Exciting Instruments

Join Tim Craggs, Paul Wheeler & the single-molecule community at The Francis Crick Institute, London - this Monday! ⚡ Dive into the latest single-molecule research, techniques & discoveries. Free to attend - reserve your spot: www.eventbrite.co.uk/e/single-mol...
#biophysics #molecularbiology

Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study - Nature Methods A multi-laboratory study finds that single-molecule FRET is a reproducible and reliable approach for determining accurate distances in dye-labeled DNA duplexes.

Can smFRET deliver reproducible, absolute distance measurements?
Yes! Check out Hellenkamp et al.'s (2018) paper to learn more > www.nature.com/articles/s41...

#singlemolecule #smfret #biophyics #biochemistry

🚀 Since spinning out in 2021, our journey has been an Exciting one! Thrilled to see our CEO & founder @timcraggs.bsky.social named Entrepreneur of the Month by Insider Magazine. Read Tim’s comment below and the article here 👉 flickread.com/edition/html...

#entrepreneur #singlemolecule #sheffield

🚀 Our 'professor in a box', a quick-watch smFRET explainer video, a very exciting Chair appointment and more... see what we've been up to in September in the latest edition of our newsletter - buff.ly/EDA6U5s

#structuralbiology #moleculardynamics #singlemolecule #smfret #fcs #deeptech #startups

“Absolutely gorgeous!" That's how Edwin Antony describes the data from our EI-FLEX in his Exciting Seminar, where he discusses how DNA context regulates the myriad roles of RPA. Watch the seminar in full to learn more: youtu.be/r0yowVKdXUI

#DNA #singlemolecule #molecularbiology #structuralbiology

🚀 Here comes the next big step in our Exciting journey! Thrilled to announce the appointment of Jonathan Rigby as the Chairman of our Board. Find out more about what it means for Exciting Instruments in the press release below.
#innovation #startups #biophysics #Sheffield #pressrelease

Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET Abstract. The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has resulted in significant global mortality, with over 7 million cases reported. Despite

🤔 How did Groves et al. use the FLEX to reveal insights about SARS-CoV-2’s RNA polymerase? Find out here > doi.org/10.1093/nar/...

Want to know more about the FLEX? Learn more, request a tech spec or book a demo on our website: excitinginstruments.com/ei-flex/?utm... #smfret #RNA #nucleicacids

👋 At the Midlands Biophysics Network meeting today? So are we!

Visit our stand to chat about how we're bringing solution-based single-molecule techniques right to your benchtop - no extensive training required.

#midlandsbiophysicsnetworkmeeting #biophysics #singlemolecule #smfret #fcs

Thrilled to see long-time #FRET experts moving into single-molecule work with our technology at McMaster University! Plus, our instrument now also supports University at Albany's core facility with #smFRET & #FCS! A very Exciting week! 🙌 #biophysics #singlemolecule #structuralbiology

Tim and Paul are ready and waiting at the Biology and Physics of Prokaryotic Chromosomes conference to show you how in-solution, single-molecule fluorescence spectroscopy can help visualise structural dynamics of prokaryotic protein/DNA interactions. Visit our stand for a chat! #prokaryoticproteins

Missing biomolecular dynamics at picomolar levels? The EI-FLEX makes single-molecule research quick and easy with precision and stability. Watch Dr. Quinn below and book a demo: excitinginstruments.com/contact-us/?...
#singlemolecule #structuralbiology #moleculardynamics #smFRET #FCS

Heading to the Austrian Cryo-EM Symposium in November? Let's catch up! We'll be on hand to share how freely diffusing smFRET can complement this already exquisitely detailed technique #cryoEM #smfret #singlemolecule

Discover how single-molecule fluorescence reveals transient DNA–protein interactions, kinetics and conformational changes, and more. Meet @timcraggs.bsky.social & Paul Wheeler at next week’s events - email info@excitinginstruments.com
to schedule! #biophysics #smfret #fcs

YouTube video by Exciting Instruments What is single-molecule FRET?

What is single-molecule FRET? Watch
@timcraggs.bsky.social
explain how this technique measures nanometer-scale distances and captures single-molecule conformations - youtu.be/BpCsTVJkQyE #structuralbiology #moleculardynamics #discovery #smFRET

Substrate conformational dynamics facilitate structure-specific recognition of gapped DNA by DNA polymerase Abstract. DNA-binding proteins utilise different recognition mechanisms to locate their DNA targets; some proteins recognise specific DNA sequences, while

X-ray crystallography gives static molecular snapshots with atomic precision. Freely diffusing smFRET adds dynamics, revealing alternative states, transition rates, and validating models. See how Craggs et al. (2019) used it to reveal hidden structures: bit.ly/45Vznoh
#smfret #structuralbiology

💡 Measure fleeting protein encounters with ease - no dark rooms, bulky equipment, or extensive training. Our compact instrument delivers fast, publication-ready results from the bench in ambient light. 👉 bit.ly/4683zLQ #smFRET #FCS #biophysics #science

🚀 Hear ALEX and smFRET pioneer Shimon Weiss talk on origins, breakthroughs, and the future 👀 Watch the Exciting Seminar in full > youtu.be/MBI82_QKAnk
#smFRET #ALEX #biophysics #structuralbiology #moleculardynamics

⚡Discovery moves faster when your software keeps up. The EI-FLEX lets you visualise data in real time, validate assays with ease & share results. Publication-ready plots + full metadata for confidence in every experiment. Book a demo 👉 bit.ly/3JzwYXE #smFRET #FCS #structuralbiology #singlemolecule

Want the latest single-molecule spectroscopy news and research, groundbreaking smFRET and FCS applications, exciting updates about our products and team, and more straight into your inbox?🚀 Subscribe > fwfh6.share-eu1.hsforms.com/2tB-S9AikSdG... #singlemolecule #smfret #fcs #biophysics

Single-molecule measurements in solution expose heterogeneity, rare events, and real-time dynamics without immobilisation, yielding precise kinetic and mechanistic insights. Learn more: excitinginstruments.com?utm_source=b... #proteindynamics #DNAproteininteractions #structuralbiology #biophysics

Curious how FCS applies to stem cells, CRISPR/Cas9 models & isolated receptors at physiologically relevant protein levels? Watch Joelle Goulding’s Exciting Seminar on FCS in biological systems 👀 youtu.be/YzFw-TLG1Bk?... #fcs #biophysics

💡Heading to #MAF2025? Check out @dr-mahmoud.bsky.social presenting at the FRET Satellite workshop, or visit him and @robertbell.bsky.social at stand 14 to see EI-FLEX single-molecule and FCS data in action! Not in Montréal? Book a demo anytime 👉 excitinginstruments.com

#singlemolecule #fluorescence

🔬 Running smFRET with TIRF or just getting started? Traditional barriers holding you back?

👉 See how EI-FLEX is redefining smFRET. Watch the video + book a demo: bit.ly/474aeZA

#smFRET #TIRF #singlemolecule #biophysics #molecularbiology

🙌 Excited to share that our CEO @timcraggs.bsky.social has been elected to @biophysicalsoc.bsky.social alongside Robert Best, Tanja Mittag & Kandice Levental. Congrats also to Enrique M. De La Cruz, elected President-elect!

#biophysics #lifescience #biophysicalsociety

See biomolecules in action at the single-molecule level without the complexity. Meet us at #MAF2025 in Montréal (23–27 Aug) for demos of our compact, powerful smFRET instrument. Book a chat: meetings-eu1.hubspot.com/robert-bell1

YouTube video by Exciting Instruments Probing Functional Mechanisms of Complex Problems | Prof. Elizabeth Rhoades | Exciting Seminars

💡 Find out how Professor Rhoades used FCS to investigate the cellular internalisation of disordered proteins linked to neurodegeneration in this episode of our Exciting Seminars!

#fcs #biophysics #neurodegeneration #fluorescencecorrelationspectroscopy #singlemolecules

youtu.be/Z7nbpW1xBpg?...

Single-molecule data reveals tiny fluctuations, rare events, and fleeting states that ensemble averages often overlook. Bring this precision to your lab. Learn more: bit.ly/4makHar #molecularbiology #structuralbiology

🚀 We're on a mission to make single-molecule fluorescence spectroscopy simple and accessible - no specialist facilities, darkrooms, or complex training needed👇 Subscribe to our newsletter for updates: www.linkedin.com/build-relati... #biophysics #singlemolecules #moleculardynamics #structuralbiology

Move beyond averages. smFRET and FCS reveal real-time, single-molecule dynamics - conformational changes, binding, diffusion - missed by bulk methods. Discover more in the 2024 NAR paper on RPA-DNA interactions: academic.oup.com/nar/article/...?

#biophysics #moleculardynamics #singlemolecules

🤔 What if we could detect disease from a single molecule before symptoms even appear? This isn’t just innovation. It’s a shift in how we understand, detect, and prevent illness. Molecular insights are unlocking a new era in human health. #innovation #lifescience #biophysics