@stijnnuiten.bsky.social
Postdoctoral researcher at the Translational Psychiatry Lab, University of Basel & UPK Basel. Interested in the role of neuromodulatory systems and arousal on perception in health and disease.
Please share: Postdoc position available in a new collaborative SNSF project with @georgkeller.bsky.social at @fmiscience.bsky.social using a cross-species approach in humans and mice to investigate the cortical circuit mechanisms underlying schizophrenia. Apply at karriere.upk.ch/Postdoctoral...
13.10.2025 07:02 — 👍 14 🔁 10 💬 1 📌 1
To celebrate the defence of my PhD, and thanks to
@ibbamsterdam.bsky.social, I will host a symposium titled "Vision as prediction: learning, action, and biases" on June 6. Program, registration and more information here: bit.ly/43reOgR
For more details, go check out the full preprint at: dx.doi.org/10.21203/rs.... (6/6)
19.05.2025 15:13 — 👍 0 🔁 1 💬 0 📌 0
Bias manipulation modulates pre-stimulus motor cortex lateralisation, reflecting a starting point bias. This task-related modulation of lateralised activity is weakest on trials with large phasic pupil-linked arousal.
Neural and computational analyses further revealed that task effects on preparatory activity over motor cortex, resembling a starting point bias, were smallest on trials with high phasic pupil-linked arousal. (5/6)
19.05.2025 15:13 — 👍 0 🔁 1 💬 1 📌 0
Tonic and phasic pupil-linked arousal distinctly related to human decision bias. Where increased tonic pupil-linked arousal is related to more liberal decision-making across experimental conditions, increased phasic pupil-linked arousal specifically relates to a minimisation of task-related bias.
Where increased tonic arousal (pupil-linked; trend for drugs) was related to more liberal ('yes') decisions independent of task, increased phasic arousal was uniquely associated with weaker task-related shifts in decision bias. Tonic & phasic arousal thus distinctly shaped decision bias. (4/6)
19.05.2025 15:13 — 👍 0 🔁 0 💬 1 📌 0
Here, we aimed to 1) uncover the neural mechanisms by which arousal governs decision bias and 2) causally test if/how tonic arousal affects bias. To do so, we combined correlational measures (pupillometry) & causal manipulations (pharmacology) of arousal with EEG and two bias-inducing tasks. (3/6)
19.05.2025 15:13 — 👍 0 🔁 0 💬 1 📌 0
Earlier work from our group revealed profound behavioral arousal effects: e.g. elevated tonic arousal improves centroparietal sensory evidence accumulation but impairs prefrontal metacognitive processes (doi.org/10.1523/ENEU...), while phasic arousal modulates bias (De Gee et al, eLife, 2017). (2/6)
19.05.2025 15:13 — 👍 0 🔁 0 💬 1 📌 0⚠️ Come see our new preprint, in which we (@degeelab.bsky.social, Jasper Zantvoord, @psterzer.bsky.social, @fahrenfort.bsky.social & @svangaal.bsky.social) show that phasic (task-evoked) and tonic (baseline) arousal distinctly shape human decision bias! (1/6)
dx.doi.org/10.21203/rs....
