Exciting Instruments

At the final day of the @novalix.bsky.social conference? If you haven't had chance to meet with Audrey and Jake yet, there's still time to discuss how confocal fluorescence spectroscopy can accelerate your induced-proximity drug screening ⚡
#ternarycomplex #molecularglues #PROTACs #novalix

🚀 Big news from @timcraggs.bsky.social x #BPS2026: meet the new EI-FLEX Pro! Automated alignment + focus, real-time analysis with publication-ready plots, modular upgrade to 96/384 wells, no darkroom or optical table, compact benchtop. Meet us at booth 401 or get in touch for a demo! #singlemolecule

What better way to start your day than by exploring the key components of a confocal FRET experiment that ensure single-molecule sensitivity and accurate determination of FRET efficiencies? > buff.ly/NMausGH #singlemolecule #FRET #molecularbiophyics #biochemistry #molecules

Heading to #SLAS2026 today? Make sure you catch our East Coast BDM, Jake Isaacs, on the Topical Interest Group #ProximityAssays panel discussion "From #Degraders to PPI Modulators: The Expanding Universe of Proximity Medicines" at 1pm in room 204AB 💡

🇺🇸 Heading to #Novalix? Learn how confocal fluorescence spectroscopy accelerates induced-proximity drug screening. Meet our US team, Audrey & Jake, to discuss #biophysicalscreening, #molecularglues and #PROTACs, #single-molecule #proteindynamics, and more. Look out for their booth and poster!

Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo Kinesin-1 is an essential anterograde microtubule motor protein. The core kinesin motor is a homodimer of two heavy chains; N-terminal motor domains hydrolyse ATP and walk along microtubules, whilst a...

Congratulations to Alison Twelvetrees, Evelyn Smith and team at the University of Sheffield on their publication in iScience! - www.cell.com/iscience/ful...

Amazing to see the in-cell labelling and smFRET measurements in cell lysate.

#smfret #celllysate #singlemolecule #proteins

☕ Grab a cup of coffee and take 5 minutes to read the latest edition of our newsletter > 26707290.hs-sites-eu1.com/-temporary-s...

Subscribe to never miss a future edition > share-eu1.hsforms.com/2tB-S9AikSdG...

#biophysics #biochemistry #singlemolecule

Measure nanoscale distances with smFRET | Exciting Instruments Using a model DNA duplex, we demonstrate how nanoscale distances can be captured on the EI-FLEX system using single-molecule FRET.

🧐 Curious how #single-moleculeFRET measures nanoscale distances with Å precision? Our #appnote note shows smFRET on the EI-FLEX using #DNA standards, ALEX for clean FRET/stoichiometry, and Förster radii to calculate inter-dye distances > excitinginstruments.com/resource-lib...

👀 Looking for #mechanisticinsight beyond traditional biochemistry? Our EI-FLEX system reveals in-solution dynamics, kinetics & rare events with intuitive software that delivers publication-ready plots and clear interpretation in minutes. No biophysics expertise needed 💪> buff.ly/FTlfZgO

Want to add fast, solution-based #single-molecule dynamics to your workflow? Our new, practical handbook shows how confocal #smFRET reveals conformational change, heterogeneity & nanoscale distances, with clear, step-by-step guidance from basics to advanced analysis > buff.ly/xHefIrP

📢 Structural biochemists: do you have beautiful, atomic-resolution static structures, but feel like a piece of the puzzle is missing? Add single-molecule dynamics with smFRET to reveal hidden conformational changes 👉 excitinginstruments.com/resource-lib...

#structuralbiology #proteindynamics

🇺🇸 Are you in #SanFrancisco this week for #JPM26, or local to the area, and curious to learn more about the power of high-throughput single-molecule characterisation?

Drop @timcraggs.bsky.social or @robertbell.bsky.social a DM if you'd like to meet up to learn more!

Special thanks also to the
@ei-science.bsky.social team for equipping us with #fcs capabilities in @ybri-uoy.bsky.social & @york.ac.uk thanks to support from EPSRC!
@uoyopenres.bsky.social

Biology happens when molecules interact - in solution, in motion, in fleeting moments. Freely diffusing smFRET captures these dynamics with nanometre precision. Our new practical #smFRET handbook distils principles & analysis for confident, in-solution data. 📘 buff.ly/AgGQCLY #singlemolecule

Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation Abstract. Single-stranded DNA (ssDNA) intermediates which emerge during DNA metabolic processes are shielded by replication protein A (RPA). RPA binds to s

Complementing your single-molecule immobilised assays with in-solution measurements can offer physiological relevance, fewer artefacts, seamless workflows, and richer dynamics. See how Chadda et al. used in-solution methods on the EI-FLEX to resolve conflicting FRET models 👇 buff.ly/LXkkNNy

🇺🇸 We're in beautiful #SanFrancisco next week (Mon-Thurs) to meet with investors and customers. If you're in the area, we’d love to connect to discuss the power of in-solution #single-molecule techniques and our Exciting plans for 2026. Email info@excitinginstruments.com to let us know.

🚀 The future of #biotherapeutic screening is here: same-day, benchtop discovery with single-molecule sensitivity. LLNL’s preprint shows how CFPS + FCS on the EI-FLEX collapses expression → binding into 1 day. Faster than SPR’s 2–7 days. Learn more - buff.ly/70yAkZF #spr #fcs #cfps

🔎 Cryo-EM reveals stunning structures and partners perfectly with dynamic single-molecule methods to link structure to motion, uncover rare states, validate flexible regions, and map conformational changes. Get in touch to learn more - buff.ly/ncBOTrM #biochemistry #structuralbiology

🙌 What - an - Exciting - year! Thank you to everyone who has supported us throughout 2025 - it has enabled us to dream big, turn those dreams into action, bring our mission to life, and ultimately achieve all of the Exciting progress we've made. 🥂🎄🌟 Have a wonderful festive break. Here's to 2026!

Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation Abstract. Single-stranded DNA (ssDNA) intermediates which emerge during DNA metabolic processes are shielded by replication protein A (RPA). RPA binds to s

Curious how single-molecule tools are transforming our understanding of DNA? Chadda et al. used smFRET and DEER to reveal that RPA partially wraps single-stranded DNA instead of simply stretching it - academic.oup.com/nar/article/...
#DNA #smFRET #molecularbiology #proteinDNAinteractions

smFRET tracks one molecule at a time to reveal real low/high-FRET populations, dynamic transitions, and nanoscale changes that traditional FRET masks. Learn more - bit.ly/44TVTwy #smFRET #biophysics #singlemolecule

⏰ What if your experimental workflow went from weeks to minutes? @shenk0128.bsky.social shares how solution-based measurements complement TIRF:

✓ Faster results
✓ Fewer artefacts
✓ No tethering needed
✓ Proteins stay in their native, comfortable state

#singlemolecule #TIRF #proteinstructure

In this month's newsletter: a big RNA breakthrough, the power of combining structural data with dynamics, getting super fast answers to your biological questions, and some fantastic PhD opportunities. Register - fwfh6.share-eu1.hsforms.com/2tB-S9AikSdG... #rna #structuralbiology #singlemolecule

👋 Calling all Prague-based structural biologists and single-molecule enthusiasts! You are invited to listen and learn from @timcraggs.bsky.social on 9 Dec at the J. Heyrovský Institute of Physical Chemistry - www.jh-inst.cas.cz/seminar/tim-... #singlemolecule #structuralbiology #smfret #fcs

A DNA Scaffold Approach Facilitates 5′ Labeling of the SARS‐CoV‐2 RNA Pseudoknot for Single‐Molecule Förster Resonance Energy Transfer Investigation DNA scaffold-based labeling strategy is introduced that enables single-molecule Förster resonance energy transfer (smFRET) studies of the SARS-CoV-2 frameshifting pseudoknot. The smFRET measurements ...

Curious about new routes for labelling often complicated RNAs for single-molecule FRET studies? You'll want to check out Graham et al.'s recently published work in ChemPhysChem (congratulations 🥳) - buff.ly/SkaruHO
#rna #rnaresearch #virology #singlemolecule #smfret #nucleicacids

YouTube video by Exciting Instruments Mapping the global conformation of the Rag GTPase heterodimer with smFRET | Exciting Seminars

🔎 How does in-solution smFRET reveal the dynamic structure–function links in complex proteins?
Watch Prof. @shenk0128.bsky.social's seminar using the EI-FLEX to probe Rag GTPase conformations. Q&A covers labelling, HMMs & why solution-based smFRET matters.
youtu.be/2AfskEVyRCI #smfret #biophysics

Two hours to go! Join @shenk0128.bsky.social and @timcraggs.bsky.social as they dive into Rag GTPase regulation, #proteindynamics, and cutting-edge #singlemolecule science. Can’t make it live? Register to get the recording - us06web.zoom.us/meeting/regi...
#biophysics #lifescience #biophysics

🚨 Happening this Thursday! @timcraggs.bsky.social and @shenk0128.bsky.social discussing:

→ cutting-edge single-molecule science
→ insights into the mechanism and regulation of the Rag GTPase heterodimer

Register here: buff.ly/GcdLpHI #seminar #proteins #singlemolecule #biophysics #biochemistry

Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET Abstract. The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has resulted in significant global mortality, with over 7 million cases reported. Despite

Professor Robb says: "Our EI-FLEX platform has been central to understanding the molecular details of viral replication and drug action. It’s quickly become a core instrument across many aspects of our virology research." Read her paper here - doi.org/10.1093/nar/... #smFRET #drugdevelopment

⚡ What do you get when you combine a meaningful mission, innovative solutions, and an epic group of people? Something extremely Exciting 😉 We're looking for brilliant people to fill these roles & more > excitinginstruments.com/careers/

#lifesciencejobs #startupjobs #sheffieldjobs #hiring #scaleup