Karolina Socha

Huge team effort 🚀 Congrats to all co-authors in @intlbrainlab.bsky.social for making this project and dataset possible!

From 621,733 neurons recorded with 699 Neuropixels probes across 139 mice in 12 labs, we show that task signals—visual, choice, movement, prior—are distributed widely across the brain.
I hope these results inspire future projects. The data are public!

Thrilled to share that both papers from my postdoc at @ucl.ac.uk at @carandinilab.net, as part of the International Brain Lab collaboration, are now out in @nature.com 🎉
🧠 Brain-wide neural activity during complex behavior: doi.org/10.1038/s415...
🧠 representations of prior:
doi.org/10.1038/s415...

Two flagship papers from the International Brain Laboratory, now out in ‪@Nature.com‬:
🧠 Brain-wide map of neural activity during complex behaviour: doi.org/10.1038/s41586-025-09235-0
🧠 Brain-wide representations of prior information in mouse decision-making: doi.org/10.1038/s41586-025-09226-1 +

A subcortical switchboard for perseverative, exploratory and disengaged states - Nature Behavioural experiments in mice demonstrate that GABAergic (γ-aminobutyric acid-expressing), glutamatergic and serotonergic neurons in the median raphe nucleus have distinct and complementary function...

Should you stick to your goal, try something else, or give up? Your median raphe nucleus in the brainstem knows and will decide for you 😉. First foray of my lab into foraging, behavioural strategies and exploration. Amazing work from the one and only Mehran Ahmadlou: www.nature.com/articles/s41...

⏰ Last days to apply!!⏰

This hands-on course covers:
🦠 Flies/Zebrafish – Optogenetics, 2P imaging
🐭 Mice – 2P/3P imaging, Neuropixels, closed-loop behavior

📅 June 8-27, 2025 | Champalimaud, Lisbon
⏳ Apply by March 7
🔗 loom.ly/OMvqMcE

Diagram showing MRN inhibitory, excitatory, and serotonergic neurons, each linked to distinct states: perseverance, exploration and disengagement.

New SWC research identifies the median raphe nucleus (MRN) as a critical hub for flexible switching between behavioural strategies of perseverance, exploration, and disengagement.

Full story 🔀 www.sainsburywellcome.org/web/research...

🚨 We're looking for an experimentalist to join our team at UCL! 🚨 Whether you’re looking for a postdoc role or want to gain hands-on experience as a research assistant, we’d love to hear from you. If you’re excited about visual circuits, systems neuroscience & mouse behavior, please get in touch!

BAMB! Course philosophy Our goal is​ to teach advanced techniques in model-based analysis of behavior (humans and other animals) to cognitive and computational neuroscientists at PhD and early career levels...

Our Barcelona-based summer school, BAMB! (bambschool.org) just opened applications! Come join us: 15-24th July, to learn how to model behavioral data using RL, Bayesian, latent variable models, RNNs, DDMs & more! #BAMB2025

Applications are now open! 3-week courses: Comp Neuro and Deep Learning. 2-week courses: NeuroAI and Comp Tools for Climate Science.

🚨 Neuromatch Academy Course Applications are OPEN for 2025!! 🚨

Get your application in early to be a student or teaching assistant for this year’s courses!

Applications are due Sunday, March 23.

Apply & learn more: neuromatch.io/courses/

#mlsky #compneurosky #ai #climatesolutions #ScienceEdu 🧪

Paris Circuit Dynamics This two-day conference will bring together leading experts from the Paris region and abroad to discuss the dynamics and neural coding in hippocampal and cortical circuits. The program will focus on ...

Very happy to announce the "Paris Circuit Dynamics Conference 2025: Hippocampal–Cortical Circuits: From structure to computation", on 28 - 29 April 2025 at the Paris Brain Institute.

You are welcome to register and join us!

www.paris-circuits.eu

A neural implementation model of feedback-based motor learning - Nature Communications How the brain adapts our movements to new conditions remains unclear. Here, the authors show that a recurrent neural network that controls its output using error-based feedback can learn to count...

Want to hear more about how feedback can guide learning in RNNs for motor adaptation. Here is our new paper in Nat. Com. with Barbara Feulner and @juangallego.bsky.social www.nature.com/articles/s41...

Congrats Jean-Paul!!!

📣 The 11th Statistical Analysis of Neuronal Data (SAND11) workshop will be held June 11-13, 2025 in New York at the @flatironinstitute.org with generous support from @simonsfoundation.org

Submissions for talks+posters are due March 21. See our website for details 👇

sandworkshop.github.io

Mice dynamically adapt to opponents in competitive multi-player games Competing for resources in dynamic social environments is fundamental for survival, and requires continuous monitoring of both 'self' and 'others' to guide effective choices. Yet our understanding of ...

First preprint from our lab! An @jerlich.bsky.social collaboration

We developed novel frameworks to study multi-agent decisions in mice.

Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information!

www.biorxiv.org/content/10.1...

Excited to announce multiple #PhD & #Postdoc positions opening in my lab over the next three years as part of the #ERC Starting grant DIVERSE! Reposts appreciated 😊 #neuroscience #neuroskyence

It may take less than 5 years. That technology is just more complex and takes longer to produce than standard Npx probes.

Project made possible by: @wellcometrust.bsky.social, @alleninstitute.bsky.social, @hhmijanelia.bsky.social, and other funders: IMEC, the NIH BRAIN Initiative, NTNU, Johns Hopkins University, UW, and @uclbrainscience.bsky.social.

and to the Neuropixels Opto Consortium: @carandinilab.net, Barun Dutta, Tim Harris, Michael Häusser, @sonjahofer.bsky.social, @edvardmoser.bsky.social, Josh Siegle, @steinmetzneuro.bsky.social, and Karel Svoboda.

to project collaborators: Alexander Ladd, Anna Bowen, Susu Chen, Jennifer Colonell, Anjal Doshi, Bill Karsh, Michael Krumin, Pavel Kulik, Anna Li, Meghan Olsen, Zhiwen Ye, Christof Koch, Jonathan T. Ting

Huge kudos to the imec team: Pieter Neutens, Jan Putzeys, John O'Callaghan, Harrie A.C. Tilmans, and Marleen Welkenhuysen

These probes let us evoke activity in neurons near the emitter sites, enabling spatial and temporal control across different depths of the mouse cortex.

Some snippets of results: we successfully triggered activity in excitatory neurons expressing the red-shifted opsin ChRmine with both long and short light pulses. We show that the probes can be used for precise activation, identification, and manipulation of neuronal populations!

Thrilled to share our latest work exploring new avenues for combining #Neuropixels with #Optogenetics! Congratulations to co-first author Anna Lakunina, the Neuropixels Opto Consortium and collaborators! www.biorxiv.org/content/10.1...