FMI science

Niclosamide: CRL4AMBRA1 mediated degradation of cyclin D1 following mitochondrial membrane depolarization Targeted protein degradation has emerged as a promising approach in drug discovery, utilizing small molecules like molecular glue degraders to harness the ubiquitin-proteasome pathway for selective…

🔓Check out this #OpenAccess article by @labthoma.bsky.social and colleagues where they investigated the potential of niclosamide as a molecular glue degrader targeting the proto-oncogene cyclin D1👀🔥

pubs.rsc.org/en/content/a...

📍EPFL, @fmiscience.bsky.social 🧪

How DNA packaging controls the “genome’s guardian” Our cells tightly pack DNA into structures called nucleosomes, which protect DNA but also hide important sites. The key cancer-fighting protein p53 can still access these hidden sites, especially at n...

Our cells pack DNA into tiny bundles that hide important parts. Researchers at the FMI and EPFL found this packing affects how the cancer-fighting protein p53 works, revealing new insights into cancer. www.fmi.ch/news-events/...

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Mechanistic Cell and Developmental Biology. More details ➡️ tinyurl.com/3fbkp89c

New ERC report on Europe’s competitiveness! 🇪🇺

"It conveyed a shared message that fundamental research is not a luxury.”

ERC President Maria Leptin on the conclusions from the ERC workshop with leading figures from industry, policy and science.

Read workshop report: erc.europa.eu/news-events/...

📢 Get ready for #bc2basel 2025 for an exciting programme at the intersection of bioinformatics &AI.

🎉 We received 252 abstracts & after careful review, 42 top contributions were selected for oral & pitch presentations; +over 200 posters to discover!

👉 Explore the programme: www.bc2.ch/programme

📝 Preparing for your ERC interview? In our new ERC Classes episode learn:

🔅 What happens during the interview

🔅 How to prepare effectively

🔅Tips to stay calm & focused

▶️ Watch here 👉 bit.ly/4kDZkfZ

#EUResearch

📢 5 key updates to how you can submit funding proposals for ERC research grants this year. 👇

Want more detail, also on the evaluation process?

Watch the entire online information session 👉 bit.ly/44MnXBl

#FrontierResearch #research #grants #funding #info #HorizonEurope

Preprint by the lab of Marc Bühler with first author Josip Ahel "Remodeling Activity of ChAHP Restricts Transcription Factor Access to Chromatin" @biorxivpreprint.bsky.social
buff.ly/mTYarjo
@aheljo.bsky.social
@marcbuhler.bsky.social
@fmiscience.bsky.social

AstraZeneca, MRC Laboratory of Molecular Biology, Imperial College London, MRC Laboratory of Medical Sciences Next Generation Biophysics Symposium 2025 Wednesday 3rd September 2025 Hybrid Symposium (Zoom & MRC LMB, Cambridge) Keynote Speaker: Professor Cees Dekker Registration open

Want to hear from experts about how new and emerging technologies can be harnessed to answer complex biological questions?
Don’t mis the 2025 Next Generation Biophysics Symposium on Wednesday 3rd September!
Find out more details and register here: www3.mrc-lmb.cam.ac.uk/sites/nextgen/

Huge congratulations to Clara Nuninger for successfully defending her PhD last week! Her research used Hydra—a tiny freshwater creature famous for regrowing its body parts—to reveal how cells decide what to become 🎓🥳

"If Europe is to stay competitive and sovereign, we need a sound foundation of early-stage, cross-border collaboration at lower to mid- TRL level that fosters open-ended exploration and strong scientific communities. FP10 is the only programme where such collaborations can thrive," said Marta Agostinho, EU-LIFE Executive Director.

🚨 European research organisations including EU-LIFE call the European Commission, European Parliament and Member States for enhanced and transformed early-stage collaborative research in #FP10.

🔎 Find out more ➡️ eu-life.eu/newsroom/new...

@ec.europa.eu @europarl.europa.eu #EUcompetitiveness

🌈As part of our EDI & Pride Ambassador program, led by Laurent Gelman & Sera Weevers, we're excited to host trans advocate and author Liam Klenk for an open, informal talk on gender, identity and career development as a trans person.
🗓 July 15, 15:00 with Apéro to follow

Preprint by the lab of Marc Bühler with first author Jakob Schnabl-Baumgartner "ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment" @biorxivpreprint.bsky.social
buff.ly/hAXKoZ3
@jakobschnabl.bsky.social
@marcbuhler.bsky.social
@fmiscience.bsky.social

It has been an amazing collaboration between the Turco Lab and Computational Biology at @fmiscience.bsky.social - Thank you !

Are you new to ERC grants?

Find out about the ERC grant application and evaluation process later this week:

📆 10 July
🕒 15:00 CEST
📍 online information session

This webinar is tailored to researchers who are just starting out in their attempt to get an ERC grant.

Watch 👉 buff.ly/3kvG3yr

Thrilled to recently welcome Fiona Marshall @fionahmarshall.bsky.social to the FMI! She toured our labs, including the new FMI-Novartis Applied Tissue Models Center, and had engaging conversations with group leaders & senior admin. Thanks for visiting and fostering collaboration!

Huge congratulations to Lisa Frugoli on successfully defending her PhD this week! She developed a lab-grown model of the uterus lining to study endometrial receptivity—the brief window when the uterus is ready to accept an embryo 👏🎓

🚨The Friedrich Miescher Award call 2026 is open, honoring outstanding young biochemists in Switzerland or Swiss scientists abroad.
🔹 Under 40 (parental extensions apply)
🔹 Independent research required

📅 Deadline: Oct 31, 2025
How to nominate: www.ls2.ch/funding/awards

@fmiscience.bsky.social

📣 #Call for Project funding
Researchers can determine the nature and topic of their research projects independently. Open to all disciplines.

🗓 Submission deadline: 1 October 2025, 17:00 CEST.
➡️ buff.ly/Q1yW0oX

Earlier today @csoneson.bsky.social from @fmiscience.bsky.social gave a great keynote at this year's #gbcc2025 conference @bioconductor.bsky.social @galaxyproject.bsky.social

Proud of our Elisa Magistrati presenting at @bacell3d.bsky.social 👇🏽

It has been a long, but fascinating collaboration @fmiscience.bsky.social

New PI highlight talk by Dr. Anupama Hemalatha who started her group earlier this year @fmiscience.bsky.social ! She talks to us about her previous work on metabolism, redox imaging and cancer and the vision for her lab

Last Friday, we celebrated the scientific legacy of Patrick Matthias at his Farewell Symposium. Colleagues & friends gathered to honor his contributions to science, leadership and mentorship over the years. Thank you, Patrick, for your vision, dedication and lasting inspiration!

Huge congratulations to Sucheta Ghosh for successfully defending her PhD this week! Her work on dynamic profiling of the Aggresome Processing Pathway is helping us better understand how cells clean up their protein "junk" 🎓

Thank you to everyone who joined our inaugural Bridges Over Basel event yesterday! Our panel of Novartis experts shared valuable insights on moving from academia to industry, followed by great conversations over apéro 🚀

We're seeking a Research Associate in stem cell biology to join a global, interdisciplinary team investigating organoids and tissue organization. This unique role is part of a collaboration between the @priscaliberali.bsky.social lab & the @alleninstitute.org. Apply at: www.fmi.ch/education-ca...

🚨We're hiring! Join a global team at the @priscaliberali.bsky.social lab & the @alleninstitute.org to build cutting-edge image analysis workflows for complex biological datasets, including light-sheet microscopy images. Apply at: www.fmi.ch/education-ca...

Are you looking to boost the impact of your #EUfunded research project?

Join an online info session for a global overview of the free-of-charge "Booster" service.

Date and time: 18th of June 2025 at 11:00 - 12:00 CEST

👉 buff.ly/YPpkQgw

Changes to the 2026 and 2027 Work Programmes With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...

Planning to apply for #research #funding from the ERC?

From the next application rounds, expect changes to the:

• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)

More 👇 europa.eu/!RPHWvv