Douaa Moussalem

Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!

Congratulations Charlène.
I am so happy for you and you deserve it 👏

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds t...

#Pseudouridine #RNA avoids immune detection through impaired endolysosomal processing and TLR engagement: Cell www.cell.com/cell/fulltex...

Our editors write:

- "RNA modification: A new m6A reader complex" rdcu.be/d6uG1

A highlight of this paper in @embojournal.bsky.social :
"ALBA proteins facilitate cytoplasmic YTHDF-mediated reading of m6A in Arabidopsis"
www.embopress.org/doi/full/10....

Serpents and follicle cells: a phagocytic partnership Phagocytosis is important for eliminating pathogens and dying cells and recycling cellular components. There are ‘professional phagocytes’, such as macrophages, neutrophils and dendritic cells, and ‘n...

journals.biologists.com/dev/article/...

What other mysterious functions are also played by this factor Srp to ensure fertility? ⚕️

Recently, in 2025, it got published by Dr. Jianjun Sun that Srp promotes phagocytic capacity of follicle cells during fly oogenesis. Srp is required in these cells to allow complete clearance of germline debris. A work published in the journal @dev-journal.bsky.social

In my PhD paper published in Front. Cell Dev. in 2022, i show that GATA factor Serpent (Srp) is required for fly fertility, as eggs laid by females mutant for srp are devoid of structures generated by ovarian follicle cells such as micropyle and chorion.
Recently, in 2025, it got published by

tRNA modifications tune m6A-dependent mRNA decay tRNA modifications functionally interact with m6A to regulate mRNA decay.

Cool! #m6A #tRNA #mRNADecay #RNA
tRNA modifications tune m6A-dependent mRNA decay: Cell www.cell.com/cell/fulltex...

Frontiers | Two Isoforms of serpent Containing Either One or Two GATA Zinc Fingers Provide Functional Diversity During Drosophila Development GATA transcription factors play crucial roles in various developmental processes in organisms ranging from flies to humans. In mammals, GATA factors are char...

www.frontiersin.org/journals/cel...

Thesis_work Thesis_publication 2022