine — especially when it affects children and adolescents.

Energy Metabolism and Immune Signatures in ME/CFS: What the Latest Paper Means for Kids and Families

danilobuonsenso.substack.com/p/abnormal-e...

Long COVID, Immune Dysregulation & What It Means for Kids — New Insights and Future Therapies Long COVID isn’t just a collection of lingering symptoms — it may reflect deep changes in the immune system that can persist for years.

Long COVID, Immune Dysregulation & What It Means for Kids — New Insights and Future Therapies

danilobuonsenso.substack.com/p/long-covid...

When I started the #longcovid in kids journey we were literally alone.
Now, we arrived to speak about long covid in children in @TheLancetInfDis Podcast!❤️

MY LONG COVID JOURNEY, WHAT I DO AND WHY IN MY BOOK: tinyurl.com/4tsvhwat

🔊 Spotify: bit.ly/4p7jnpy

You Are Not Alone – Let’s Connect Families, Young People and Communities Living with Long Covid and ME/CFS When a child, teenager, or young adult develops Long Covid or ME/CFS, the world can suddenly become very small.

You Are Not Alone – Let’s Connect Families, Young People and Communities Living with Long Covid and ME/CFS

danilobuonsenso.substack.com/p/you-are-no...

a new major study on Nature immunology further reinforces the overwhelming evidence of chronic immune activation in #longcovid, perfectly justifying off label use of immune modulators (eg IVIG) in the most severe cases that cannot access trials.
Saying since a few years in my book

lnkd.in/dPHkH3re

So the Pediatric Infectious Diseases games are ready to go in 2d!
Impressive amount of different european countries participating this year!

I know, in these cases it’s not worth it

When Patients Ask for a Cure: A Doctor’s Honest Reflection on Long Covid and ME/CFS In the past months, my inbox (and whatsapp!) has filled with messages from patients and families living with Long Covid or ME/CFS.

When Patients Ask for a Cure: A Doctor’s Honest Reflection on Long Covid and ME/CFS

danilobuonsenso.substack.com/p/when-patie...

Oxaloacetate, long COVID and ME/CFS: what the new trial shows — and a pragmatic (non-prescriptive) scheme for clinicians Fatigue and cognitive fog remain among the most disabling complaints for people with long COVID and with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Oxaloacetate, long COVID and ME/CFS: what the new trial shows — and a pragmatic (non-prescriptive) scheme for clinicians

danilobuonsenso.substack.com/p/oxaloaceta...

let us know

with the only and one!!

Low-Dose Rapamycin for ME/CFS and Long COVID: New Clinical Data, Promising Hints, and Ongoing Caution Over the past months, I have written several posts exploring the potential role of low-dose rapamycin in Long COVID and ME/CFS (Part 1, Part 2, Part 3).

Low-Dose Rapamycin for ME/CFS and Long COVID: New Clinical Data, Promising Hints, and Ongoing Caution

danilobuonsenso.substack.com/p/low-dose-r...

What’s new in the Long COVID / ME/CFS endothelial story — and what that means for treatment You may remember that in earlier posts we discussed how both Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) appear to share a key feature: endothelial inflammation/dysfunct...

What’s new in the Long COVID / ME/CFS endothelial story — and what that means for treatment

danilobuonsenso.substack.com/p/whats-new-...

you’ll read several success papers about #nirsevimab and #RSV but to make it a successful and long term sustainable interventions you need to read also of out chorus provocative voices, like this one !

rdcu.be/ePXTa

Long COVID and the AMPA Pathway: New Clues from Brain Imaging Over the past few years, Long COVID has become one of the most puzzling and impactful conditions in post-viral medicine — especially for the many children and adults who continue to experience “brain ...

Long COVID and the AMPA Pathway: New Clues from Brain Imaging

danilobuonsenso.substack.com/p/long-covid...

Conversations on IVIG and Monoclonals A recording from MD, PhD's live video

Conversations on IVIG and Monoclonals in #LongCovid #MECFS

danilobuonsenso.substack.com/p/conversati...

The second-order effects that the COVID-19 pandemic has had on pediatric populations SARS-CoV-2 can have long-term health consequences that persist beyond acute infection. While this is evident in adults and the elderly, the impact on children and adolescents remains under recogniz...

new on covid impact on kids

www.tandfonline.com/eprint/ZY2VI...

retweeting allows direct engagement

When There Are No Treatments: Why Off-Label Drugs Should Be on the Table for Long Covid and ME/CFS What Does “Off-Label” Really Mean?

The latest from @buonsenso.bsky.social rings so true:

Yet when patients and families ask for treatments, the answer is almost always: “There are no approved options.”

open.substack.com/pub/danilobu...

#PedSky
#LongCovidKids
#pwLC
#pwME

Paediatric invasive group A streptococcal infections and associations with viral infections in 15 European countries after lifting non-pharmaceutical interventions against SARS-CoV-2: an interrupted t... After lifting non-pharmaceutical interventions (NPIs) against the transmission of SARS-CoV-2, various countries experienced an increase in invasive Gr…

glad our team contributed to another very important study on iGAS.
PEGASUS network

www.sciencedirect.com/science/arti...

“We Can’t Do This Alone”: A Doctor’s Plea for Support in Caring for Long COVID and ME/CFS Patients As a pediatrician and infectious disease specialist, my days are full.

“We Can’t Do This Alone”: A Doctor’s Plea for Support in Caring for Long COVID and ME/CFS Patients

danilobuonsenso.substack.com/p/we-cant-do...

again viruses and dementia.
those of you negating this slow science progression and patients prevention options.

all started w #LongCovid revolution. years ago I said LC is clearly giving this indication and now science is confirming

all in my book: tinyurl.com/4tsvhwat

Working (and Keeping Your Salary) When Long COVID or ME/CFS Makes Full-Time Work Impossible 1.

Working (and Keeping Your Salary) When Long COVID or ME/CFS Makes Full-Time Work Impossible

danilobuonsenso.substack.com/p/working-an...